| Title | The SWI/SNF chromatin remodeling factor DPF3 regulates metastasis of ccRCC by modulating TGF-β signaling |
| Author | |
| Corresponding Author | Cui，Huanhuan; Chen，Wei |
| Publication Years | 2022-08-09
|
| DOI | |
| Source Title | |
| EISSN | 2041-1723
|
| Volume | 13Issue:1Pages:4680 |
| Abstract | DPF3, a component of the SWI/SNF chromatin remodeling complex, has been associated with clear cell renal cell carcinoma (ccRCC) in a genome-wide association study. However, the functional role of DPF3 in ccRCC development and progression remains unknown. In this study, we demonstrate that DPF3a, the short isoform of DPF3, promotes kidney cancer cell migration both in vitro and in vivo, consistent with the clinical observation that DPF3a is significantly upregulated in ccRCC patients with metastases. Mechanistically, DPF3a specifically interacts with SNIP1, via which it forms a complex with SMAD4 and p300 histone acetyltransferase (HAT), the major transcriptional regulators of TGF-β signaling pathway. Moreover, the binding of DPF3a releases the repressive effect of SNIP1 on p300 HAT activity, leading to the increase in local histone acetylation and the activation of cell movement related genes. Overall, our findings reveal a metastasis-promoting function of DPF3, and further establish the link between SWI/SNF components and ccRCC. |
| URL | [Source Record] |
| Indexed By | |
| Language | English
|
| Important Publications | NI Journal Papers
|
| SUSTech Authorship | First
; Corresponding
|
| Funding Project | National Outstanding Youth Science Fund Project of National Natural Science Foundation of China[31900462]
|
| WOS Research Area | Science & Technology - Other Topics
|
| WOS Subject | Multidisciplinary Sciences
|
| WOS Accession No | WOS:000842289800027
|
| Publisher | |
| Scopus EID | 2-s2.0-85135731584
|
| Data Source | Scopus
|
| Citation statistics |
Cited Times [WOS]:4
|
| Document Type | Journal Article |
| Identifier | http://kc.sustech.edu.cn/handle/2SGJ60CL/382320 |
| Department | School of Life Sciences 前沿与交叉科学研究院 理学院_化学系 生命科学学院_生物系 南方科技大学医学院_药理学系 |
| Affiliation | 1.Shenzhen Key Laboratory of Gene Regulation and Systems Biology,School of Life Sciences,Southern University of Science and Technology,Shenzhen,518005,China 2.Department of Biology,School of Life Sciences,Southern University of Science and Technology,Shenzhen,518005,China 3.Academy for Advanced Interdisciplinary Studies,Southern University of Science and Technology,Shenzhen,518005,China 4.Key Laboratory of Molecular Design for Plant Cell Factory of Guangdong Higher Education Institutes,School of Life Sciences,Southern University of Science and Technology,Shenzhen,518005,China 5.Computational Bioscience Research Center,Computer,Electrical and Mathematical Sciences and Engineering Division,King Abdullah University of Science and Technology (KAUST),Thuwal,23955-6900,Saudi Arabia 6.Department of Chemistry,School of Science,Southern University of Science and Technology,Shenzhen,518005,China 7.Cardiovascular Genetics,Charité-Universitätsmedizin Berlin,Berlin,13125,Germany 8.Shenzhen Key Laboratory of Gene Regulation and Systems Biology,School of Life Sciences,Southern University of Science and Technology,Shenzhen,518005,China 9.Department of Biology,School of Life Sciences,Southern University of Science and Technology,Shenzhen,518005,China 10.Academy for Advanced Interdisciplinary Studies,Southern University of Science and Technology,Shenzhen,518005,China 11.Key Laboratory of Molecular Design for Plant Cell Factory of Guangdong Higher Education Institutes,School of Life Sciences,Southern University of Science and Technology,Shenzhen,518005,China 12.Computational Bioscience Research Center,Computer,Electrical and Mathematical Sciences and Engineering Division,King Abdullah University of Science and Technology (KAUST),Thuwal,23955-6900,Saudi Arabia 13.Department of Chemistry,School of Science,Southern University of Science and Technology,Shenzhen,518005,China 14.Cardiovascular Genetics,Charité-Universitätsmedizin Berlin,Berlin,13125,Germany |
| First Author Affilication | School of Life Sciences; Department of Biology; Academy for Advanced Interdisciplinary Studies |
| Corresponding Author Affilication | School of Life Sciences; Department of Biology; Academy for Advanced Interdisciplinary Studies |
| First Author's First Affilication | School of Life Sciences |
| Recommended Citation GB/T 7714 |
Cui，Huanhuan,Yi，Hongyang,Bao，Hongyu,et al. The SWI/SNF chromatin remodeling factor DPF3 regulates metastasis of ccRCC by modulating TGF-β signaling[J]. Nature Communications,2022,13(1):4680.
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| APA |
Cui，Huanhuan.,Yi，Hongyang.,Bao，Hongyu.,Tan，Ying.,Tian，Chi.,...&Chen，Wei.(2022).The SWI/SNF chromatin remodeling factor DPF3 regulates metastasis of ccRCC by modulating TGF-β signaling.Nature Communications,13(1),4680.
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| MLA |
Cui，Huanhuan,et al."The SWI/SNF chromatin remodeling factor DPF3 regulates metastasis of ccRCC by modulating TGF-β signaling".Nature Communications 13.1(2022):4680.
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