Activating the Antibacterial Effect of 4,6-Diamino-2-pyrimidinethiol- Modified Gold Nanoparticles by Reducing their Sizes

Xie，Yangzhouyun1; Yang，Junchuan1; Zhang，Jiangjiang1; Zheng，Wenfu1,2; Jiang，Xingyu1

2020

10.1002/ANGE.202008584

ADVANCED MATERIALS   Impact Factor & Quartile

0935-9648

1521-4095

Adequately decorated gold nanoparticles (GNPs) have excellent antibiotic activities against multidrug-resistant (MDR) bacteria. Nanoparticles exhibiting Gram selective antibacterial actions are beneficial to precise therapy. Here, we present a strategy to tune the antibacterial spectrum of a small molecule (4,6-diamino-2-pyrimidinethiol, DAPT)- modified GNPs (DAPT-GNPs, DGNPs) by adjusting their sizes. Compared to large (ca. 14 nm diameter) DGNPs (IDGNPs) and medium-sized (3-4 nm diameter) DGNPs (mDGNPs), which have no antibacterial effect or only target Gram-negative (G—) bacteria, ultrasmall DGNPs (uDGNPs, <2 nm) have a broad antibacterial spectrum, especially showing an over 60-fold increase in antibacterial efficacy against Gram-positive (G+) bacteria. Moreover, the uDGNPs-functionalized scaffolds (agarose gel) can serve as general wound dressings for healing burnt infections. Our strategy is insightful for exploring properties of the nano- materials and their applications.

antibacterial activity ultrasmall gold nanoparticles wound dressing

EI

English

NI Journal Papers

First

20223412618021

Bacteria ; Fiber optic sensors ; Metal nanoparticles ; Scaffolds

Construction Equipment:405.1 ; Fiber Optics:741.1.2 ; Nanotechnology:761

MATERIALS SCIENCE

2-s2.0-85136209348

Scopus

1.Department of Biomedical Engineering,Southern University of Science and Technology,Shenzhen,No. 1088 Xueyuan Rd, Nanshan District, Guangdong,518055,China
2.GBA Research Innovation Institute for Nanotechnology,CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety,National Center for NanoScience and Technology,Beijing,No. 11 Zhongguancun Beiyitiao,100190,China

Xie，Yangzhouyun,Yang，Junchuan,Zhang，Jiangjiang,et al. Activating the Antibacterial Effect of 4,6-Diamino-2-pyrimidinethiol- Modified Gold Nanoparticles by Reducing their Sizes[J]. ADVANCED MATERIALS,2020,132(52):23677-23681.

Xie，Yangzhouyun,Yang，Junchuan,Zhang，Jiangjiang,Zheng，Wenfu,&Jiang，Xingyu.(2020).Activating the Antibacterial Effect of 4,6-Diamino-2-pyrimidinethiol- Modified Gold Nanoparticles by Reducing their Sizes.ADVANCED MATERIALS,132(52),23677-23681.

Xie，Yangzhouyun,et al."Activating the Antibacterial Effect of 4,6-Diamino-2-pyrimidinethiol- Modified Gold Nanoparticles by Reducing their Sizes".ADVANCED MATERIALS 132.52(2020):23677-23681.