中文版 | English
Title

Copper-catalyzed radical trans-selective hydroboration of ynamides with N-heterocyclic carbene boranes

Author
Corresponding AuthorXu,Jing; Wang,Yukun
Publication Years
2022-09-16
DOI
Source Title
EISSN
2589-0042
Volume25Issue:9
Abstract

Vinylboron compounds are important compounds in organic chemistry and biology. In this communication, we developed a copper(I)-catalyzed, highly regio- and stereoselective radical trans-hydroboration of ynamides with N-heterocyclic carbene (NHC)-ligated borane is reported, which leads to a series of trans-boryl enmides that can be conveniently transformed into various multi-substituted enamides. Further investigation showcased that our method is robust and scalable. The mechanism of this unique reaction is studied and discussed.

Keywords
URL[Source Record]
Indexed By
Language
English
SUSTech Authorship
First ; Corresponding
Funding Project
Guangdong Provincial Key Laboratory Of Catalysis[2020B121201002]
Scopus EID
2-s2.0-85136576290
Data Source
Scopus
Citation statistics
Cited Times [WOS]:0
Document TypeJournal Article
Identifierhttp://kc.sustech.edu.cn/handle/2SGJ60CL/395054
DepartmentDepartment of Pharmacology
南方科技大学医学院
理学院_化学系
深圳格拉布斯研究院
南方科技大学医院
Affiliation
1.Department of Pharmacology,School of Medicine,Southern University of Science and Technology,Shenzhen,518055,China
2.Department of Pharmacy,Southern University of Science and Technology Hospital,Shenzhen,518055,China
3.Department of Chemistry and Shenzhen Grubbs Institute and Guangdong Provincial Key Laboratory of Catalysis and Shenzhen Key Laboratory of Small Molecule Drug Discovery and Synthesis,Southern University of Science and Technology,Shenzhen,518055,China
4.Clinical Medical Research Center,Southern University of Science and Technology Hospital,Shenzhen,518055,China
First Author AffilicationDepartment of Pharmacology;  School of Medicine
Corresponding Author AffilicationDepartment of Chemistry;  Shenzhen Grubbs Institute;  Department of Pharmacology;  School of Medicine;  Southern University of Science and Technology Hospital
First Author's First AffilicationDepartment of Pharmacology;  School of Medicine
Recommended Citation
GB/T 7714
Wang,Kefeng,Yu,Qingzhen,Mao,Wenli,et al. Copper-catalyzed radical trans-selective hydroboration of ynamides with N-heterocyclic carbene boranes[J]. iScience,2022,25(9).
APA
Wang,Kefeng,Yu,Qingzhen,Mao,Wenli,Zheng,Yuxin,Xu,Jing,&Wang,Yukun.(2022).Copper-catalyzed radical trans-selective hydroboration of ynamides with N-heterocyclic carbene boranes.iScience,25(9).
MLA
Wang,Kefeng,et al."Copper-catalyzed radical trans-selective hydroboration of ynamides with N-heterocyclic carbene boranes".iScience 25.9(2022).
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