中文版 | English
Title

New Wine in an Old Bottle: Utilizing Chemical Genetics to Dissect Apical Hook Development

Author
Corresponding AuthorGuo, Hongwei; Jiang, Kai
Publication Years
2022-08-01
DOI
Source Title
EISSN
2075-1729
Volume12Issue:8
Abstract
The apical hook is formed by dicot seedlings to protect the tender shoot apical meristem during soil emergence. Regulated by many phytohormones, the apical hook has been taken as a model to study the crosstalk between individual signaling pathways. Over recent decades, the roles of different phytohormones and environmental signals in apical hook development have been illustrated. However, key regulators downstream of canonical hormone signaling have rarely been identified via classical genetics screening, possibly due to genetic redundancy and/or lethal mutation. Chemical genetics that utilize small molecules to perturb and elucidate biological processes could provide a complementary strategy to overcome the limitations in classical genetics. In this review, we summarize current progress in hormonal regulation of the apical hook, and previously reported chemical tools that could assist the understanding of this complex developmental process. We also provide insight into novel strategies for chemical screening and target identification, which could possibly lead to discoveries of new regulatory components in apical hook development, or unidentified signaling crosstalk that is overlooked by classical genetics screening.
Keywords
URL[Source Record]
Indexed By
Language
English
SUSTech Authorship
First ; Corresponding
Funding Project
National Natural Science Foundation of China["21,907,049","31911540070"] ; Guangdong Innovative and Entrepreneurial Research Team Program[2016ZT06S172] ; Shenzhen Science and Technology Program["KYTDPT20181011104005","KQTD20190929173906742"]
WOS Research Area
Life Sciences & Biomedicine - Other Topics ; Microbiology
WOS Subject
Biology ; Microbiology
WOS Accession No
WOS:000845569700001
Publisher
Data Source
Web of Science
Citation statistics
Cited Times [WOS]:1
Document TypeJournal Article
Identifierhttp://kc.sustech.edu.cn/handle/2SGJ60CL/394287
DepartmentSUSTech-Peking University National Institute of Plants and Food
生命科学学院
生命科学学院_生物系
Affiliation
1.Southern Univ Sci & Technol SUSTech, Inst Plant & Food Sci, Sch Life Sci, Dept Biol, Shenzhen 518055, Peoples R China
2.Southern Univ Sci & Technol, Key Lab Mol Design Plant Cell Factory Guangdong H, Shenzhen 518055, Peoples R China
First Author AffilicationSUSTech-Peking University National Institute of Plants and Food;  Department of Biology;  School of Life Sciences;  Southern University of Science and Technology
Corresponding Author AffilicationSUSTech-Peking University National Institute of Plants and Food;  Department of Biology;  School of Life Sciences;  Southern University of Science and Technology;  
First Author's First AffilicationSUSTech-Peking University National Institute of Plants and Food;  Department of Biology;  School of Life Sciences
Recommended Citation
GB/T 7714
Aizezi, Yalikunjiang,Xie, Yinpeng,Guo, Hongwei,et al. New Wine in an Old Bottle: Utilizing Chemical Genetics to Dissect Apical Hook Development[J]. LIFE-BASEL,2022,12(8).
APA
Aizezi, Yalikunjiang,Xie, Yinpeng,Guo, Hongwei,&Jiang, Kai.(2022).New Wine in an Old Bottle: Utilizing Chemical Genetics to Dissect Apical Hook Development.LIFE-BASEL,12(8).
MLA
Aizezi, Yalikunjiang,et al."New Wine in an Old Bottle: Utilizing Chemical Genetics to Dissect Apical Hook Development".LIFE-BASEL 12.8(2022).
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