Activating the Antibacterial Effect of 4,6-Diamino-2-pyrimidinethiol- Modified Gold Nanoparticles by Reducing their Sizes
Adequately decorated gold nanoparticles (GNPs) have excellent antibiotic activities against multidrug-resistant (MDR) bacteria. Nanoparticles exhibiting Gram selective antibacterial actions are beneficial to precise therapy. Here, we present a strategy to tune the antibacterial spectrum of a small molecule (4,6-diamino-2-pyrimidinethiol, DAPT)- modified GNPs (DAPT-GNPs, DGNPs) by adjusting their sizes. Compared to large (ca. 14 nm diameter) DGNPs (IDGNPs) and medium-sized (3-4 nm diameter) DGNPs (mDGNPs), which have no antibacterial effect or only target Gram-negative (G—) bacteria, ultrasmall DGNPs (uDGNPs, <2 nm) have a broad antibacterial spectrum, especially showing an over 60-fold increase in antibacterial efficacy against Gram-positive (G+) bacteria. Moreover, the uDGNPs-functionalized scaffolds (agarose gel) can serve as general wound dressings for healing burnt infections. Our strategy is insightful for exploring properties of the nano- materials and their applications.
NI Journal Papers
|EI Accession Number|
Bacteria ; Fiber optic sensors ; Metal nanoparticles ; Scaffolds
|ESI Classification Code|
Construction Equipment:405.1 ; Fiber Optics:741.1.2 ; Nanotechnology:761
|ESI Research Field|
Cited Times [WOS]:0
|Document Type||Journal Article|
|Department||Department of Biomedical Engineering|
1.Department of Biomedical Engineering,Southern University of Science and Technology,Shenzhen,No. 1088 Xueyuan Rd, Nanshan District, Guangdong,518055,China
2.GBA Research Innovation Institute for Nanotechnology,CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety,National Center for NanoScience and Technology,Beijing,No. 11 Zhongguancun Beiyitiao,100190,China
|First Author Affilication||Department of Biomedical Engineering|
|First Author's First Affilication||Department of Biomedical Engineering|
Xie，Yangzhouyun,Yang，Junchuan,Zhang，Jiangjiang,et al. Activating the Antibacterial Effect of 4,6-Diamino-2-pyrimidinethiol- Modified Gold Nanoparticles by Reducing their Sizes[J]. ADVANCED MATERIALS,2020,132(52):23677-23681.
Xie，Yangzhouyun,Yang，Junchuan,Zhang，Jiangjiang,Zheng，Wenfu,&Jiang，Xingyu.(2020).Activating the Antibacterial Effect of 4,6-Diamino-2-pyrimidinethiol- Modified Gold Nanoparticles by Reducing their Sizes.ADVANCED MATERIALS,132(52),23677-23681.
Xie，Yangzhouyun,et al."Activating the Antibacterial Effect of 4,6-Diamino-2-pyrimidinethiol- Modified Gold Nanoparticles by Reducing their Sizes".ADVANCED MATERIALS 132.52(2020):23677-23681.
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