| Title | Organocatalytic Asymmetric 3-Allenylation of Indoles via Remote Stereocontrolled 1,10-Additions of Alkynyl Indole Imine Methides |
| Author | |
| Corresponding Author | Li, Pengfei; Li, Wenjun |
| Publication Years | 2022-08-01
|
| DOI | |
| Source Title | |
| ISSN | 2193-5807
|
| EISSN | 2193-5815
|
| Abstract | A chiral phosphoric acids catalyzed regio- and enantioselective 1,10-conjugate addition of 2-arylindoles to alkynyl indole imine methides formed in situ from alpha-(6-indolyl)propargylic alcohols has been developed. With the established system, organocatalytic asymmetric 3-allenylation of indoles was realized, affording a broad scope of axially chiral tetrasubstituted allenes bearing two indole motifs in high yields with stereoselectivities. Importantly, the organocatalytic remote stereocontrolled strategy disclosed the asymmetric 3-allenylation of indoles via 1,10-conjugate addition for the first time. |
| Keywords | |
| URL | [Source Record] |
| Indexed By | |
| Language | English
|
| SUSTech Authorship | Corresponding
|
| Funding Project | Natural Science Foundation of Shandong Province[ZR2021MB026]
; Special Funds of the Taishan Scholar Program of Shandong Province[tsqn201812047]
; Shenzhen Innovation of Science and Technology Commission[20200925151614002]
; Guangdong Innovative Program[2019BT02Y335]
; Guangdong Provincial Key Laboratory of Catalysis[2020B121201002]
|
| WOS Research Area | Chemistry
|
| WOS Subject | Chemistry, Organic
|
| WOS Accession No | WOS:000837474900001
|
| Publisher | |
| Data Source | Web of Science
|
| Citation statistics |
Cited Times [WOS]:2
|
| Document Type | Journal Article |
| Identifier | http://kc.sustech.edu.cn/handle/2SGJ60CL/382296 |
| Department | Shenzhen Grubbs Institute |
| Affiliation | 1.Qingdao Univ, Sch Pharm, Dept Med Chem, Qingdao 266021, Shandong, Peoples R China 2.Southern Univ Sci & Technol, Coll Sci, Shenzhen Grubbs Inst, Shenzhen 518055, Peoples R China 3.Southern Univ Sci & Technol, Coll Sci, Guangdong Prov Key Lab Catalysis, Shenzhen 518055, Peoples R China |
| Corresponding Author Affilication | Shenzhen Grubbs Institute; Southern University of Science and Technology |
| Recommended Citation GB/T 7714 |
Wang, Ziyang,Cheng, Yuyu,Yue, Zhibin,et al. Organocatalytic Asymmetric 3-Allenylation of Indoles via Remote Stereocontrolled 1,10-Additions of Alkynyl Indole Imine Methides[J]. Asian Journal of Organic Chemistry,2022.
|
| APA |
Wang, Ziyang,Cheng, Yuyu,Yue, Zhibin,Chen, Xuling,Li, Pengfei,&Li, Wenjun.(2022).Organocatalytic Asymmetric 3-Allenylation of Indoles via Remote Stereocontrolled 1,10-Additions of Alkynyl Indole Imine Methides.Asian Journal of Organic Chemistry.
|
| MLA |
Wang, Ziyang,et al."Organocatalytic Asymmetric 3-Allenylation of Indoles via Remote Stereocontrolled 1,10-Additions of Alkynyl Indole Imine Methides".Asian Journal of Organic Chemistry (2022).
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