中文版 | English
Title

Metabolomics Reveal Nanoplastic-Induced Mitochondrial Damage in Human Liver and Lung Cells

Author
Corresponding AuthorCai, Zongwei; Zheng, Chunmiao
Publication Years
2022-08-01
DOI
Source Title
ISSN
0013-936X
EISSN
1520-5851
Abstract
Plastic debris in the global biosphere is an increasing concern, and nanoplastic (NPs) toxicity in humans is far from being understood. Studies have indicated that NPs can affect mitochondria, but the underlying mechanisms remain unclear. The liver and lungs have important metabolic functions and are vulnerable to NP exposure. In this study, we investigated the effects of 80 nm NPs on mitochondrial functions and metabolic pathways in normal human hepatic (L02) cells and lung (BEAS-2B) cells. NP exposure did not induce mass cell death; however, transmission electron microscopy analysis showed that the NPs could enter the cells and cause mitochondrial damage, as evidenced by overproduction of mitochondrial reactive oxygen species, alterations in the mitochondrial membrane potential, and suppression of mitochondrial respiration. These alterations were observed at NP concentrations as low as 0.0125 mg/mL, which might be comparable to the environmental levels. Nontarget metabolomics confirmed that the most significantly impacted processes were mitochondrial-related. The metabolic function of L02 cells was more vulnerable to NP exposure than that of BEAS-2B cells, especially at low NP concentrations. This study identifies NP-induced mitochondrial dysfunction and metabolic toxicity pathways in target human cells, providing insight into the possibility of adverse outcomes in human health.
Keywords
URL[Source Record]
Indexed By
SCI ; EI
Language
English
Important Publications
NI Journal Papers
SUSTech Authorship
Corresponding
Funding Project
Hong Kong General Research Fund[12303321] ; National Science Foundation of China[41890852]
WOS Research Area
Engineering ; Environmental Sciences & Ecology
WOS Subject
Engineering, Environmental ; Environmental Sciences
WOS Accession No
WOS:000848402100001
Publisher
EI Accession Number
20223712702976
EI Keywords
Biological organs ; Cell death ; Electron transport properties ; High resolution transmission electron microscopy ; Metabolism ; Toxicity
ESI Classification Code
Biological Materials and Tissue Engineering:461.2 ; Health Care:461.7 ; Biology:461.9 ; Optical Devices and Systems:741.3
ESI Research Field
ENVIRONMENT/ECOLOGY
Data Source
Web of Science
Citation statistics
Cited Times [WOS]:33
Document TypeJournal Article
Identifierhttp://kc.sustech.edu.cn/handle/2SGJ60CL/395924
DepartmentSchool of Environmental Science and Engineering
Affiliation
1.Hong Kong Baptist Univ, Dept Chem, State Key Lab Environm & Biol Anal, Hong Kong, Peoples R China
2.Southern Univ Sci & Technol, Sch Environm Sci & Engn, State Environm Protect Key Lab Integrated Surface, Shenzhen, Peoples R China
3.Chinese Res Inst Environm Sci, State Key Lab Environm Criteria & Risk Assessment, Beijing, Peoples R China
4.Educ Univ Hong Kong, Dept Sci & Environm Studies, Consortium Hlth Environment Educ & Res CHEER, Hong Kong 999077, Peoples R China
First Author AffilicationSchool of Environmental Science and Engineering
Corresponding Author AffilicationSchool of Environmental Science and Engineering
Recommended Citation
GB/T 7714
Lin, Siyi,Zhang, Hongna,Wang, Chen,et al. Metabolomics Reveal Nanoplastic-Induced Mitochondrial Damage in Human Liver and Lung Cells[J]. ENVIRONMENTAL SCIENCE & TECHNOLOGY,2022.
APA
Lin, Siyi.,Zhang, Hongna.,Wang, Chen.,Su, Xiu-Li.,Song, Yuanyuan.,...&Zheng, Chunmiao.(2022).Metabolomics Reveal Nanoplastic-Induced Mitochondrial Damage in Human Liver and Lung Cells.ENVIRONMENTAL SCIENCE & TECHNOLOGY.
MLA
Lin, Siyi,et al."Metabolomics Reveal Nanoplastic-Induced Mitochondrial Damage in Human Liver and Lung Cells".ENVIRONMENTAL SCIENCE & TECHNOLOGY (2022).
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