Hybrid composites with magnesium-containing glycosaminoglycans as a chondroconducive matrix for osteoarthritic cartilage repair

Wu，Guofeng1,2,3; Ma，Fenbo3; Liu，Zhengwei1,3; Liu，Jiayi3; Xue，Yizhebang3; Zhang，Mengdi5; Wen，Chunyi6; Tang，Bin3,4; Lin，Lijun1

2022-11-01

10.1016/j.ijbiomac.2022.08.071

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES   Impact Factor & Quartile

0141-8130

1879-0003

The alteration of the extracellular matrix (ECM) homeostasis plays an important role in the development of osteoarthritis (OA). The pathological changes of OA are mainly manifested in the large reduction of components in ECM, like type II collagen and aggrecan, especially hyaluronic acid and chondroitin sulfate and often accompanied by inflammation. Rebuilding ECM and inhibiting inflammation may reverse OA progression. In this work, we developed new magnesium-containing glycosaminoglycans (Mg-GAGs), to create a positive ECM condition for promoting cartilage regeneration and alleviating OA. In vitro results suggested that the introduction of Mg-GAGs contributed to promoting chondrocyte proliferation and facilitated upregulating chondrogenic genes and suppressed inflammation-related factors. Moreover, Mg-GAGs exhibited positive effects on suppressing synovial inflammation, reducing chondrocyte apoptosis and preserving the subchondral bone in the ACLT-induced OA rabbit model. This study provides new insight into ECM-based therapeutic strategy and opens a new avenue for the development of novel OA treatment.

Extracellular matrix Glycosaminoglycans Magnesium

SCI

English

Corresponding

National Key Research and Development Program of China[2019YFA0906004];

Biochemistry & Molecular Biology ; Chemistry ; Polymer Science

Biochemistry & Molecular Biology ; Chemistry, Applied ; Polymer Science

WOS:000857295600003

ELSEVIER

BIOLOGY & BIOCHEMISTRY

2-s2.0-85136653586

Scopus

1.Department of Joint and Orthopedics,Zhujiang Hospital,Southern Medical University,Guangzhou,Guangdong,China
2.Department of Orthopedics,Southern University of Science and Technology Hospital,Shenzhen,Guangdong,China
3.Department of Biomedical Engineering,Southern University of Science and Technology,Shenzhen,Guangdong,China
4.Guangdong Provincial Key Laboratory of Cell Microenvironment and Disease Research,China
5.Department of Sports Medicine,Peking University Shenzhen Hospital,Shenzhen,Guangdong,China
6.Department of Biomedical Engineering,Faculty of Engineering,The Hong Kong Polytechnic University,Kowloon,Hong Kong

Wu，Guofeng,Ma，Fenbo,Liu，Zhengwei,et al. Hybrid composites with magnesium-containing glycosaminoglycans as a chondroconducive matrix for osteoarthritic cartilage repair[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2022,220:1104-1113.

Wu，Guofeng.,Ma，Fenbo.,Liu，Zhengwei.,Liu，Jiayi.,Xue，Yizhebang.,...&Lin，Lijun.(2022).Hybrid composites with magnesium-containing glycosaminoglycans as a chondroconducive matrix for osteoarthritic cartilage repair.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,220,1104-1113.

Wu，Guofeng,et al."Hybrid composites with magnesium-containing glycosaminoglycans as a chondroconducive matrix for osteoarthritic cartilage repair".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 220(2022):1104-1113.