| Title | 哌啶酮化合物的制备方法 |
| Alternative Title | Preparation method of piperidone compound
|
| Author | |
| First Inventor | 舒伟
|
| Original applicant | 南方科技大学
|
| First applicant | 南方科技大学
|
| Address of First applicant | 518055 广东省深圳市南山区学苑大道1088号
|
| Current applicant | 南方科技大学
|
| Address of Current applicant | 518055 广东省深圳市南山区学苑大道1088号
|
| First Current Applicant | 南方科技大学
|
| Address of First Current Applicant | 518055 广东省深圳市南山区学苑大道1088号
|
| Application Number | CN202110792285.7
|
| Application Date | 2021-07-13
|
| Open (Notice) Number | CN113461599A
|
| Date Available | 2021-10-01
|
| Status of Patent | 实质审查
|
| Legal Date | 2021-10-26
|
| Subtype | 发明申请
|
| SUSTech Authorship | First
; Corresponding
|
| Abstract | 本发明公开了一种哌啶酮化合物的制备方法，于光照下，使式(1)化合物、式(2)化合物和无机铵盐在式(4)所示光敏剂的存在下于有机溶剂中反应，得到式(3)化合物，该方法通过非金属参与的[1+2+3]三组分反应制备哌啶酮化合物，具有原料廉价易得、官能团兼容性广、绿色高效且成本低的优点。此外本发明还提供式(3)所示哌啶酮化合物，为含有该类核心骨架的活性分子的全合成提供方法学基础，具有重要的潜在应用价值。 |
| Other Abstract | The invention discloses a preparation method of a piperidone compound, and the method is characterized in that a compound of a formula (1), a compound of a formula (2) and an inorganic ammonium salt react in an organic solvent in the presence of a photosensitizer as shown in a formula (4) under illumination to obtain a compound of a formula (3), and the piperidone compound is prepared through a [1 + 2 + 3] three-component reaction in which nonmetal participates. The method has the advantages of cheap and easily available raw materials, wide compatibility of functional groups, greenness, high efficiency and low cost. In addition, the invention also provides a piperidone compound as shown in a formula (3), a methodological basis is provided for total synthesis of active molecules containing the core skeleton, and the piperidone compound has important potential application value. |
| CPC Classification Number | C07D211/76
; C07D409/04
; C07D221/04
; C07D491/048
; C07D221/22
; C07D405/06
; C07J43/003
; C07D211/78
; C07F7/1892
|
| IPC Classification Number | C07D211/76
; C07D409/04
; C07D221/04
; C07D491/048
; C07D221/22
; C07D405/06
; C07J43/00
; C07D211/78
; C07F7/18
|
| Language | Chinese
|
| INPADOC Legal Status | （ENTRY INTO FORCE OF REQUEST FOR SUBSTANTIVE EXAMINATION）[2021-10-26][CN]
|
| INPADOC Patent Family Count | 1
|
| Extended Patent Family Count | 1
|
| Patent Agent | 江丽娇
|
| Agency | 广东金泰智汇专利商标代理事务所(普通合伙)
|
| URL | [Source Record] |
| Data Source | PatSnap
|
| Document Type | Patent |
| Identifier | http://kc.sustech.edu.cn/handle/2SGJ60CL/393343 |
| Department | Department of Chemistry |
| Recommended Citation GB/T 7714 |
舒伟,杜一丹. 哌啶酮化合物的制备方法.
|
| Files in This Item: | ||||||
| File Name/Size | DocType | Version | Access | License | ||
| 2021107922857（受通）哌啶酮（49KB） | Restricted Access | -- | ||||
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