中文版 | English
Title

Endobronchial Valve Treatment of Tuberculous Cavities in Patients with Multidrug-Resistant Pulmonary Tuberculosis: A Randomized Clinical Study

Author
Corresponding AuthorWang, Tao; Gong, Wenping; Wang, Zhongyuan
Publication Years
2022-08-01
DOI
Source Title
EISSN
2076-0817
Volume11Issue:8
Abstract
Background: Multidrug-resistant pulmonary tuberculosis (MDR-PTB) has become a major cause of high morbidity and mortality related to TB. Conventional drug regimens are ineffective for the treatment of MDR-PTB patients with cavities. This study aimed to evaluate the clinical efficacy and safety of one-way endobronchial valves (EBVs) for the treatment of cavities in MDR-PTB patients. Methods: MDR-PTB patients with positive sputum cultures, sputum smears, and cavities were treated with EBVs in the drainage bronchus of the pulmonary cavity between November 2013 and March 2018. The participants comprised those who had failed previous anti-tuberculosis therapy, as determined by drug susceptibility testing. Results: Thirty-five MDR-PTB patients were included, three of whom were lost during follow-up. The size of the lung cavity was reduced in all of the patients after EBV implantation, including the three lost to follow-up. In the remaining 32 patients, the sputum culture conversion (SCC) rate reached 100%, and the cavity closure rate was 68.8%. There were no significant differences in the cavity closure rate between patients aged <= 40 and >40 years, between the upper and lower lobes, or between the use and non-use of linezolid groups (p > 0.05). Interestingly, the cavity closure rate was higher in women than in men (p = 0.005). Moreover, the cavity closure rate correlated with the time to SCC (correlation coefficient, 0.8933; p < 0.0001). There were no severe adverse events in the patients treated with EBV implantation. Conclusion: EBV installation is effective and safe for the treatment of cavities in MDR-PTB patients. The efficacy of EBV treatment may not be affected by age, disease course, or the location of the lung lobe in the cavity.
Keywords
URL[Source Record]
Indexed By
Language
English
SUSTech Authorship
Corresponding
Funding Project
Beijing Municipal Science & Technology Commission["Z151100004015015","Z171100001017187"]
WOS Research Area
Microbiology
WOS Subject
Microbiology
WOS Accession No
WOS:000846564000001
Publisher
Data Source
Web of Science
Citation statistics
Cited Times [WOS]:0
Document TypeJournal Article
Identifierhttp://kc.sustech.edu.cn/handle/2SGJ60CL/395930
DepartmentThe Third People's Hospital of Shenzhen
南方科技大学第一附属医院
Affiliation
1.Peoples Liberat Army Gen Hosp, TB Prevent & Control Key Lab, Beijing Key Lab New Techn TB Diag & Treatment, Senior Dept TB,Med Ctr, Beijing 100091, Peoples R China
2.Peoples Liberat Army Gen Hosp, Dept Emergency, Med Ctr 8, Beijing 100091, Peoples R China
3.Southern Univ Sci & Technol, Shenzhen Peoples Hosp 3, Natl Clin Res Ctr Infect Dis Shenzhen, Guangdong Prov Clin Res Ctr Infect Dis TB, Shenzhen 518112, Peoples R China
Corresponding Author AffilicationThe Third People's Hospital of Shenzhen;  Shenzhen People's Hospital
Recommended Citation
GB/T 7714
An, Huiru,Liu, Xiao,Wang, Tianhao,et al. Endobronchial Valve Treatment of Tuberculous Cavities in Patients with Multidrug-Resistant Pulmonary Tuberculosis: A Randomized Clinical Study[J]. PATHOGENS,2022,11(8).
APA
An, Huiru.,Liu, Xiao.,Wang, Tianhao.,Liu, Lin.,Yan, Mengdie.,...&Wang, Zhongyuan.(2022).Endobronchial Valve Treatment of Tuberculous Cavities in Patients with Multidrug-Resistant Pulmonary Tuberculosis: A Randomized Clinical Study.PATHOGENS,11(8).
MLA
An, Huiru,et al."Endobronchial Valve Treatment of Tuberculous Cavities in Patients with Multidrug-Resistant Pulmonary Tuberculosis: A Randomized Clinical Study".PATHOGENS 11.8(2022).
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