Title | Endomembrane remodeling in SARS-CoV-2 infection |
Author | |
Corresponding Author | Zhang Hong |
Publication Years | 2022-05-17
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DOI | |
Source Title | |
Abstract | During severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, the viral proteins intimately interact with host factors to remodel the endomembrane system at various steps of the viral lifecycle. The entry of SARS-CoV-2 can be mediated by endocytosis-mediated internalization. Virus-containing endosomes then fuse with lysosomes, in which the viral S protein is cleaved to trigger membrane fusion. Double-membrane vesicles generated from the ER serve as platforms for viral replication and transcription. Virions are assembled at the ER–Golgi intermediate compartment and released through the secretory pathway and/or lysosome-mediated exocytosis. In this review, we will focus on how SARS CoV-2 viral proteins collaborate with host factors to remodel the endomembrane system for viral entry, replication, assembly and egress. We will also describe how viral proteins hijack the host cell surveillance system—the autophagic degradation pathway—to evade destruction and benefit virus production. Finally, potential antiviral therapies targeting the host cell endomembrane system will be discussed. |
Keywords | |
Indexed By | |
Language | English
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SUSTech Authorship | Others
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Data Source | 人工提交
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Citation statistics |
Cited Times [WOS]:0
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Document Type | Journal Article |
Identifier | http://kc.sustech.edu.cn/handle/2SGJ60CL/401337 |
Department | School of Life Sciences 生命科学学院_生物系 |
Affiliation | 1.National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, 2.Department of Biology, School of Life Sciences, Southern University of Science and Technology 3.College of Life Sciences, University of Chinese Academy of Sciences |
Recommended Citation GB/T 7714 |
Chen Di,Zhao Yan G.,Zhang Hong. Endomembrane remodeling in SARS-CoV-2 infection[J]. Cell Insight,2022.
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APA |
Chen Di,Zhao Yan G.,&Zhang Hong.(2022).Endomembrane remodeling in SARS-CoV-2 infection.Cell Insight.
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MLA |
Chen Di,et al."Endomembrane remodeling in SARS-CoV-2 infection".Cell Insight (2022).
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