Nanoradiosensitizer with good tissue penetration and enhances oral cancer radiotherapeutic effect
|Corresponding Author||Zhang，Lu; Lam，Kit S.|
Low dose non-toxic disulfide cross-linked micelle (DCM) encapsulated paclitaxel (PTX) was found to be highly efficacious as a radiosensitizer against oral cancer preclinical model. Intensity-modulated radiation therapy was locally administered for three consecutive days 24 h after intravascular injection of DCM-[PTX] at 5 mg/kg PTX. DCM-[PTX] NPs combined with conventional radiotherapy (2 Gy) resulted in a 1.7-fold improvement in therapeutic efficacy compared to conventional PTX plus radiotherapy. Interestingly, we found that radiotherapy can decrease tight junctions and increase the accumulation of DCM-[PTX] in tumor sites. Stereotactic body radiotherapy (SBRT) given at 6 Gy was used to further investigate the synergistic anti-tumor effect. Tumor tissues were collected to analyze the relationship between the time interval after SBRT and the biodistribution of the nanomaterials. Compared to combination DCM-[PTX] with conventional radiation dose, combination DCM-PTX with SBRT was found to be more efficacious in inhibiting tumor growth.
NIH of United States Grants["R01CA115483","U01CA198880","R01CA247683"] ; Hunan Provincial Natural Science Foundation of China[2022JJ30933]
|WOS Research Area|
Engineering ; Materials Science
Engineering, Biomedical ; Materials Science, Biomaterials
|WOS Accession No|
|EI Accession Number|
Diseases ; Dosimetry ; Micelles ; Sulfur compounds ; Tumors
|ESI Classification Code|
Biological Materials and Tissue Engineering:461.2 ; Medicine and Pharmacology:461.6 ; Radioactive Material Applications:622.3 ; Colloid Chemistry:801.3 ; Radiation Measurements:944.8
|ESI Research Field|
Cited Times [WOS]:1
|Document Type||Journal Article|
|Department||Department of Biomedical Engineering|
1.Department of Biochemistry and Molecular Medicine,UC Davis Comprehensive Cancer Center,University of California Davis,Sacramento,United States
2.Department of Oncology,National Clinical Research Center for Geriatric Disorders,Xiangya Hospital,Central South University,Changsha,Hunan,China
3.Department of Biomedical Engineering,Southern University of Science and Technology,Shenzhen,Guangdong,China
4.Department of Radiation Oncology,School of Medicine,University of California Davis,Sacramento,United States
5.Department of Neurosurgery,Xiangya Hospital,Central South University,Changsha,China
6.Division of Hematology and Oncology,Department of Internal Medicine,School of Medicine,University of California Davis,Sacramento,United States
|Corresponding Author Affilication||Department of Biomedical Engineering|
Jing，Di,Jiang，Nian,Wang，Fengyi,et al. Nanoradiosensitizer with good tissue penetration and enhances oral cancer radiotherapeutic effect[J]. BIOMATERIALS,2022,289.
Jing，Di.,Jiang，Nian.,Wang，Fengyi.,Mao，Chunping.,Han，Shujun.,...&Lam，Kit S..(2022).Nanoradiosensitizer with good tissue penetration and enhances oral cancer radiotherapeutic effect.BIOMATERIALS,289.
Jing，Di,et al."Nanoradiosensitizer with good tissue penetration and enhances oral cancer radiotherapeutic effect".BIOMATERIALS 289(2022).
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