中文版 | English
Title

补体系统在葡萄膜炎发病机制中的作用

Alternative Title
Role of complement system in the pathogenesis of uveitis
Author
Publication Years
2022
DOI
Source Title
ISSN
1672-5123
Volume22Issue:8Pages:1293-1297
Abstract
葡萄膜炎是一组累及虹膜、睫状体、脉络膜、玻璃体、视网膜及视网膜血管的炎症性疾病,可造成视力减退甚至视力丧失.葡萄膜炎的发病机制复杂多样,如感染、自身免疫、创伤及理化损伤、免疫遗传机制等.近年有研究表明,补体系统的激活是葡萄膜炎的发病机制之一,多种补体蛋白包括CFH、CFB、CFI、MAC、CD59等通过严密的机制调控补体系统介导的宿主组织损伤,研究发现补体蛋白在基因层面和生物学功能等方面参与了葡萄膜炎的发生发展.另外C2、C3、C4、C5等补体成分在拷贝数变异、基因多态性及调节T细胞反应介导自身免疫发展等方面影响葡萄膜炎的发病机制.因此,补体抑制疗法和相关基因疗法为葡萄膜炎的治疗提供了新的思路及作用靶点.
Keywords
URL[Source Record]
Language
Chinese
SUSTech Authorship
Others
Data Source
WanFang
WanFangID
mzgjykzz202208011
Citation statistics
Cited Times [WOS]:0
Document TypeJournal Article
Identifierhttp://kc.sustech.edu.cn/handle/2SGJ60CL/401640
DepartmentShenzhen People's Hospital
Affiliation
1.150000 中国黑龙江省哈尔滨市,哈尔滨医科大学附属第一医院眼科医院
2.518020 中国广东省深圳市人民医院暨南大学第二临床医学院 南方科技大学第一附属医院
Recommended Citation
GB/T 7714
熊慧,杨明明,于旭辉. 补体系统在葡萄膜炎发病机制中的作用[J]. International Journal of Ophthalmology,2022,22(8):1293-1297.
APA
熊慧,杨明明,&于旭辉.(2022).补体系统在葡萄膜炎发病机制中的作用.International Journal of Ophthalmology,22(8),1293-1297.
MLA
熊慧,et al."补体系统在葡萄膜炎发病机制中的作用".International Journal of Ophthalmology 22.8(2022):1293-1297.
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