State-of-the-Art Development in Liquid Crystal Biochemical Sensors

Zhan，Xiyun1,2; Liu，Yanjun1; Yang，Kun Lin2; Luo，Dan1

2022-07-29

10.3390/bios12080577

Biosensors   Impact Factor & Quartile

2079-6374

As an emerging stimuli-responsive material, liquid crystal (LC) has attracted great attentions beyond display applications, especially in the area of biochemical sensors. Its high sensitivity and fast response to various biological or chemical analytes make it possible to fabricate a simple, real-time, label-free, and cost-effective LC-based detection platform. Advancements have been achieved in the development of LC-based sensors, both in fundamental research and practical applications. This paper briefly reviews the state-of-the-art research on LC sensors in the biochemical field, from basic properties of LC material to the detection mechanisms of LC sensors that are categorized into LC-solid, LC-aqueous, and LC droplet platforms. In addition, various analytes detected by LCs are presented as a proof of the application value, including metal ions, nucleic acids, proteins, glucose, and some toxic chemical substances. Furthermore, a machine-learning-assisted LC sensing platform is realized to provide a foundation for device intelligence and automatization. It is believed that a portable, convenient, and user-friendly LC-based biochemical sensing device will be achieved in the future.

biochemical sensor biological analytes chemical analytes high sensitivity label free liquid crystal machine learning stimuli-responsive material

SCI

English

First

National Natural Science Foundation of China[61875081];National Natural Science Foundation of China[62175098];

Chemistry ; Science & Technology - Other Topics ; Instruments & Instrumentation

Chemistry, Analytical ; Nanoscience & Nanotechnology ; Instruments & Instrumentation

WOS:000847019700001

MDPI

2-s2.0-85136528758

Scopus

1.Department of Electrical and Electronic Engineering,Southern University of Science and Technology,Shenzhen,Xueyuan Road 1088,518055,China
2.Department of Chemical and Biomolecular Engineering,National University of Singapore,4 Engineering Drive 4,117576,Singapore

Zhan，Xiyun,Liu，Yanjun,Yang，Kun Lin,et al. State-of-the-Art Development in Liquid Crystal Biochemical Sensors[J]. Biosensors,2022,12(8).

Zhan，Xiyun,Liu，Yanjun,Yang，Kun Lin,&Luo，Dan.(2022).State-of-the-Art Development in Liquid Crystal Biochemical Sensors.Biosensors,12(8).

Zhan，Xiyun,et al."State-of-the-Art Development in Liquid Crystal Biochemical Sensors".Biosensors 12.8(2022).