Oxytocin and serotonin in the modulation of neural function: Neurobiological underpinnings of autism-related behavior

Zhao, Feng1,2,3,4; Zhang, Hao1,2,3,4; Wang, Peng5; Cui, Wenjie6; Xu, Kaiyong1,4; Chen, Dan1,4; Hu, Minghui1,3,4; Li, Zifa1,2,3,4; Geng, Xiwen1,2,3,4; Wei, Sheng1,2,3,4

2022-07-22

10.3389/fnins.2022.919890

FRONTIERS IN NEUROSCIENCE   Impact Factor & Quartile

1662-453X

Autism spectrum disorders (ASD) is a group of generalized neurodevelopmental disorders. Its main clinical features are social communication disorder and repetitive stereotyped behavioral interest. The abnormal structure and function of brain network is the basis of social dysfunction and stereotyped performance in patients with autism spectrum disorder. The number of patients diagnosed with ASD has increased year by year, but there is a lack of effective intervention and treatment. Oxytocin has been revealed to effectively improve social cognitive function and significantly improve the social information processing ability, empathy ability and social communication ability of ASD patients. The change of serotonin level also been reported affecting the development of brain and causes ASD-like behavioral abnormalities, such as anxiety, depression like behavior, stereotyped behavior. Present review will focus on the research progress of serotonin and oxytocin in the pathogenesis, brain circuit changes and treatment of autism. Revealing the regulatory effect and neural mechanism of serotonin and oxytocin on patients with ASD is not only conducive to a deeper comprehension of the pathogenesis of ASD, but also has vital clinical significance.

autism neural mechanisms neural circuitry oxytocin serotonin

SCI

English

Non-SUSTech

National Natural Science Foundation of China["81974553","82004078"] ; Natural Science Foundation of Shandong Province["ZR2020ZD17","ZR2021LZY018"] ; Chinese Medicine and Brain Science Youth Scientific Research Innovation Team, Shandong University of Traditional Chinese Medicine[22202101] ; Shandong Medical and Health Science and Technology Development Program[202102050496]

Neurosciences & Neurology

Neurosciences

WOS:000837225600001

FRONTIERS MEDIA SA

Web of Science

1.Shandong Univ Tradit Chinese Med, Expt Ctr, Jinan, Peoples R China
2.Shandong Univ Tradit Chinese Med, Key Lab Tradit Chinese Med Class Theory, Minist Educ, Jinan, Peoples R China
3.TAIYUE Postdoctoral Innovat & Practice Base, Jinan, Peoples R China
4.Shandong Univ Tradit Chinese Med, Chinese Med & Brain Sci Core Facil, Jinan, Peoples R China
5.Shanghai Jiao Tong Univ, Sch Environm Sci & Engn, Shanghai, Peoples R China
6.Southern Univ Sci & Technol, Dept Biol, Shenzhen, Peoples R China

Zhao, Feng,Zhang, Hao,Wang, Peng,et al. Oxytocin and serotonin in the modulation of neural function: Neurobiological underpinnings of autism-related behavior[J]. FRONTIERS IN NEUROSCIENCE,2022,16.

Zhao, Feng.,Zhang, Hao.,Wang, Peng.,Cui, Wenjie.,Xu, Kaiyong.,...&Wei, Sheng.(2022).Oxytocin and serotonin in the modulation of neural function: Neurobiological underpinnings of autism-related behavior.FRONTIERS IN NEUROSCIENCE,16.

Zhao, Feng,et al."Oxytocin and serotonin in the modulation of neural function: Neurobiological underpinnings of autism-related behavior".FRONTIERS IN NEUROSCIENCE 16(2022).