Photodynamic Hydrogen-Bonded Biohybrid Framework: A Photobiocatalytic Cascade Nanoreactor for Accelerating Diabetic Wound Therapy
|Corresponding Author||Wang，Jigang; Huang，Siming; Chen，Guosheng|
|Joint first author||Huang，Wei; Yuan，Haitao|
A diabetic wound causes thousands of infections or deaths around the world each year, and its healing remains a critical challenge because of the ease of multidrug-resistant (MDR) bacterial infection, as well as the intrinsic hyperglycemic and hypoxia microenvironment that inhibits the therapeutic efficiency. Herein, we pioneer the design of a photobiocatalytic cascade nanoreactor via spatially organizing the biocatalysts and photocatalysts utilizing a hydrogen-bonded organic framework (HOF) scaffold for diabetic wound therapy. The HOF scaffold enables it to disperse and stabilize the host cargos, and the formed long-range-ordered mesochannels also facilitate the mass transfer that enhances the cascade activity. This integrated HOF nanoreactor allows the continuous conversion of overexpressed glucose and H2O2 into toxic reactive oxygen species by the photobiocatalytic cascade. As a result, it readily reverses the microenvironment of the diabetes wound and exhibits an extraordinary capacity for wound healing through synergistic photodynamic therapy. This work describes the first example of constructing an all-in-one HOF bioreactor for antimicrobial diabetes wound treatment and showcases the promise of combined biocatalysis and photocatalysis achieved by using an HOF scaffold in biomedicine applications.
|WOS Accession No|
|EI Accession Number|
Catalysis ; Enzyme Immobilization ; Hydrogen Bonds ; Mass Transfer ; Nanoreactors ; Photodynamic Therapy ; Scaffolds
Cited Times [WOS]:14
|Document Type||Journal Article|
|Department||Cryo-Electron Microscopy Center|
1.School of Chemical Engineering and Technology,Sun Yat-sen University,Zhuhai,519082,China
2.MOE Key Laboratory of Bioinorganic and Synthetic Chemistry,School of Chemistry,Sun Yat-sen University,Guangzhou,510275,China
3.Department of Geriatric Medicine,Shenzhen People's Hospital,The Second Clinical Medical College,Jinan University,Shenzhen,518020,China
4.Guangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target and Clinical Pharmacology,the NMPA and State Key Laboratory of Respiratory Disease,School of Pharmaceutical Sciences and the Fifth Affiliated Hospital,Guangzhou Medical University,Guangzhou,511436,China
5.Cryo-EM Center,Southern University of Science and Technology,Shenzhen,518055,China
Huang，Wei,Yuan，Haitao,Yang，Huangsheng,et al. Photodynamic Hydrogen-Bonded Biohybrid Framework: A Photobiocatalytic Cascade Nanoreactor for Accelerating Diabetic Wound Therapy[J]. JACS Au,2022.
Huang，Wei.,Yuan，Haitao.,Yang，Huangsheng.,Tong，Linjing.,Gao，Rui.,...&Ouyang，Gangfeng.(2022).Photodynamic Hydrogen-Bonded Biohybrid Framework: A Photobiocatalytic Cascade Nanoreactor for Accelerating Diabetic Wound Therapy.JACS Au.
Huang，Wei,et al."Photodynamic Hydrogen-Bonded Biohybrid Framework: A Photobiocatalytic Cascade Nanoreactor for Accelerating Diabetic Wound Therapy".JACS Au (2022).
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