From bio-inertness to osseointegration and antibacterial activity: A one-step micro-arc oxidation approach for multifunctional Ti implants fabricated by additive manufacturing

Tang，Jincheng1; Wu，Zhongzhen2; Yao，Xiyu1; Zhou，Yinghao1; Xiong，Yi3; Li，Yulong4; Xu，Jingyuan1,5; Dargusch，Matthew S.5; Yan，Ming1

2022-09-01

10.1016/j.matdes.2022.110962

Materials and Design   Impact Factor & Quartile

0264-1275

1873-4197

Infectious bone defects (IBD) remain a major problem in orthopedics in clinical settings. For IBD repair, implants possessing multiple functions such as osseointegration and antibacterial activity are in demand. This study aims to develop a surface-modified titanium (Ti) implant (MTi/Ag/CaP) with osseointegration and antibacterial functions for IBD repair. The pure Ti implant is printed using a selective laser melting technique, and a two-layer hierarchical structure is formed on its surface using a one-step micro-arc oxidation (MAO) approach. The outer layer is an apatite-like material decorated with Ag nanoparticles, whereas the inner layer is porous TiO. In vitro experiments show that the MTi/Ag/CaP implant can effectively eliminate and inhibit the adhesion and proliferation of bacteria over a long period time while promoting MG-63 cell adhesion, proliferation, and osteogenic differentiation. In vivo experiments further reveal that the MTi/Ag/CaP implant produces more mineralized bone tissue than non-treated samples and interlocks closely with the bone tissue after 8 weeks. The one-step MAO modification developed in this study is simple, efficient, and environment-friendly, which demonstrates great potential as a promising approach for providing advanced biomedical materials in orthopedic applications, including for the prevention and treatment of IBDs.

Antibacterial activity Laser powder bed fusion Micro-arc oxidation Osseointegration Titanium implant

EI

English

First

Booz Allen Foundation[2020A1515011373];

20223112452839

Bone ; Cell adhesion ; Oxidation ; Phosphate minerals ; Repair ; Silver nanoparticles

Biological Materials and Tissue Engineering:461.2 ; Biology:461.9 ; Minerals:482.2 ; Nanotechnology:761 ; Chemical Reactions:802.2 ; Inorganic Compounds:804.2 ; Maintenance:913.5

MATERIALS SCIENCE

2-s2.0-85134882730

Scopus

1.Department of Materials Science and Engineering,Southern University of Science and Technology,Shenzhen,518055,China
2.School of Advanced Materials,Peking University Shenzhen Graduate School,Shenzhen,518055,China
3.School of System Design and Intelligent Manufacturing,Southern University of Science and Technology,Shenzhen,518055,China
4.Key Lab for Robot &Welding Automation of Jiangxi Province,Mechanical and Electrical Engineering School,Nanchang University,Nanchang,330031,China
5.The University of Queensland,School of Mechanical and Mining Engineering,Centre for Advanced Materials Processing and Manufacturing (AMPAM),4072,Australia

Tang，Jincheng,Wu，Zhongzhen,Yao，Xiyu,et al. From bio-inertness to osseointegration and antibacterial activity: A one-step micro-arc oxidation approach for multifunctional Ti implants fabricated by additive manufacturing[J]. Materials and Design,2022,221.

Tang，Jincheng.,Wu，Zhongzhen.,Yao，Xiyu.,Zhou，Yinghao.,Xiong，Yi.,...&Yan，Ming.(2022).From bio-inertness to osseointegration and antibacterial activity: A one-step micro-arc oxidation approach for multifunctional Ti implants fabricated by additive manufacturing.Materials and Design,221.

Tang，Jincheng,et al."From bio-inertness to osseointegration and antibacterial activity: A one-step micro-arc oxidation approach for multifunctional Ti implants fabricated by additive manufacturing".Materials and Design 221(2022).