Long-term PM2.5 exposure in association with chronic respiratory diseases morbidity: A cohort study in Northern China
|Corresponding Author||Tang，Nai jun|
Several literatures have examined the risk of chronic respiratory diseases in association with short-term ambient PM exposure in China. However, little evidence has examined the chronic impacts of PM exposure on morbidity of chronic respiratory diseases in cohorts from high pollution countries. Our study aims to investigate the associations. Based on a retrospective cohort among adults in northern China, a Cox regression model with time-varying PM exposure and a concentration-response (C-R) curve model were performed to access the relationships between incidence of chronic respiratory diseases and long-term PM exposure during a mean follow-up time of 9.8 years. Individual annual average PM estimates were obtained from a satellite-based model with high resolution. The incident date of a chronic respiratory disease was identified according to self-reported physician diagnosis time and/or intake of medication for treatment. Among 38,047 urban subjects analyzed in all-cause chronic respiratory disease cohort, 482 developed new cases. In CB (38,369), asthma (38,783), and COPD (38,921) cohorts, the onsets were 276, 89, and 14, respectively. After multivariable adjustment, hazard ratio and 95% confidence interval for morbidity of all-cause chronic respiratory disease, CB, asthma, and COPD were 1.15 (1.01, 1.31), 1.20 (1.00, 1.42), 0.76 (0.55, 1.04), and 0.66 (0.29, 1.47) with each 10 μg/m increment in PM, respectively. Stronger effect estimates were suggested in alcohol drinkers across stratified analyses. Additionally, the shape of C-R curve showed an increasing linear relationship before 75.00 μg/m concentrations of PM for new-onset all-cause chronic respiratory disease, and leveled off at higher levels. These findings indicated that long-term exposure to high-level PM increased the risks of incident chronic respiratory diseases in China. Further evidence of C-R curves is warranted to clarify the associations of adverse chronic respiratory outcomes involving air pollution.
National Institutes of Health[1R01ES032140] ; National Key Research and Development Program of China[2017YFC0211600] ; National Key Research and Development Program of China[2017YFC0211605] ; National Key Research and Development Program of China[2017YFC0211704]
|WOS Research Area|
Environmental Sciences & Ecology ; Toxicology
Environmental Sciences ; Toxicology
|WOS Accession No|
|ESI Research Field|
Cited Times [WOS]:4
|Document Type||Journal Article|
|Department||School of Public Health and Emergency Management|
1.Department of Occupational and Environmental Health,School of Public Health,Tianjin Medical University,Tianjin,300070,China
2.School of Public Health,Chengdu University of Traditional Chinese Medicine,Chengdu,610075,China
3.Tianjin Key Laboratory of Environment,Nutrition and Public Health,Tianjin,300070,China
4.Center for International Collaborative Research on Environment,Nutrition and Public Health,Tianjin,300070,China
5.Department of Epidemiology,Fuwai Hospital,National Center for Cardiovascular Diseases,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing,100037,China
6.School of Public Health and Emergency Management,Southern University of Science and Technology,Shenzhen,518055,China
7.Department of Preventive Medicine,School of Public Health,Sun Yat-sen University,Guangzhou,510080,China
8.School of Medicine and Life Sciences,Shandong Academy of Medical Sciences,Jinan,250062,China
9.Department of Occupational and Environmental Health,School of Public Health,China Medical University,Shenyang,110122,China
10.School of Public Health,Shanxi Medical University,Taiyuan,030001,China
11.Taiyuan Center for Disease Control and Prevention,Taiyuan,030001,China
12.Tianjin Center for Disease Control and Prevention,Tianjin,300011,China
13.Gangarosa Department of Environmental Health,Rollins School of Public Health,Emory University,Atlanta,30322,United States
Yan，Mengfan,Ge，Han,Zhang，Liwen,et al. Long-term PM2.5 exposure in association with chronic respiratory diseases morbidity: A cohort study in Northern China[J]. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,2022,244.
Yan，Mengfan.,Ge，Han.,Zhang，Liwen.,Chen，Xi.,Yang，Xueli.,...&Tang，Nai jun.(2022).Long-term PM2.5 exposure in association with chronic respiratory diseases morbidity: A cohort study in Northern China.ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,244.
Yan，Mengfan,et al."Long-term PM2.5 exposure in association with chronic respiratory diseases morbidity: A cohort study in Northern China".ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY 244(2022).
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