Sub-10 nm Aggregation-Induced Emission Quantum Dots Assembled by Microfluidics for Enhanced Tumor Targeting and Reduced Retention in the Liver

Li，Xuanyu1,2; Zha，Menglei2; Li，Yaxi2; Ni，Jen Shyang2; Min，Tianliang2; Kang，Tianyi2; Yang，Guang2; Tang，Hao2; Li，Kai2; Jiang，Xingyu1,2

2020

10.1002/ANGE.202008564

ADVANCED MATERIALS   Impact Factor & Quartile

0935-9648

1521-4095

A robust platform is developed to assemble sub- 10 nm organic aggregation-induced emission (AIE) particles using four different AIE luminogens (AIEgens) with emissions from green to the second near-infrared window (NIR-II). They are called AIE quantum dots (QDs) to distinguish from typical AIE dots which are larger than 25 nm. Compared with AIE dots that are larger than 25 nm, AIE QDs allow more efficient cellular uptake and imaging without surface modification of any membrane-penetrating peptides or other targeting molecules. NIR-II AIEgens, which have nearly no background fluorescence from organisms, are used to demonstrate that AIE QDs can achieve high contrast at the tumor as small as 80 mm and evade the liver more efficiently than AIE dots. AIE QDs hold a good promise for sensitive and precise diagnosis of the latent solid tumor in clinical medicine with much lower offtargeting to the liver than AIE dots.

cancer fluorescence probes nanoparticles synthetic methods

EI

English

NI Journal Papers

Corresponding

20223412618228

Agglomeration ; Diagnosis ; Fluorescence ; Infrared devices ; Nanocrystals ; Tumors

Biological Materials and Tissue Engineering:461.2 ; Medicine and Pharmacology:461.6 ; Semiconductor Devices and Integrated Circuits:714.2 ; Light/Optics:741.1 ; Nanotechnology:761 ; Chemical Operations:802.3 ; Crystalline Solids:933.1

MATERIALS SCIENCE

2-s2.0-85110105176

Scopus

1.The University of Chinese Academy of Sciences,Beijing,No. 11 Zhongguancun Beiyitiao,100190,China
2.Department of Biomedical Engineering,Southern University of Science and Technology,Shenzhen,No. 1088 Xueyuan Rd, Nanshan District, Guangdong,518055,China

Li，Xuanyu,Zha，Menglei,Li，Yaxi,et al. Sub-10 nm Aggregation-Induced Emission Quantum Dots Assembled by Microfluidics for Enhanced Tumor Targeting and Reduced Retention in the Liver[J]. ADVANCED MATERIALS,2020,132(49):22083-22087.

Li，Xuanyu.,Zha，Menglei.,Li，Yaxi.,Ni，Jen Shyang.,Min，Tianliang.,...&Jiang，Xingyu.(2020).Sub-10 nm Aggregation-Induced Emission Quantum Dots Assembled by Microfluidics for Enhanced Tumor Targeting and Reduced Retention in the Liver.ADVANCED MATERIALS,132(49),22083-22087.

Li，Xuanyu,et al."Sub-10 nm Aggregation-Induced Emission Quantum Dots Assembled by Microfluidics for Enhanced Tumor Targeting and Reduced Retention in the Liver".ADVANCED MATERIALS 132.49(2020):22083-22087.