| Title | Copper-catalyzed radical trans-selective hydroboration of ynamides with N-heterocyclic carbene boranes |
| Author | |
| Corresponding Author | Xu，Jing; Wang，Yukun |
| Publication Years | 2022-09-16
|
| DOI | |
| Source Title | |
| EISSN | 2589-0042
|
| Volume | 25Issue:9 |
| Abstract | Vinylboron compounds are important compounds in organic chemistry and biology. In this communication, we developed a copper(I)-catalyzed, highly regio- and stereoselective radical trans-hydroboration of ynamides with N-heterocyclic carbene (NHC)-ligated borane is reported, which leads to a series of trans-boryl enmides that can be conveniently transformed into various multi-substituted enamides. Further investigation showcased that our method is robust and scalable. The mechanism of this unique reaction is studied and discussed. |
| Keywords | |
| URL | [Source Record] |
| Indexed By | |
| Language | English
|
| SUSTech Authorship | First
; Corresponding
|
| Funding Project | Guangdong Provincial Key Laboratory Of Catalysis[2020B121201002]
|
| Scopus EID | 2-s2.0-85136576290
|
| Data Source | Scopus
|
| Citation statistics |
Cited Times [WOS]:0
|
| Document Type | Journal Article |
| Identifier | http://kc.sustech.edu.cn/handle/2SGJ60CL/395054 |
| Department | Department of Pharmacology 南方科技大学医学院 理学院_化学系 深圳格拉布斯研究院 南方科技大学医院 |
| Affiliation | 1.Department of Pharmacology,School of Medicine,Southern University of Science and Technology,Shenzhen,518055,China 2.Department of Pharmacy,Southern University of Science and Technology Hospital,Shenzhen,518055,China 3.Department of Chemistry and Shenzhen Grubbs Institute and Guangdong Provincial Key Laboratory of Catalysis and Shenzhen Key Laboratory of Small Molecule Drug Discovery and Synthesis,Southern University of Science and Technology,Shenzhen,518055,China 4.Clinical Medical Research Center,Southern University of Science and Technology Hospital,Shenzhen,518055,China |
| First Author Affilication | Department of Pharmacology; School of Medicine |
| Corresponding Author Affilication | Department of Chemistry; Shenzhen Grubbs Institute; Department of Pharmacology; School of Medicine; Southern University of Science and Technology Hospital |
| First Author's First Affilication | Department of Pharmacology; School of Medicine |
| Recommended Citation GB/T 7714 |
Wang，Kefeng,Yu，Qingzhen,Mao，Wenli,et al. Copper-catalyzed radical trans-selective hydroboration of ynamides with N-heterocyclic carbene boranes[J]. iScience,2022,25(9).
|
| APA |
Wang，Kefeng,Yu，Qingzhen,Mao，Wenli,Zheng，Yuxin,Xu，Jing,&Wang，Yukun.(2022).Copper-catalyzed radical trans-selective hydroboration of ynamides with N-heterocyclic carbene boranes.iScience,25(9).
|
| MLA |
Wang，Kefeng,et al."Copper-catalyzed radical trans-selective hydroboration of ynamides with N-heterocyclic carbene boranes".iScience 25.9(2022).
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| Files in This Item: | ||||||
| File Name/Size | DocType | Version | Access | License | ||
| Copper-catalyzed rad（2264KB） | Open Access | -- | View | |||
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