烯丙基化偶联反应方法及其应用

本发明公开了一种新颖的烯丙基化偶联反应方法：以烯基噻蒽盐为烯丙基化试剂，分别以羧酸类化合物、有机胺为底物在碱的存在下，或者直接以羧酸盐类化合物、芳烃/杂环烃为底物，室温条件下，在有机溶剂中反应，得到烯丙基化偶联产物；该制备方法条件温和，无过渡金属参与，可以高效实现各类烯丙基酯、烯丙基取代胺和烯丙基取代芳烃/杂环烃化合物的制备，在精细化工、材料科学和制药领域都有理想的应用前景。

The invention discloses a novel allylation coupling reaction method. The method comprises the following steps: with alkenyl thianthrene salt as an allylation reagent, respectively with a carboxylic acid compound and organic amine as substrates, in the presence of alkali, or directly with a carboxylate compound and aromatic hydrocarbon/heterocyclic hydrocarbon as substrates, reacting in an organic solvent at room temperature to obtain an allylation coupling product. The preparation method has the advantages of mild conditions and no transition metal participation, can efficiently realize the preparation of various allyl esters, allyl substituted amines and allyl substituted aromatic hydrocarbon/heterocyclic hydrocarbon compounds, and has ideal application prospects in the fields of fine chemical engineering, material science and pharmacy.