中文版 | English
Title

Topographical biointerface regulating cellular functions for bone tissue engineering

Author
Corresponding AuthorFang,Ju; Ren,Fuzeng
Publication Years
2022
DOI
Source Title
EISSN
2405-4518
Volume8Pages:165-187
Abstract
The physiochemical properties of the implant interface significantly influence cell growth, differentiation, cellular matrix deposition, and mineralisation, and eventually, determine the bone regeneration efficiency. Cells directly sense and respond to the physical, chemical, and mechanical cues of the implant surface, and it is increasingly recognized that surface topography can evoke specific cellular responses, conferring biological functions on substrate materials and regulating tissue regeneration. Current progress towards the fundamental understanding of the interplay between the cell and topographical surface has been made by combined advance in fabrication technologies and cell biology. Particularly, the precise fabrication and control of nano/microscale topographies can provide the fundamental knowledge of the mechanotransduction process that governs the cellular response as well as the knowledge of how the specific features drive cells towards a defined differentiation outcome. In this review, we first introduce common techniques and substrate materials for designing and fabricating micro/nano-topographical surfaces for bone regeneration. We then illustrate the intrinsic relationship of topological cues, cellular signal transduction, and cell functions and fates in osteogenic differentiation. Finally, we discuss the challenges and the future of using topological cues as a cell therapy to direct bone tissue regeneration.
URL[Source Record]
Indexed By
Language
English
SUSTech Authorship
First ; Corresponding
EI Accession Number
20223412595564
EI Keywords
Bone ; Cell proliferation ; Signal transduction ; Topography ; Topology
ESI Classification Code
Biomedical Engineering:461.1 ; Biological Materials and Tissue Engineering:461.2 ; Biology:461.9 ; Combinatorial Mathematics, Includes Graph Theory, Set Theory:921.4 ; Materials Science:951
Scopus EID
2-s2.0-85135897478
Data Source
Scopus
Citation statistics
Cited Times [WOS]:0
Document TypeJournal Article
Identifierhttp://kc.sustech.edu.cn/handle/2SGJ60CL/382637
DepartmentDepartment of Materials Science and Engineering
Affiliation
1.Department of Materials Science and Engineering,Southern University of Science and Technology,Shenzhen,Guangdong,China
2.Department of Prosthodontics,Stomatology Center,Peking University Shenzhen Hospital,Shenzhen,Guangdong,China
First Author AffilicationDepartment of Materials Science and Engineering
Corresponding Author AffilicationDepartment of Materials Science and Engineering
First Author's First AffilicationDepartment of Materials Science and Engineering
Recommended Citation
GB/T 7714
Zhu,Mingyu,Zhang,Rui,Mao,Zhixiang,et al. Topographical biointerface regulating cellular functions for bone tissue engineering[J]. Biosurface and Biotribology,2022,8:165-187.
APA
Zhu,Mingyu,Zhang,Rui,Mao,Zhixiang,Fang,Ju,&Ren,Fuzeng.(2022).Topographical biointerface regulating cellular functions for bone tissue engineering.Biosurface and Biotribology,8,165-187.
MLA
Zhu,Mingyu,et al."Topographical biointerface regulating cellular functions for bone tissue engineering".Biosurface and Biotribology 8(2022):165-187.
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