Topographical biointerface regulating cellular functions for bone tissue engineering
|Corresponding Author||Fang，Ju; Ren，Fuzeng|
The physiochemical properties of the implant interface significantly influence cell growth, differentiation, cellular matrix deposition, and mineralisation, and eventually, determine the bone regeneration efficiency. Cells directly sense and respond to the physical, chemical, and mechanical cues of the implant surface, and it is increasingly recognized that surface topography can evoke specific cellular responses, conferring biological functions on substrate materials and regulating tissue regeneration. Current progress towards the fundamental understanding of the interplay between the cell and topographical surface has been made by combined advance in fabrication technologies and cell biology. Particularly, the precise fabrication and control of nano/microscale topographies can provide the fundamental knowledge of the mechanotransduction process that governs the cellular response as well as the knowledge of how the specific features drive cells towards a defined differentiation outcome. In this review, we first introduce common techniques and substrate materials for designing and fabricating micro/nano-topographical surfaces for bone regeneration. We then illustrate the intrinsic relationship of topological cues, cellular signal transduction, and cell functions and fates in osteogenic differentiation. Finally, we discuss the challenges and the future of using topological cues as a cell therapy to direct bone tissue regeneration.
First ; Corresponding
|EI Accession Number|
Bone ; Cell proliferation ; Signal transduction ; Topography ; Topology
|ESI Classification Code|
Biomedical Engineering:461.1 ; Biological Materials and Tissue Engineering:461.2 ; Biology:461.9 ; Combinatorial Mathematics, Includes Graph Theory, Set Theory:921.4 ; Materials Science:951
Cited Times [WOS]:0
|Document Type||Journal Article|
|Department||Department of Materials Science and Engineering|
1.Department of Materials Science and Engineering,Southern University of Science and Technology,Shenzhen,Guangdong,China
2.Department of Prosthodontics,Stomatology Center,Peking University Shenzhen Hospital,Shenzhen,Guangdong,China
|First Author Affilication||Department of Materials Science and Engineering|
|Corresponding Author Affilication||Department of Materials Science and Engineering|
|First Author's First Affilication||Department of Materials Science and Engineering|
Zhu，Mingyu,Zhang，Rui,Mao，Zhixiang,et al. Topographical biointerface regulating cellular functions for bone tissue engineering[J]. Biosurface and Biotribology,2022,8:165-187.
Zhu，Mingyu,Zhang，Rui,Mao，Zhixiang,Fang，Ju,&Ren，Fuzeng.(2022).Topographical biointerface regulating cellular functions for bone tissue engineering.Biosurface and Biotribology,8,165-187.
Zhu，Mingyu,et al."Topographical biointerface regulating cellular functions for bone tissue engineering".Biosurface and Biotribology 8(2022):165-187.
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