Title | Metabolomics Reveal Nanoplastic-Induced Mitochondrial Damage in Human Liver and Lung Cells |
Author | |
Corresponding Author | Cai, Zongwei; Zheng, Chunmiao |
Publication Years | 2022-08-01
|
DOI | |
Source Title | |
ISSN | 0013-936X
|
EISSN | 1520-5851
|
Abstract | Plastic debris in the global biosphere is an increasing concern, and nanoplastic (NPs) toxicity in humans is far from being understood. Studies have indicated that NPs can affect mitochondria, but the underlying mechanisms remain unclear. The liver and lungs have important metabolic functions and are vulnerable to NP exposure. In this study, we investigated the effects of 80 nm NPs on mitochondrial functions and metabolic pathways in normal human hepatic (L02) cells and lung (BEAS-2B) cells. NP exposure did not induce mass cell death; however, transmission electron microscopy analysis showed that the NPs could enter the cells and cause mitochondrial damage, as evidenced by overproduction of mitochondrial reactive oxygen species, alterations in the mitochondrial membrane potential, and suppression of mitochondrial respiration. These alterations were observed at NP concentrations as low as 0.0125 mg/mL, which might be comparable to the environmental levels. Nontarget metabolomics confirmed that the most significantly impacted processes were mitochondrial-related. The metabolic function of L02 cells was more vulnerable to NP exposure than that of BEAS-2B cells, especially at low NP concentrations. This study identifies NP-induced mitochondrial dysfunction and metabolic toxicity pathways in target human cells, providing insight into the possibility of adverse outcomes in human health. |
Keywords | |
URL | [Source Record] |
Indexed By | |
Language | English
|
Important Publications | NI Journal Papers
|
SUSTech Authorship | Corresponding
|
Funding Project | Hong Kong General Research Fund[12303321]
; National Science Foundation of China[41890852]
|
WOS Research Area | Engineering
; Environmental Sciences & Ecology
|
WOS Subject | Engineering, Environmental
; Environmental Sciences
|
WOS Accession No | WOS:000848402100001
|
Publisher | |
EI Accession Number | 20223712702976
|
EI Keywords | Biological organs
; Cell death
; Electron transport properties
; High resolution transmission electron microscopy
; Metabolism
; Toxicity
|
ESI Classification Code | Biological Materials and Tissue Engineering:461.2
; Health Care:461.7
; Biology:461.9
; Optical Devices and Systems:741.3
|
ESI Research Field | ENVIRONMENT/ECOLOGY
|
Data Source | Web of Science
|
Citation statistics |
Cited Times [WOS]:33
|
Document Type | Journal Article |
Identifier | http://kc.sustech.edu.cn/handle/2SGJ60CL/395924 |
Department | School of Environmental Science and Engineering |
Affiliation | 1.Hong Kong Baptist Univ, Dept Chem, State Key Lab Environm & Biol Anal, Hong Kong, Peoples R China 2.Southern Univ Sci & Technol, Sch Environm Sci & Engn, State Environm Protect Key Lab Integrated Surface, Shenzhen, Peoples R China 3.Chinese Res Inst Environm Sci, State Key Lab Environm Criteria & Risk Assessment, Beijing, Peoples R China 4.Educ Univ Hong Kong, Dept Sci & Environm Studies, Consortium Hlth Environment Educ & Res CHEER, Hong Kong 999077, Peoples R China |
First Author Affilication | School of Environmental Science and Engineering |
Corresponding Author Affilication | School of Environmental Science and Engineering |
Recommended Citation GB/T 7714 |
Lin, Siyi,Zhang, Hongna,Wang, Chen,et al. Metabolomics Reveal Nanoplastic-Induced Mitochondrial Damage in Human Liver and Lung Cells[J]. ENVIRONMENTAL SCIENCE & TECHNOLOGY,2022.
|
APA |
Lin, Siyi.,Zhang, Hongna.,Wang, Chen.,Su, Xiu-Li.,Song, Yuanyuan.,...&Zheng, Chunmiao.(2022).Metabolomics Reveal Nanoplastic-Induced Mitochondrial Damage in Human Liver and Lung Cells.ENVIRONMENTAL SCIENCE & TECHNOLOGY.
|
MLA |
Lin, Siyi,et al."Metabolomics Reveal Nanoplastic-Induced Mitochondrial Damage in Human Liver and Lung Cells".ENVIRONMENTAL SCIENCE & TECHNOLOGY (2022).
|
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