中文版 | English
Title

Sub-10 nm Aggregation-Induced Emission Quantum Dots Assembled by Microfluidics for Enhanced Tumor Targeting and Reduced Retention in the Liver

Author
Corresponding AuthorLi,Kai; Jiang,Xingyu
Publication Years
2020
DOI
Source Title
ISSN
0935-9648
EISSN
1521-4095
Volume132Issue:49Pages:22083-22087
Abstract
A robust platform is developed to assemble sub- 10 nm organic aggregation-induced emission (AIE) particles using four different AIE luminogens (AIEgens) with emissions from green to the second near-infrared window (NIR-II). They are called AIE quantum dots (QDs) to distinguish from typical AIE dots which are larger than 25 nm. Compared with AIE dots that are larger than 25 nm, AIE QDs allow more efficient cellular uptake and imaging without surface modification of any membrane-penetrating peptides or other targeting molecules. NIR-II AIEgens, which have nearly no background fluorescence from organisms, are used to demonstrate that AIE QDs can achieve high contrast at the tumor as small as 80 mm and evade the liver more efficiently than AIE dots. AIE QDs hold a good promise for sensitive and precise diagnosis of the latent solid tumor in clinical medicine with much lower offtargeting to the liver than AIE dots.
Keywords
URL[Source Record]
Indexed By
Language
English
Important Publications
NI Journal Papers
SUSTech Authorship
Corresponding
EI Accession Number
20223412618228
EI Keywords
Agglomeration ; Diagnosis ; Fluorescence ; Infrared devices ; Nanocrystals ; Tumors
ESI Classification Code
Biological Materials and Tissue Engineering:461.2 ; Medicine and Pharmacology:461.6 ; Semiconductor Devices and Integrated Circuits:714.2 ; Light/Optics:741.1 ; Nanotechnology:761 ; Chemical Operations:802.3 ; Crystalline Solids:933.1
ESI Research Field
MATERIALS SCIENCE
Scopus EID
2-s2.0-85110105176
Data Source
Scopus
Citation statistics
Cited Times [WOS]:0
Document TypeJournal Article
Identifierhttp://kc.sustech.edu.cn/handle/2SGJ60CL/395658
DepartmentDepartment of Biomedical Engineering
Affiliation
1.The University of Chinese Academy of Sciences,Beijing,No. 11 Zhongguancun Beiyitiao,100190,China
2.Department of Biomedical Engineering,Southern University of Science and Technology,Shenzhen,No. 1088 Xueyuan Rd, Nanshan District, Guangdong,518055,China
First Author AffilicationDepartment of Biomedical Engineering
Corresponding Author AffilicationDepartment of Biomedical Engineering
Recommended Citation
GB/T 7714
Li,Xuanyu,Zha,Menglei,Li,Yaxi,et al. Sub-10 nm Aggregation-Induced Emission Quantum Dots Assembled by Microfluidics for Enhanced Tumor Targeting and Reduced Retention in the Liver[J]. ADVANCED MATERIALS,2020,132(49):22083-22087.
APA
Li,Xuanyu.,Zha,Menglei.,Li,Yaxi.,Ni,Jen Shyang.,Min,Tianliang.,...&Jiang,Xingyu.(2020).Sub-10 nm Aggregation-Induced Emission Quantum Dots Assembled by Microfluidics for Enhanced Tumor Targeting and Reduced Retention in the Liver.ADVANCED MATERIALS,132(49),22083-22087.
MLA
Li,Xuanyu,et al."Sub-10 nm Aggregation-Induced Emission Quantum Dots Assembled by Microfluidics for Enhanced Tumor Targeting and Reduced Retention in the Liver".ADVANCED MATERIALS 132.49(2020):22083-22087.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Export to Excel
Export to Csv
Altmetrics Score
Google Scholar
Similar articles in Google Scholar
[Li,Xuanyu]'s Articles
[Zha,Menglei]'s Articles
[Li,Yaxi]'s Articles
Baidu Scholar
Similar articles in Baidu Scholar
[Li,Xuanyu]'s Articles
[Zha,Menglei]'s Articles
[Li,Yaxi]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Li,Xuanyu]'s Articles
[Zha,Menglei]'s Articles
[Li,Yaxi]'s Articles
Terms of Use
No data!
Social Bookmark/Share
No comment.

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.