中文版 | English
Title

Vaginal microbiota and personal risk factors associated with HPV status conversion-A new approach to reduce the risk of cervical cancer?

Author
Publication Years
2022
DOI
Source Title
ISSN
1932-6203
EISSN
1932-6203
Volume17Issue:8
Abstract

Vaginal microbiota (VMB) is associated with changes in Human papilloma virus (HPV) status, which consequently influences the risk of cervical cancer. This association was often confounded by personal risk factors. This pilot research aimed to explore the relationship between vaginal microbiota, personal risk factors and their interactions with HPV status conversion to identify the vaginal microbiota that was associated with HPV clearance under heterogeneous personal risk factors. A total of 38 women participated by self-collecting a cervicovaginal mucus (CVM) sample that was sent for metagenomics sequencing. Most of the participants also filled in personal risk factors questionnaire through an eHealth platform and authorized the use of their previous HPV genotyping results stored in this eHealth platform. Based on the two HPV results, the participants were grouped into three cohorts, namely HPV negative, HPV persistent infection, and HPV status conversion. The relative abundance of VMB and personal factors were compared among these three cohorts. A correlation investigation was performed between VMB and the significant personal factors to characterize a robustness of the panel for HPV status change using R programming. At baseline, 12 participants were HPV-negative, and 22 were HPV-positive. Within one year, 18 women remained HPV-positive, 12 were HPV-negative and 4 participants showed HPV clearance. The factors in the eHealth questionnaire were systematically evaluated which identified several factors significantly associated with persistent HPV infection, including age, salary, history of reproductive tract infection, and the total number of sexual partners. Concurrent vaginal microbiome samples suggest that a candidate biomarker panel consisting of Lactobacillus gasseri, Streptococcus agalactiae, and Timona prevotella bacteria, which may be associated with HPV clearance. This pilot study indicates a stable HPV status-related vaginal microbe environment. To establish a robust biomarker panel for clinical use, larger cohorts will be recruited into follow-up studies.

URL[Source Record]
Indexed By
Language
English
SUSTech Authorship
Others
Funding Project
Shenzhen Innovation Committee of Science and Technology[ZDSYS20200811144002008]
WOS Research Area
Science & Technology - Other Topics
WOS Subject
Multidisciplinary Sciences
WOS Accession No
WOS:000944126000044
Publisher
Scopus EID
2-s2.0-85135768376
Data Source
Scopus
Citation statistics
Cited Times [WOS]:1
Document TypeJournal Article
Identifierhttp://kc.sustech.edu.cn/handle/2SGJ60CL/382333
DepartmentDepartment of Biology
生命科学学院
Affiliation
1.BGI Genomics,BGI-Shenzhen,Shenzhen,China
2.Department of Traditional Chinese Medicine,Women & Children Health Institute Futian Shenzhen,Shenzhen,China
3.School of Pharmaceutical Sciences,Sun Yat-sen University,Guangzhou,China
4.BGI-Shenzhen,Shenzhen Key Laboratory of Unknown Pathogen,Shenzhen,China
5.Shouguang Hospital of Traditional Chinese Medicine,Reproduction Medicine Center Shanghai,China
6.Department of Biology,Southern University of Science and Technology,Shenzhen,China
Recommended Citation
GB/T 7714
Yang,Zhongzhou,Zhang,Ye,Stubbe-Espejel,Araceli,et al. Vaginal microbiota and personal risk factors associated with HPV status conversion-A new approach to reduce the risk of cervical cancer?[J]. PloS one,2022,17(8).
APA
Yang,Zhongzhou.,Zhang,Ye.,Stubbe-Espejel,Araceli.,Zhao,Yumei.,Liu,Mengping.,...&Li,Yantao.(2022).Vaginal microbiota and personal risk factors associated with HPV status conversion-A new approach to reduce the risk of cervical cancer?.PloS one,17(8).
MLA
Yang,Zhongzhou,et al."Vaginal microbiota and personal risk factors associated with HPV status conversion-A new approach to reduce the risk of cervical cancer?".PloS one 17.8(2022).
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