中文版 | English
Title

Cryo-EM structure studies of the human VPS10 domain-containing receptor SorCS3

Author
Corresponding AuthorLi,Haiying; Zhai,Liting; Zhang,Xi
Publication Years
2022-10-08
DOI
Source Title
ISSN
0006-291X
EISSN
1090-2104
Volume624Pages:89-94
Abstract
The human VPS10 domain-containing receptor SorCS3 belongs to the Vps10p-domain receptor family and is an important receptor for regulating normal cellular functions via protein sorting. Here, we determined the cryo-EM structure of the full-length SorCS3 receptor and further found that there were at least three distinct conformations (monomer, M-shaped dimer and N-shaped dimer) of SorCS3 in the apo state. The differences between the two dimer conformations were caused by PKD1-2 assembly. In contrast to its homologous proteins, the conserved residues GLN198, ARG678, TYR430, GLU1020 and ASP1024 may be key points for its dimerization and for protein/polypeptide binding. These results showed the structural details of apo-SorCS3, which provides a foundation for elucidating the mechanism of protein sorting.
Keywords
URL[Source Record]
Indexed By
Language
English
SUSTech Authorship
Others
Funding Project
Medical Scientific Reuter Foundation of Guangdong Province of China[A2021333] ; Shenzhen Science and Technology Innovation Commission Project[JCYJ20190808120613189] ; Shenzhen Pea-cock Program-Project Development Fund[20190904141C]
WOS Research Area
Biochemistry & Molecular Biology ; Biophysics
WOS Subject
Biochemistry & Molecular Biology ; Biophysics
WOS Accession No
WOS:000852817200014
Publisher
ESI Research Field
BIOLOGY & BIOCHEMISTRY
Scopus EID
2-s2.0-85135813394
Data Source
Scopus
Citation statistics
Cited Times [WOS]:1
Document TypeJournal Article
Identifierhttp://kc.sustech.edu.cn/handle/2SGJ60CL/382611
DepartmentSouthern University of Science and Technology
Affiliation
1.The University of Hong Kong–Shenzhen Hospital,Shenzhen,Guangdong Province,518000,China
2.Shenzhen University General Hospital,Shenzhen,Guangdong Province,518000,China
3.Southern University of Science and Technology,Shenzhen,Guangdong Province,518055,China
4.South China Hospital of Shenzhen University,Shenzhen,Guangdong Province,518111,China
5.Stanford University,Stanford,CA 94305,United States
6.Shenzhen Institutes of Advanced Technology Chinese Academy of Sciences,Shenzhen,Guangdong Province,518055,China
7.Shenzhen People's Second Hospital,Shenzhen,Guangdong Province,518000,China
Recommended Citation
GB/T 7714
Dong,Fengquan,Wu,Cang,Jiang,Weipeng,et al. Cryo-EM structure studies of the human VPS10 domain-containing receptor SorCS3[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2022,624:89-94.
APA
Dong,Fengquan.,Wu,Cang.,Jiang,Weipeng.,Zhai,Maocai.,Li,Haiying.,...&Zhang,Xi.(2022).Cryo-EM structure studies of the human VPS10 domain-containing receptor SorCS3.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,624,89-94.
MLA
Dong,Fengquan,et al."Cryo-EM structure studies of the human VPS10 domain-containing receptor SorCS3".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 624(2022):89-94.
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