中文版 | English
Title

Neisseria species as pathobionts in bronchiectasis

Author
Corresponding AuthorChotirmall,Sanjay H.
Publication Years
2022-09-14
DOI
Source Title
ISSN
1931-3128
EISSN
1934-6069
Volume30Issue:9Pages:1311-1327.e8
Abstract

Neisseria species are frequently identified in the bronchiectasis microbiome, but they are regarded as respiratory commensals. Using a combination of human cohorts, next-generation sequencing, systems biology, and animal models, we show that bronchiectasis bacteriomes defined by the presence of Neisseria spp. associate with poor clinical outcomes, including exacerbations. Neisseria subflava cultivated from bronchiectasis patients promotes the loss of epithelial integrity and inflammation in primary epithelial cells. In vivo animal models of Neisseria subflava infection and metabolipidome analysis highlight immunoinflammatory functional gene clusters and provide evidence for pulmonary inflammation. The murine metabolipidomic data were validated with human Neisseria-dominant bronchiectasis samples and compared with disease in which Pseudomonas-, an established bronchiectasis pathogen, is dominant. Metagenomic surveillance of Neisseria across various respiratory disorders reveals broader importance, and the assessment of the home environment in bronchiectasis implies potential environmental sources of exposure. Thus, we identify Neisseria species as pathobionts in bronchiectasis, allowing for improved risk stratification in this high-risk group.

Keywords
URL[Source Record]
Indexed By
Language
English
Important Publications
NI Journal Papers
SUSTech Authorship
First
Funding Project
Natural Science Foundation of Guangdong Province[2021A1515010004] ; National Natural Science Foundation of China[81900071] ; National Medical Research Council[MOH-000141] ; National Medical Research Council[MOH-000710]
WOS Research Area
Microbiology ; Parasitology ; Virology
WOS Subject
Microbiology ; Parasitology ; Virology
WOS Accession No
WOS:000889279600003
Publisher
Scopus EID
2-s2.0-85137627517
Data Source
Scopus
Citation statistics
Cited Times [WOS]:9
Document TypeJournal Article
Identifierhttp://kc.sustech.edu.cn/handle/2SGJ60CL/401616
DepartmentDepartment of Pharmacology
南方科技大学医学院
Affiliation
1.Department of Pharmacology,School of Medicine,Southern University of Science and Technology,Shenzhen,China
2.Shenzhen Institutes of Advanced Technology,Chinese Academy of Sciences,Shenzhen,China
3.Lee Kong Chian School of Medicine,Nanyang Technological University,Singapore,Singapore
4.Biochemical Genetics Laboratory,Department of Biochemistry,St. James's Hospital,Dublin,Ireland
5.Clinical Biochemistry Unit,School of Medicine,Trinity College Dublin,Dublin,Ireland
6.School of Civil and Environmental Engineering,Nanyang Technological University,Singapore,Singapore
7.College of Pharmaceutical Sciences,Zhejiang University,Hangzhou,310058,China
8.University of Dundee,Ninewells Hospital,Medical School,Dundee,United Kingdom
9.Department of Otolaryngology,Infectious Disease Translational Research Programme,Yong Loo Lin School of Medicine,National University of Singapore,Singapore,Singapore
10.Department of Respiratory and Critical Care Medicine,Singapore General Hospital,Singapore,Singapore
11.Department of Respiratory and Critical Care Medicine,Tan Tock Seng Hospital,Singapore,Singapore
12.Department of Respiratory and Critical Care Medicine,Changi General Hospital,Singapore,Singapore
13.Universiti Kebangsaan Malaysia,Kuala Lumpur,Malaysia
14.Department of Respiratory Medicine and Critical Care,Peking University Shenzhen Hospital,Shenzhen,China
15.Priority Research Centre for Healthy Lungs,Hunter Medical Research Institute,School of Medicine and Public Health,University of Newcastle,Newcastle,Australia
16.Department of Respiratory and Sleep Medicine,John Hunter Hospital,New Lambton Heights,Australia
17.Woolcock Institute of Medical Research,University of Sydney,Sydney,Australia
18.School of Life Sciences,University of Technology Sydney,Sydney,Australia
19.Singapore Centre for Environmental Life Sciences Engineering (SCELSE),Nanyang Technological University,Singapore,Singapore
20.School of Biological Sciences,Nanyang Technological University,Singapore,Singapore
21.Department of Environmental Science and Engineering,Fudan University,Shanghai,200433,China
First Author AffilicationDepartment of Pharmacology;  School of Medicine
First Author's First AffilicationDepartment of Pharmacology;  School of Medicine
Recommended Citation
GB/T 7714
Li,Liang,Mac Aogáin,Micheál,Xu,Tengfei,et al. Neisseria species as pathobionts in bronchiectasis[J]. Cell Host & Microbe,2022,30(9):1311-1327.e8.
APA
Li,Liang.,Mac Aogáin,Micheál.,Xu,Tengfei.,Jaggi,Tavleen Kaur.,Chan,Louisa L.Y..,...&Chotirmall,Sanjay H..(2022).Neisseria species as pathobionts in bronchiectasis.Cell Host & Microbe,30(9),1311-1327.e8.
MLA
Li,Liang,et al."Neisseria species as pathobionts in bronchiectasis".Cell Host & Microbe 30.9(2022):1311-1327.e8.
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