中文版 | English
Title

Mesoporous silica-coated silver nanoparticles as ciprofloxacin/siRNA carriers for accelerated infected wound healing

Author
Corresponding AuthorYang,Chengbin; Liu,Jia; Lin,Suxia
Publication Years
2022-12-01
DOI
Source Title
EISSN
1477-3155
Volume20Issue:1
Abstract
The colonization of bacterial pathogens is a major concern in wound infection and becoming a public health issue. Herein, a core–shell structured Ag@MSN (silver core embedded with mesoporous silica, AM)-based nanoplatform was elaborately fabricated to co-load ciprofloxacin (CFL) and tumor necrosis factor-α (TNF-α) small interfering RNA (siTNF-α) (AMPC@siTNF-α) for treating the bacterial-infected wound. The growth of bacterial pathogens was mostly inhibited by released silver ions (Ag) and CFL from AMPC@siTNF-α. Meanwhile, the loaded siTNF-α was internalized by macrophage cells, which silenced the expression of TNF-α (a pro-inflammatory cytokine) in macrophage cells and accelerated the wound healing process by reducing inflammation response. In the in vivo wound model, the Escherichia coli (E. coli)-infected wound in mice almost completely disappeared after treatment with AMPC@siTNF-α, and no suppuration symptom was observed during the course of the treatment. Importantly, this nanoplatform had negligible side effects both in vitro and in vivo. Taken together, this study strongly demonstrates the promising potential of AMPC@siTNF-α as a synergistic therapeutic agent for clinical wound infections. Graphical Abstract: [Figure not available: see fulltext.].
Keywords
URL[Source Record]
Indexed By
SCI ; EI
Language
English
SUSTech Authorship
Others
Funding Project
Natural Science Foundation of Guangdong Province[2019A1515012163];National Natural Science Foundation of China[81900264];Science, Technology and Innovation Commission of Shenzhen Municipality[JCYJ20210324130609027];
WOS Accession No
WOS:000843549600002
EI Accession Number
20223512641190
EI Keywords
Antibiotics ; Cell death ; Macrophages ; Mammals ; Mesoporous materials ; Metal ions ; Silica ; Silver nanoparticles
ESI Classification Code
Medicine and Pharmacology:461.6 ; Biology:461.9 ; Immunology:461.9.1 ; Metallurgy:531.1 ; Nanotechnology:761
Scopus EID
2-s2.0-85136366411
Data Source
Scopus
Citation statistics
Cited Times [WOS]:5
Document TypeJournal Article
Identifierhttp://kc.sustech.edu.cn/handle/2SGJ60CL/394957
DepartmentSouthern University of Science and Technology Hospital
Affiliation
1.Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging,School of Biomedical Engineering,Health Science Center,Shenzhen University,Shenzhen,518060,China
2.Central Laboratory,The Second Affiliated Hospital,School of Medicine,Longgang District People’s Hospital of Shenzhen,The Chinese University of Hong Kong,Shenzhen,518172,China
3.Dermatology Department,Southern University of Science and Technology Hospital (SUSTech Hospital),Shenzhen,518055,China
4.Center of Assisted Reproduction and Embryology,The University of Hong Kong-Shenzhen Hospital,Shenzhen,518048,China
Recommended Citation
GB/T 7714
Liu,Qiqi,Zhang,Ying,Huang,Jingkai,et al. Mesoporous silica-coated silver nanoparticles as ciprofloxacin/siRNA carriers for accelerated infected wound healing[J]. Journal of Nanobiotechnology,2022,20(1).
APA
Liu,Qiqi.,Zhang,Ying.,Huang,Jingkai.,Xu,Zhourui.,Li,Xiang.,...&Lin,Suxia.(2022).Mesoporous silica-coated silver nanoparticles as ciprofloxacin/siRNA carriers for accelerated infected wound healing.Journal of Nanobiotechnology,20(1).
MLA
Liu,Qiqi,et al."Mesoporous silica-coated silver nanoparticles as ciprofloxacin/siRNA carriers for accelerated infected wound healing".Journal of Nanobiotechnology 20.1(2022).
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