TAB2 Promotes the Biological Functions of Head and Neck Squamous Cell Carcinoma Cells via EMT and PI3K Pathway
Background: Transforming growth factor β1-activated kinase 1 binding protein 2 (TAB2) mediates a variety of biological processes through activated nuclear factor κ-light-chain-enhancer of activated B cell (NF-κB) signaling pathways. TAB2 has been reported to be upregulated in a variety of tumors. However, little is known about its potential role in oral squamous cell carcinoma (OSCC). Material and Methods. Patients' clinicopathological and transcription data were obtained from The Cancer Genome Atlas (TCGA) database. Immunohistochemistry staining was used to determine TAB2 expression in OSCC tissues (IHC). The expression of TAB2 in OSCC cell lines was detected by western blotting. The CCK-8 test and flow cytometry assay were utilized to evaluate cell proliferation, apoptosis, and cell cycle in OSCC cell lines. Enrichment analysis and identification of predicted signaling pathways were performed by Gene Ontology and KEGG analysis. Finally, the expression of downstream signal molecules was performed using western blotting to validate the mechanism investigations. Results: TAB2 expression level was aberrantly upregulated in OSCC patients. TAB2 expression was shown to be inversely associated to prognosis. The phenotypic of OSCC cells was considerably impacted by TAB2. OSCC cells with deleted TAB2 exhibit decreased proliferation and increased apoptosis. Additionally, OSCC progression is aided by TAB2 overexpression. Further mechanism studies showed that TAB2 could regulate the progression of OSCC by mediating the upregulation of EMT and PI3K-AKT signaling pathways. Conclusion: This study sheds light on the carcinogenic role of TAB2 in OSCC and provides a potential therapeutic strategy.
National Natural Science Foundation of China ; Shenzhen Science and Technology Project[JCYJ20210324114200001]
|WOS Research Area|
Biotechnology & Applied Microbiology ; Genetics & Heredity ; Research & Experimental Medicine ; Pathology
Biotechnology & Applied Microbiology ; Genetics & Heredity ; Medicine, Research & Experimental ; Pathology
|WOS Accession No|
|ESI Research Field|
Cited Times [WOS]:0
|Document Type||Journal Article|
|Department||Shenzhen People's Hospital|
1.Department of Stomatology,Shenzhen People's Hospital (The Second Clinical Medical College,Jinan University,First Affiliated Hospital,Southern University of Science and Technology),Shenzhen,518020,China
2.Department of Stomatology,Pingshan District People's Hospital of Shenzhen,Shenzhen,518118,China
|First Author Affilication||Shenzhen People's Hospital|
|First Author's First Affilication||Shenzhen People's Hospital|
Liu，Huijuan,Zhang，Hui,Fan，Haidong,et al. TAB2 Promotes the Biological Functions of Head and Neck Squamous Cell Carcinoma Cells via EMT and PI3K Pathway[J]. DISEASE MARKERS,2022,2022.
Liu，Huijuan,Zhang，Hui,Fan，Haidong,Tang，Su,&Weng，Junquan.(2022).TAB2 Promotes the Biological Functions of Head and Neck Squamous Cell Carcinoma Cells via EMT and PI3K Pathway.DISEASE MARKERS,2022.
Liu，Huijuan,et al."TAB2 Promotes the Biological Functions of Head and Neck Squamous Cell Carcinoma Cells via EMT and PI3K Pathway".DISEASE MARKERS 2022(2022).
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