Title | Cryo-EM structure studies of the human VPS10 domain-containing receptor SorCS3 |
Author | |
Corresponding Author | Li,Haiying; Zhai,Liting; Zhang,Xi |
Publication Years | 2022-10-08
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DOI | |
Source Title | |
ISSN | 0006-291X
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EISSN | 1090-2104
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Volume | 624Pages:89-94 |
Abstract | The human VPS10 domain-containing receptor SorCS3 belongs to the Vps10p-domain receptor family and is an important receptor for regulating normal cellular functions via protein sorting. Here, we determined the cryo-EM structure of the full-length SorCS3 receptor and further found that there were at least three distinct conformations (monomer, M-shaped dimer and N-shaped dimer) of SorCS3 in the apo state. The differences between the two dimer conformations were caused by PKD1-2 assembly. In contrast to its homologous proteins, the conserved residues GLN198, ARG678, TYR430, GLU1020 and ASP1024 may be key points for its dimerization and for protein/polypeptide binding. These results showed the structural details of apo-SorCS3, which provides a foundation for elucidating the mechanism of protein sorting. |
Keywords | |
URL | [Source Record] |
Indexed By | |
Language | English
|
SUSTech Authorship | Others
|
Funding Project | Medical Scientific Reuter Foundation of Guangdong Province of China[A2021333]
; Shenzhen Science and Technology Innovation Commission Project[JCYJ20190808120613189]
; Shenzhen Pea-cock Program-Project Development Fund[20190904141C]
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WOS Research Area | Biochemistry & Molecular Biology
; Biophysics
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WOS Subject | Biochemistry & Molecular Biology
; Biophysics
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WOS Accession No | WOS:000852817200014
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Publisher | |
ESI Research Field | BIOLOGY & BIOCHEMISTRY
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Scopus EID | 2-s2.0-85135813394
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Data Source | Scopus
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Citation statistics |
Cited Times [WOS]:1
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Document Type | Journal Article |
Identifier | http://kc.sustech.edu.cn/handle/2SGJ60CL/382611 |
Department | Southern University of Science and Technology |
Affiliation | 1.The University of Hong Kong–Shenzhen Hospital,Shenzhen,Guangdong Province,518000,China 2.Shenzhen University General Hospital,Shenzhen,Guangdong Province,518000,China 3.Southern University of Science and Technology,Shenzhen,Guangdong Province,518055,China 4.South China Hospital of Shenzhen University,Shenzhen,Guangdong Province,518111,China 5.Stanford University,Stanford,CA 94305,United States 6.Shenzhen Institutes of Advanced Technology Chinese Academy of Sciences,Shenzhen,Guangdong Province,518055,China 7.Shenzhen People's Second Hospital,Shenzhen,Guangdong Province,518000,China |
Recommended Citation GB/T 7714 |
Dong,Fengquan,Wu,Cang,Jiang,Weipeng,et al. Cryo-EM structure studies of the human VPS10 domain-containing receptor SorCS3[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2022,624:89-94.
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APA |
Dong,Fengquan.,Wu,Cang.,Jiang,Weipeng.,Zhai,Maocai.,Li,Haiying.,...&Zhang,Xi.(2022).Cryo-EM structure studies of the human VPS10 domain-containing receptor SorCS3.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,624,89-94.
|
MLA |
Dong,Fengquan,et al."Cryo-EM structure studies of the human VPS10 domain-containing receptor SorCS3".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 624(2022):89-94.
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