| Title | Gut immune cells-A novel therapeutical target for cardiovascular disease? |
| Author | |
| Corresponding Author | Kahles, Florian |
| Publication Years | 2022-08-15
|
| DOI | |
| Source Title | |
| ISSN | 2297-055X
|
| Volume | 9 |
| Abstract | Despite scientific and clinical advances during the last 50 years cardiovascular disease continues to be the main cause of death worldwide. Especially patients with diabetes display a massive increased cardiovascular risk compared to patients without diabetes. Over the last two decades we have learned that cardiometabolic and cardiovascular diseases are driven by inflammation. Despite the fact that the gastrointestinal tract is one of the largest leukocyte reservoirs of our bodies, the relevance of gut immune cells for cardiovascular disease is largely unknown. First experimental evidence suggests an important relevance of immune cells in the intestinal tract for the development of metabolic and cardiovascular disease in mice. Mice specifically lacking gut immune cells are protected against obesity, diabetes, hypertension and atherosclerosis. Importantly antibody mediated inhibition of leukocyte homing into the gut showed similar protective metabolic and cardiovascular effects. Targeting gut immune cells might open novel therapeutic approaches for the treatment of cardiometabolic and cardiovascular diseases. |
| Keywords | |
| URL | [Source Record] |
| Indexed By | |
| Language | English
|
| SUSTech Authorship | Others
|
| Funding Project | European Research Area Network on Cardiovascular Diseases (BMBF)["JTC-2019","MyPenPath-01KL2004"]
; European Foundation for the Study of Diabetes (EFSD)/Novo Nordisk Foundation[NNF2OSA0066111]
; Deutsche Forschungsgemeinschaft[SFB TRR 219 M-03]
; Deutsche Forschungsgemeinschaft (German Research Foundation)["TRR 219","322900939"]
; NWOZonMw Veni[91619053]
|
| WOS Research Area | Cardiovascular System & Cardiology
|
| WOS Subject | Cardiac & Cardiovascular Systems
|
| WOS Accession No | WOS:000848384100001
|
| Publisher | |
| Data Source | Web of Science
|
| Citation statistics |
Cited Times [WOS]:0
|
| Document Type | Journal Article |
| Identifier | http://kc.sustech.edu.cn/handle/2SGJ60CL/395965 |
| Department | School of Medicine |
| Affiliation | 1.Univ Hosp Aachen, Dept Cardiol Angiol & Intens Care Med, Aachen, Germany 2.Univ Hosp Aachen, Interdisciplinary Ctr Clin Res IZKF, Aachen, Germany 3.Univ Hosp Aachen, Inst Mol Cardiovasc Res IMCAR, Aachen, Germany 4.Maastricht Univ, Cardiovasc Res Inst Maastricht CARIM, Dept Pathol, Med Ctr, Maastricht, Netherlands 5.Ludwig Maximilians Univ Munchen, Inst Cardiovasc Prevent IPEK, Munich, Germany 6.Univ Hosp Aachen, Dept Pneumol & Intens Care Med, Aachen, Germany 7.Southern Univ Sci & Technol, Sch Med, Shenzhen, Peoples R China 8.Univ Hosp Munster, Dept Cardiol Coronary & Peripheral Vasc Dis Heart, Munster, Germany 9.Icahn Sch Med Mt Sinai, Cardiovasc Res Inst, New York, NY USA |
| Recommended Citation GB/T 7714 |
Ganesh, Naresh,van Der Vorst, Emiel P. C.,Spiesshofer, Jens,et al. Gut immune cells-A novel therapeutical target for cardiovascular disease?[J]. Frontiers in Cardiovascular Medicine,2022,9.
|
| APA |
Ganesh, Naresh.,van Der Vorst, Emiel P. C..,Spiesshofer, Jens.,He, Shun.,Burgmaier, Mathias.,...&Kahles, Florian.(2022).Gut immune cells-A novel therapeutical target for cardiovascular disease?.Frontiers in Cardiovascular Medicine,9.
|
| MLA |
Ganesh, Naresh,et al."Gut immune cells-A novel therapeutical target for cardiovascular disease?".Frontiers in Cardiovascular Medicine 9(2022).
|
| Files in This Item: | There are no files associated with this item. | |||||
Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.
Edit Comment