Ultrasensitive point-of-care biochemical sensor based on metal-AIEgen frameworks

Zhang，Jiangjiang1; Li，Ying2; Chai，Fengli1; Li，Qizhen1; Wang，Dou1; Liu，Liping1; Tang，Ben Zhong2,3; Jiang，Xingyu1

2022-07-29

10.1126/sciadv.abo1874

Science Advances   Impact Factor & Quartile

2375-2548

2375-2548

Point-of-care (POC) biochemical sensors have found broad applications in areas ranging from clinical diagnosis to environmental monitoring. However, POC sensors often suffer from poor sensitivity. Here, we synthesized a metal-organic framework, where the ligand is the aggregation-induced emission luminogen (AIEgen), which we call metal-AIEgen frameworks (MAFs), for use in the ultrasensitive POC biochemical sensors. MAFs process a unique luminescent mechanism of structural rigidity-enhanced emission to achieve a high quantum yield (~99.9%). We optimized the MAFs to show 10- to 10-fold enhanced sensitivity for a hydrogel-based POC digital sensor and lateral flow immunoassays (LFIA). MAFs have a high affinity to directly absorb proteins, which can label antibodies for immunoassays. MAFs-based LFIA with enhanced sensitivity shows robust serum detection for POC clinical diagnosis.

SCI ; EI

English

NI Journal Papers

First ; Corresponding

Chinese Academy of Sciences[QYZDJ-SSW-SLH039];

Science & Technology - Other Topics

Multidisciplinary Sciences

WOS:000836554300022

AMER ASSOC ADVANCEMENT SCIENCE

20223112526912

Antibodies ; Metal-Organic Frameworks

Medicine and Pharmacology:461.6 ; Immunology:461.9.1 ; Metallurgy:531.1 ; Organic Compounds:804.1

2-s2.0-85135221489

Scopus

1.Guangdong Provincial Key Laboratory of Advanced Biomaterials,Shenzhen Key Laboratory of Smart Healthcare Engineering,Department of Biomedical Engineering,Department of Hepatobiliary and Pancreas Surgery (The First Affiliated Hospital),Southern University of Science and Technology,Shenzhen,No. 1088 Xueyuan Rd., Nanshan District, Guangdong,518055,China
2.Center for AIE Research,College of Materials Science and Engineering,Shenzhen University,Shenzhen,Guangdong,518060,China
3.Shenzhen Institute of Aggregate Science and Technology,School of Science and Engineering,Chinese University of HongKong,Shenzhen,Guangdong,China

Zhang，Jiangjiang,Li，Ying,Chai，Fengli,et al. Ultrasensitive point-of-care biochemical sensor based on metal-AIEgen frameworks[J]. Science Advances,2022,8(30).

Zhang，Jiangjiang.,Li，Ying.,Chai，Fengli.,Li，Qizhen.,Wang，Dou.,...&Jiang，Xingyu.(2022).Ultrasensitive point-of-care biochemical sensor based on metal-AIEgen frameworks.Science Advances,8(30).

Zhang，Jiangjiang,et al."Ultrasensitive point-of-care biochemical sensor based on metal-AIEgen frameworks".Science Advances 8.30(2022).