Abnormal topological parameters in the default mode network in patients with impaired cognition undergoing maintenance hemodialysis

Cao, Chuanlong1,2; Zhang, Die3; Liu, Wanqing1,4

2022-08-18

10.3389/fneur.2022.951302

Frontiers in Neurology   Impact Factor & Quartile

1664-2295

ObjectiveThe role of the default mode network (DMN) in the cognitive impairment experienced by patients with end-stage renal disease (ESRD) undergoing maintenance hemodialysis (MHD) remains unknown. This study tested the hypothesis that the topological architecture of the DMN plays a key role in ESRD-related cognitive impairment. MethodsFor this study, 43 ERSD patients receiving MHD and 41 healthy control (HC) volunteers matched for gender, age and education underwent resting-state functional magnetic resonance imaging examinations. DMN architecture was depicted by 20 selected DMN subregions. Graph theory approaches were applied to investigate multiple topological parameters within the DMN in resting state at the global, local and edge levels. ResultsGlobally, the MHD group exhibited topological irregularities as indicated by reduced values for the clustering coeffcient (C-p), normalized C-p (gamma), world-index (sigma), and local effciency (E-loc) compared with the HC group. Locally, the MHD group showed greater nodal betweenness in the left retrosplenial cortex (RC) compared with the HC group. At the edge level, the MHD group exhibited disconnected resting-state functional connections (RSFCs) in the medial temporal lobe (MTL) subsystem including the ventral medial prefrontal cortex (VMPC)-left posterior inferior parietal lobule, VMPC-right parahippocampal cortex (PC), and right RC-left PC RSFCs. Additionally, the VMPC-right PC RSFC was positively correlated with the Digit Span Test score and E-loc, and the right RC-left PC RSFC was positively correlated with the Montreal Cognitive Assessment score and E-loc in the MHD group. ConclusionsESRD patients undergoing MHD showed local inefficiency, abnormal nodal centralities, and hypoconnectivity within the DMN, implying that the functional differentiation and local information transmission efficiency of the DMN are disturbed in ESRD. The disconnected RSFCs in the MTL subsystem likely facilitated topological reconfiguration in the DMN of ESRD patients, leading to impairments of multidomain neurocognition including memory and emotion regulation.

end-stage renal disease default mode network graph theory functional connectivity resting-state fMRI

SCI

English

Others

Neurosciences & Neurology

Clinical Neurology ; Neurosciences

WOS:000849205600001

FRONTIERS MEDIA SA

Web of Science

1.Sichuan Univ, West China Second Univ Hosp, Dept Radiol, Chengdu, Peoples R China
2.Dalian Univ, Dept Radiol, Affiliated Xinhua Hosp, Dalian, Peoples R China
3.Southern Univ Sci & Technol, Shenzhen Peoples Hosp 3, Affiliated Hosp 2, Natl Clin Res Ctr Infect Dis,Sch Med ,Dept Radiol, Shenzhen, Peoples R China
4.Sichuan Univ, Key Lab Birth Defects & Related Dis Women & Childr, Minist Educ, Chengdu, Peoples R China

Cao, Chuanlong,Zhang, Die,Liu, Wanqing. Abnormal topological parameters in the default mode network in patients with impaired cognition undergoing maintenance hemodialysis[J]. Frontiers in Neurology,2022,13.

Cao, Chuanlong,Zhang, Die,&Liu, Wanqing.(2022).Abnormal topological parameters in the default mode network in patients with impaired cognition undergoing maintenance hemodialysis.Frontiers in Neurology,13.

Cao, Chuanlong,et al."Abnormal topological parameters in the default mode network in patients with impaired cognition undergoing maintenance hemodialysis".Frontiers in Neurology 13(2022).