Surface Plasmon-Enhanced NIR-II Fluorescence in a Multilayer Nanoprobe for Through-Skull Mouse Brain Imaging

Peng, Lan1; Liu, Ye1; Zhang, Jing1; Zhang, Zhe1; Liu, Zhihe1; Fang, Xiaofeng1; Wang, Yingjie2; Wu, Changfeng1

2022-08-01

10.1021/acsami.2c11218

ACS Applied Materials & Interfaces   Impact Factor & Quartile

1944-8244

1944-8252

Fluorescence imaging in the second near-infrared window (NIR-II, 10001700 nm) holds great potential for the accurate visualization of deeply located biological structures in vivo. However, the weak fluorescence of current NIR-II fluorophores remains a long-standing challenge for the ever-growing imaging demand. Here, we describe a surface plasmon-enhanced NIR-II fluorescence strategy by incorporating silica-coated gold nanorods (GNRs) and polymer dots (Pdots) into a multilayer nanostructure. Precise manipulation of the silica spacing layer thickness signifies an optimum distance of 8.6 nm, where an enhancement factor of up to 6.4 is achieved in the NIR-II imaging window. The surface plasmon enhancement approach is successfully extended to several types of Pdots fluorophores with NIR-II emission. We finally perform outer-layer encapsulation and PEGylation for the multilayer probes and demonstrate surface plasmon-enhanced NIR-II fluorescence for mouse brain imaging through the skull, which exhibits a refined signal-to-background ratio and penetration depth as compared to the clinically approved ICG dye.

NIR-II fluorescence surface plasmon fluorescent imaging gold nanorods polymer dots

SCI ; EI

English

First ; Corresponding

National Key R&D Program of China[2020YFA0909000] ; Shenzhen Science and Technology Program["KQTD20170810111314625","JCYJ20210324115807021"] ; Shenzhen Bay Laboratory[SZBL2021080601002] ; Guangdong Provincial Key Laboratory of Advanced Bio-materials[2022B1212010003]

Science & Technology - Other Topics ; Materials Science

Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary

WOS:000844365600001

AMER CHEMICAL SOC

20223512648634

Brain mapping ; Fluorescence imaging ; Gold coatings ; Infrared devices ; Multilayers ; Nanorods ; Silica ; Surface plasmons

Biomedical Engineering:461.1 ; Light/Optics:741.1 ; Imaging Techniques:746 ; Nanotechnology:761 ; Physical Chemistry:801.4 ; Coating Materials:813.2 ; Plasma Physics:932.3 ; Solid State Physics:933

Web of Science

1.Southern Univ Sci & Technol, Dept Biomed Engn, Guangdong Prov Key Lab Adv Biomat, Shenzhen 518055, Guangdong, Peoples R China
2.Shenzhen Bay Lab, Shenzhen 518132, Guangdong, Peoples R China

Peng, Lan,Liu, Ye,Zhang, Jing,et al. Surface Plasmon-Enhanced NIR-II Fluorescence in a Multilayer Nanoprobe for Through-Skull Mouse Brain Imaging[J]. ACS Applied Materials & Interfaces,2022,14:38575-38583.

Peng, Lan.,Liu, Ye.,Zhang, Jing.,Zhang, Zhe.,Liu, Zhihe.,...&Wu, Changfeng.(2022).Surface Plasmon-Enhanced NIR-II Fluorescence in a Multilayer Nanoprobe for Through-Skull Mouse Brain Imaging.ACS Applied Materials & Interfaces,14,38575-38583.

Peng, Lan,et al."Surface Plasmon-Enhanced NIR-II Fluorescence in a Multilayer Nanoprobe for Through-Skull Mouse Brain Imaging".ACS Applied Materials & Interfaces 14(2022):38575-38583.