Biomimetic semiconducting polymer dots for highly specific NIR-II fluorescence imaging of glioma

Men，Xiaoju1,2,3; Geng，Xiaorui2,3; Zhang，Zhe4; Chen，Haobin5; Du，Meng6; Chen，Zhiyi6; Liu，Gang7; Wu，Changfeng4; Yuan，Zhen2,3

2022-12-01

10.1016/j.mtbio.2022.100383

Materials Today Bio   Impact Factor & Quartile

2590-0064

2590-0064

Glioma with very short medium survival time consists of 80% of primary malignant types of brain tumors. The unique microenvironment such as the existence of the blood-brain barrier (BBB) makes the glioma theranostics exhibit low sensitivity in diagnosis, a poor prognosis and low treatment efficacy. Therefore, the development of multifunctional nanoplatform that can cross BBB and target the glioma is essential for the high-sensitivity detection and ablation of cancer cells. In this study, C6 cell membrane-coated conjugated polymer dots (Pdots-C6) were constructed for targeted glioma tumor detection. As a new kind of biomimetic and biocompatible nanoprobes, Pdots-C6 preserve the complex biological functions of natural cell membranes while possessing physicochemical properties for NIR-II fluorescence imaging of glioma. After encapsulating C6 cell membrane on the surface of conjugated Pdots, Pdots-C6 exhibited the most favorable specific targeting capabilities in vitro and in vivo. In particular, this pilot study demonstrates that biomimetic nanoparticles offer a potential tool to enhance specific targeting to the brain, hence improving glioma tumor detection accuracy.

Brain tumor Cell membrane coated nanoparticles Conjugated polymers Polymer dots Second near-infrared imaging

SCI ; EI

English

Others

Natural Science Foundation of Guangdong Province[EF017/FHS-YZ/2021/GDSTCRSKTO];Technology Development[FDCT 0011/2018/A1];Technology Development[FDCT 0020/2019/AMJ];Shenzhen Fundamental Research Program[JCYJ20180305125425815];Shenzhen Graduate School, Peking University[JCYJ20210324115807021];Shenzhen Graduate School, Peking University[KQTD20170810111314625];Universidade de Macau[MYRG 2020-00067-FHS];Universidade de Macau[MYRG2018-00081-FHS];Universidade de Macau[MYRG2019-00082-FHS];Shenzhen Bay Laboratory[SZBL2021080601002];

Engineering ; Materials Science

Engineering, Biomedical ; Materials Science, Biomaterials

WOS:000843486300003

ELSEVIER

20223412593031

Biocompatibility ; Biomimetics ; Brain ; Cancer cells ; Cells ; Cytology ; Diagnosis ; Fluorescence imaging ; Functional polymers ; Infrared devices ; Nanoparticles ; Physicochemical properties ; Plastic coatings ; Semiconducting polymers ; Thermography (imaging) ; Tumors

Biomedical Engineering:461.1 ; Biological Materials and Tissue Engineering:461.2 ; Medicine and Pharmacology:461.6 ; Biotechnology:461.8 ; Biology:461.9 ; Immunology:461.9.1 ; Semiconducting Materials:712.1 ; Photography:742.1 ; Imaging Techniques:746 ; Nanotechnology:761 ; Physical Chemistry:801.4 ; Coating Materials:813.2 ; Polymeric Materials:815.1 ; Organic Polymers:815.1.1 ; Polymer Applications:817.2 ; Solid State Physics:933

2-s2.0-85135919912

Scopus

1.Hunan Key Laboratory of the Research and Development of Novel Pharmaceutical Preparations,Changsha Medical University,Changsha,Academician Workstation,410219,China
2.Faculty of Health Sciences,University of Macau,Macau SAR,999078,Macao
3.Centre for Cognitive and Brain Sciences,University of Macau,Macau SAR,999078,Macao
4.Department of Biomedical Engineering,Southern University of Science and Technology,Shenzhen,Guangdong,China
5.Department of Biomedical Engineering,School of Basic Medical Sciences,Central South University,Changsha,410013,China
6.Institute of Medical Imaging,Hengyang Medical School,University of South China,Hengyang,China
7.Center for Molecular Imaging and Translational Medicine,Xiamen University,Xiamen,China

Men，Xiaoju,Geng，Xiaorui,Zhang，Zhe,et al. Biomimetic semiconducting polymer dots for highly specific NIR-II fluorescence imaging of glioma[J]. Materials Today Bio,2022,16.

Men，Xiaoju.,Geng，Xiaorui.,Zhang，Zhe.,Chen，Haobin.,Du，Meng.,...&Yuan，Zhen.(2022).Biomimetic semiconducting polymer dots for highly specific NIR-II fluorescence imaging of glioma.Materials Today Bio,16.

Men，Xiaoju,et al."Biomimetic semiconducting polymer dots for highly specific NIR-II fluorescence imaging of glioma".Materials Today Bio 16(2022).