Title | Diversity of interneurons in the lateral and basal amygdala |
Author | |
Corresponding Author | Sah,Pankaj |
Publication Years | 2020-12-01
|
DOI | |
Source Title | |
EISSN | 2056-7936
|
Volume | 5Issue:1 |
Abstract | The basolateral amygdala (BLA) is a temporal lobe structure that contributes to a host of behaviors. In particular, it is a central player in learning about aversive events and thus assigning emotional valence to sensory events. It is a cortical-like structure and contains glutamatergic pyramidal neurons and GABAergic interneurons. It is divided into the lateral (LA) and basal (BA) nuclei that have distinct cell types and connections. Interneurons in the BLA are a heterogenous population, some of which have been implicated in specific functional roles. Here we use optogenetics and slice electrophysiology to investigate the innervation, postsynaptic receptor stoichiometry, and plasticity of excitatory inputs onto interneurons within the BLA. Interneurons were divided into six groups based on their discharge properties, each of which received input from the auditory thalamus (AT) and auditory cortex (AC). Auditory innervation was concentrated in the LA, and optogenetic stimulation evoked robust synaptic responses in nearly all interneurons, drove many cells to threshold, and evoked disynaptic inhibition in most interneurons. Auditory input to the BA was sparse, innervated fewer interneurons, and evoked smaller synaptic responses. Biophysically, the subunit composition and distribution of AMPAR and NMDAR also differed between the two nuclei, with fewer BA IN expressing calcium permeable AMPAR, and a higher proportion expressing GluN2B-containing NMDAR. Finally, unlike LA interneurons, LTP could not be induced in the BA. These findings show that interneurons in the LA and BA are physiologically distinct populations and suggest they may have differing roles during associative learning. |
URL | [Source Record] |
Indexed By | |
Language | English
|
SUSTech Authorship | Corresponding
|
Funding Project | Australian Research Council[CE140100007];
|
WOS Accession No | WOS:000619090300010
|
Scopus EID | 2-s2.0-85092791319
|
Data Source | Scopus
|
Citation statistics |
Cited Times [WOS]:16
|
Document Type | Journal Article |
Identifier | http://kc.sustech.edu.cn/handle/2SGJ60CL/382339 |
Department | Department of Biology 生命科学学院 |
Affiliation | 1.Queensland Brain Institute,University of Queensland,St Lucia,4072,Australia 2.Department of Anatomy,Yong Yoo Lin School of Medicine,National University of Singapore,Singapore,117594,Singapore 3.Brain Research Centre and Department of Biology,Southern University of Science and Technology,Shenzhen,Nanshan District,China |
Corresponding Author Affilication | Department of Biology; School of Life Sciences |
Recommended Citation GB/T 7714 |
Polepalli,Jai S.,Gooch,Helen,Sah,Pankaj. Diversity of interneurons in the lateral and basal amygdala[J]. npj Science of Learning,2020,5(1).
|
APA |
Polepalli,Jai S.,Gooch,Helen,&Sah,Pankaj.(2020).Diversity of interneurons in the lateral and basal amygdala.npj Science of Learning,5(1).
|
MLA |
Polepalli,Jai S.,et al."Diversity of interneurons in the lateral and basal amygdala".npj Science of Learning 5.1(2020).
|
Files in This Item: | There are no files associated with this item. |
|
Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.
Edit Comment