中文版 | English
Title

Extracellular pH sensing by plant cell-surface peptide-receptor complexes

Author
Corresponding AuthorChai,Jijie; Guo,Hongwei
Publication Years
2022-09-01
DOI
Source Title
ISSN
0092-8674
EISSN
1097-4172
Volume185Issue:18Pages:3341-3355.e13
Abstract
The extracellular pH is a vital regulator of various biological processes in plants. However, how plants perceive extracellular pH remains obscure. Here, we report that plant cell-surface peptide-receptor complexes can function as extracellular pH sensors. We found that pattern-triggered immunity (PTI) dramatically alkalinizes the acidic extracellular pH in root apical meristem (RAM) region, which is essential for root meristem growth factor 1 (RGF1)-mediated RAM growth. The extracellular alkalinization progressively inhibits the acidic-dependent interaction between RGF1 and its receptors (RGFRs) through the pH sensor sulfotyrosine. Conversely, extracellular alkalinization promotes the alkaline-dependent binding of plant elicitor peptides (Peps) to its receptors (PEPRs) through the pH sensor Glu/Asp, thereby promoting immunity. A domain swap between RGFR and PEPR switches the pH dependency of RAM growth. Thus, our results reveal a mechanism of extracellular pH sensing by plant peptide-receptor complexes and provide insights into the extracellular pH-mediated regulation of growth and immunity in the RAM.
Keywords
URL[Source Record]
Indexed By
Language
English
Important Publications
NI Journal Papers
SUSTech Authorship
First ; Corresponding
Funding Project
National Key Research and Development Program of China[2018YFA0507101];National Key Research and Development Program of China[2019YFA0903904];National Natural Science Foundation of China[31421001];National Natural Science Foundation of China[31971119];National Natural Science Foundation of China[91940303];
WOS Research Area
Biochemistry & Molecular Biology ; Cell Biology
WOS Subject
Biochemistry & Molecular Biology ; Cell Biology
WOS Accession No
WOS:000858905600002
Publisher
ESI Research Field
MOLECULAR BIOLOGY & GENETICS
Scopus EID
2-s2.0-85136542729
Data Source
Scopus
Citation statistics
Cited Times [WOS]:18
Document TypeJournal Article
Identifierhttp://kc.sustech.edu.cn/handle/2SGJ60CL/395085
DepartmentSUSTech-Peking University National Institute of Plants and Food
生命科学学院
生命科学学院_生物系
Affiliation
1.Key Laboratory of Molecular Design for Plant Cell Factory of Guangdong Higher Education Institutes,Institute of Plant and Food Science,Department of Biology,Southern University of Science and Technology (SUSTech),Shenzhen,Guangdong,518055,China
2.Max-Planck Institute for Plant Breeding Research,Cologne,50829,Germany
3.Institute of Biochemistry,University of Cologne,Cologne,50923,Germany
4.Innovation Center for Structural Biology,School of Life Sciences,Tsinghua University,Beijing,100084,China
5.SUSTech Academy for Advanced and Interdisciplinary Studies,Southern University of Science and Technology,Shenzhen,Guangdong,518055,China
6.Department of Biotechnology,Graduate School of Agricultural and Life Sciences,The University of Tokyo,Tokyo,1-1-1 Yayoi, Bunkyo-ku,113-8657,Japan
7.Research Laboratory of Biomedical Optics and Molecular Imaging,Institute of Biomedical and Health Engineering,Shenzhen Institutes of Advanced Technology,Chinese Academy of Sciences,Shenzhen,Guangdong,518055,China
First Author AffilicationSUSTech-Peking University National Institute of Plants and Food;  Department of Biology;  School of Life Sciences
Corresponding Author AffilicationSUSTech-Peking University National Institute of Plants and Food;  Department of Biology;  School of Life Sciences
First Author's First AffilicationSUSTech-Peking University National Institute of Plants and Food;  Department of Biology;  School of Life Sciences
Recommended Citation
GB/T 7714
Liu,Li,Song,Wen,Huang,Shijia,et al. Extracellular pH sensing by plant cell-surface peptide-receptor complexes[J]. CELL,2022,185(18):3341-3355.e13.
APA
Liu,Li.,Song,Wen.,Huang,Shijia.,Jiang,Kai.,Moriwaki,Yoshitaka.,...&Guo,Hongwei.(2022).Extracellular pH sensing by plant cell-surface peptide-receptor complexes.CELL,185(18),3341-3355.e13.
MLA
Liu,Li,et al."Extracellular pH sensing by plant cell-surface peptide-receptor complexes".CELL 185.18(2022):3341-3355.e13.
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