High expression of HIV-1 matrix protein p17 in both lymphoma and lymph node tissues of AIDS patients

Feng, Yanling1; Wang, Zhenyan2; Zeng, Dong1; Song, Shu1; Yang, Yuexiang1; Wang, Ao1; Xu, Jingjing1; Guo, Wenjuan1; Wu, Minmin1; Shi, Yuhan1; Zheng, Ye1; Li, Duoduo1; Zhang, Renfang2; Lu, Hongzhou3

2022-09-01

10.1016/j.prp.2022.154061

PATHOLOGY RESEARCH AND PRACTICE   Impact Factor & Quartile

0344-0338

1618-0631

Background: HIV-1 matrix protein p17 was found to be associated with lymphoma development in vitro. This study aimed to elucidate the pathogenetic roles of HIV-1 p17 in AIDS-related lymphoma.Methods: Expression of HIV-1 proteins p17, p24, nef and tat were evaluated in tumor tissue samples from 60 lymphoma patients and lymph node samples from 23 non-lymphoma patients with HIV-1 infection by immu-nohistochemistry. Microvascular density (MVD) determined by CD34 were also assessed in tumor tissues. Clinicopathological data of AIDS patients with lymphoma were collected retrospectively.Results: The subtypes of lymphoma among sixty AIDS patients were diffuse large B-cell lymphoma (32 cases), Burkitt lymphoma (23 cases), Hodgkin's lymphoma (4 cases), and plasmablastic lymphoma (1 case). The expression rate of HIV-1 p17 in lymphoma and non-lymphoma group was 63 % (38/60) and 61 % (14/29) respectively, with no significant difference (p = 0.835). The positive expression rate of p17 in both groups was significantly higher than that of p24, nef and tat (p < 0.05). The expression of p17 was associated with a higher MVD in the lymphoma group (p < 0.05). There were no significant differences in the 2-years overall survival between p17 positive and negative group (61 % vs. 50 %, p = 0.525).Conclusion: The common expression of HIV-1 matrix protein p17 in both lymphoma and lymph node tissues of AIDS patients and the association between p17 expression and the higher MVD suggest that the accumulation and persistence of p17 in tissues may play a role in lymphoma development.

AIDS HIV P17 Lymphoma Expression

SCI

English

Others

Clinical Science and Technology Innovation project of Shanghai Shenkang Hospital Development Center[SHDC12019X36] ; Shanghai Municipal Health Commission Scientific Research Project[201940225] ; Shanghai Major Projects on Infectious Diseases[shslczdzk01102] ; Three -Year Action Plan for Strengthening Public Health System in Shanghai[GWV-10.1-XK02]

Pathology

Pathology

WOS:000850146200002

ELSEVIER GMBH

CLINICAL MEDICINE

Web of Science

1.Fudan Univ, Shanghai Publ Hlth Clin Ctr, Dept Pathol, 2901 Caolang Rd, Shanghai 201508, Peoples R China
2.Fudan Univ, Shanghai Publ Hlth Clin Ctr, Dept Infect & Immun, 2901 Caolang Rd, Shanghai 201508, Peoples R China
3.Southern Univ Sci & Technol, Shenzhen Key Lab Pathogen & Immun, Natl Clin Res Ctr Infect Dis,Hosp Affiliated 2, State Key Discipline Infect Dis,Peoples Hosp Shen, Shenzhen 518112, Guangdong, Peoples R China

Feng, Yanling,Wang, Zhenyan,Zeng, Dong,et al. High expression of HIV-1 matrix protein p17 in both lymphoma and lymph node tissues of AIDS patients[J]. PATHOLOGY RESEARCH AND PRACTICE,2022,237.

Feng, Yanling.,Wang, Zhenyan.,Zeng, Dong.,Song, Shu.,Yang, Yuexiang.,...&Lu, Hongzhou.(2022).High expression of HIV-1 matrix protein p17 in both lymphoma and lymph node tissues of AIDS patients.PATHOLOGY RESEARCH AND PRACTICE,237.

Feng, Yanling,et al."High expression of HIV-1 matrix protein p17 in both lymphoma and lymph node tissues of AIDS patients".PATHOLOGY RESEARCH AND PRACTICE 237(2022).