| Title | Design and Atroposelective Construction of IAN analogues by Organocatalytic Asymmetric Heteroannulation of Alkynes |
| Author | |
| Publication Years | 2020
|
| DOI | |
| Source Title | |
| ISSN | 0935-9648
|
| EISSN | 1521-4095
|
| Volume | 132Issue:51Pages:23277-23282 |
| Abstract | An organocatalytic atroposelective strategy for accessing enantioenriched axially chiral IAN analogues was developed for the first time. A class of novel atropisomeric C2-arylquinoline skeletons were synthesized with high enantiocontrol via chiral phosphoric-acid-catalyzed heteroannulation of in situ generated vinylidene ortho-quinone methide (VQM) intermediates with ortho-aminophenones. The strategy tolerated a broad substrate scope, providing a facile organocatalytic approach to IAN analogues in good yields and excellent enantioselectivities under mild reaction conditions. Moreover, the synthetic utility of this methodology was illustrated through further transformations into IAN-type ligand and axially chiral thiourea. |
| Keywords | |
| URL | [Source Record] |
| Indexed By | |
| Language | English
|
| Important Publications | NI Journal Papers
|
| SUSTech Authorship | Others
|
| EI Accession Number | 20223412618140
|
| EI Keywords | Quinone
|
| ESI Classification Code | Energy Storage:525.7
; Organic Compounds:804.1
; Inorganic Compounds:804.2
|
| ESI Research Field | MATERIALS SCIENCE
|
| Scopus EID | 2-s2.0-85136186461
|
| Data Source | Scopus
|
| Citation statistics |
Cited Times [WOS]:0
|
| Document Type | Journal Article |
| Identifier | http://kc.sustech.edu.cn/handle/2SGJ60CL/395657 |
| Department | Department of Chemistry 深圳格拉布斯研究院 |
| Affiliation | 1.College of Materials,Chemistry and Chemical Engineering,Hangzhou Normal University,Hangzhou,311121,China 2.Shenzhen Grubbs Institute and Department of Chemistry,Southern University of Science and Technology,Shenzhen,518055,China |
| Recommended Citation GB/T 7714 |
Zhang，Lei,Shen，Jiahua,Zhong，Guofu,et al. Design and Atroposelective Construction of IAN analogues by Organocatalytic Asymmetric Heteroannulation of Alkynes[J]. ADVANCED MATERIALS,2020,132(51):23277-23282.
|
| APA |
Zhang，Lei.,Shen，Jiahua.,Zhong，Guofu.,Zhang，Lei.,Wu，San.,...&Tan，Bin.(2020).Design and Atroposelective Construction of IAN analogues by Organocatalytic Asymmetric Heteroannulation of Alkynes.ADVANCED MATERIALS,132(51),23277-23282.
|
| MLA |
Zhang，Lei,et al."Design and Atroposelective Construction of IAN analogues by Organocatalytic Asymmetric Heteroannulation of Alkynes".ADVANCED MATERIALS 132.51(2020):23277-23282.
|
| Files in This Item: | There are no files associated with this item. | |||||
Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.
Edit Comment