中文版 | English
Title

Diversity of interneurons in the lateral and basal amygdala

Author
Corresponding AuthorSah,Pankaj
Publication Years
2020-12-01
DOI
Source Title
EISSN
2056-7936
Volume5Issue:1
Abstract
The basolateral amygdala (BLA) is a temporal lobe structure that contributes to a host of behaviors. In particular, it is a central player in learning about aversive events and thus assigning emotional valence to sensory events. It is a cortical-like structure and contains glutamatergic pyramidal neurons and GABAergic interneurons. It is divided into the lateral (LA) and basal (BA) nuclei that have distinct cell types and connections. Interneurons in the BLA are a heterogenous population, some of which have been implicated in specific functional roles. Here we use optogenetics and slice electrophysiology to investigate the innervation, postsynaptic receptor stoichiometry, and plasticity of excitatory inputs onto interneurons within the BLA. Interneurons were divided into six groups based on their discharge properties, each of which received input from the auditory thalamus (AT) and auditory cortex (AC). Auditory innervation was concentrated in the LA, and optogenetic stimulation evoked robust synaptic responses in nearly all interneurons, drove many cells to threshold, and evoked disynaptic inhibition in most interneurons. Auditory input to the BA was sparse, innervated fewer interneurons, and evoked smaller synaptic responses. Biophysically, the subunit composition and distribution of AMPAR and NMDAR also differed between the two nuclei, with fewer BA IN expressing calcium permeable AMPAR, and a higher proportion expressing GluN2B-containing NMDAR. Finally, unlike LA interneurons, LTP could not be induced in the BA. These findings show that interneurons in the LA and BA are physiologically distinct populations and suggest they may have differing roles during associative learning.
URL[Source Record]
Indexed By
Language
English
SUSTech Authorship
Corresponding
Funding Project
Australian Research Council[CE140100007];
WOS Accession No
WOS:000619090300010
Scopus EID
2-s2.0-85092791319
Data Source
Scopus
Citation statistics
Cited Times [WOS]:19
Document TypeJournal Article
Identifierhttp://kc.sustech.edu.cn/handle/2SGJ60CL/382339
DepartmentDepartment of Biology
生命科学学院
Affiliation
1.Queensland Brain Institute,University of Queensland,St Lucia,4072,Australia
2.Department of Anatomy,Yong Yoo Lin School of Medicine,National University of Singapore,Singapore,117594,Singapore
3.Brain Research Centre and Department of Biology,Southern University of Science and Technology,Shenzhen,Nanshan District,China
Corresponding Author AffilicationDepartment of Biology;  School of Life Sciences
Recommended Citation
GB/T 7714
Polepalli,Jai S.,Gooch,Helen,Sah,Pankaj. Diversity of interneurons in the lateral and basal amygdala[J]. npj Science of Learning,2020,5(1).
APA
Polepalli,Jai S.,Gooch,Helen,&Sah,Pankaj.(2020).Diversity of interneurons in the lateral and basal amygdala.npj Science of Learning,5(1).
MLA
Polepalli,Jai S.,et al."Diversity of interneurons in the lateral and basal amygdala".npj Science of Learning 5.1(2020).
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