中文版 | English
Title

A novel clustered SPIO nanoplatform with enhanced magnetic resonance T2 relaxation rate for micro-tumor detection and photothermal synergistic therapy

Author
Corresponding AuthorZou,Liming; Wang,Zhongling
Publication Years
2020-08-01
DOI
Source Title
ISSN
1998-0124
EISSN
1998-0000
Volume13Issue:8Pages:2216-2225
Abstract
Construction of micro tumor sensitive theranostic nanoagents that can increase the accuracy of imaging diagnosis and boost the therapeutic efficacy has been demonstrated for a promising approach for diagnosis and treatment of cancer. Herein, we reported a novel super-paramagnetic iron oxide (SPIO) based nanoplatform that possess significantly enhanced magnetic resonance property and photothermal effect for tumor theranostic purpose. This polyethylene glycol with four phenylboronic acid (PEG-B4)/CNTs@porphyrin (ph)/SPIO (BCPS) nanoplatform was simply prepared via integrated SPIO, ph, and a novel dendrimer with PEG liner and four PBA groups (PEG-B4) on the surface of carbon nanotubes (CNTs). Subsequently, a significant T2 relaxation rate enhanced can be achieved by the reduced accessibility of water to SPIO clustering. Moreover, the synergetic enhanced photothermal from BCPS nanoplatform contributed to better photothermal effect for cancer therapy. Furthermore, the targeting ability to sialic acid overexpressed tumor was further introduced from phenylboronic acid from PEG-B4. We showed that BCPS nanoplatform could not only selectively identify solid tumors and detect micro-sized metastatic tumor (1 mm) in the liver, but also effectively ablate tumors in a xenograft model, thereby achieving a complete cure rate of 100% at low laser dose. Our results highlight the potential of BCPS nanoplatform for accurate micro-tumor diagnosis and effective tumor therapy. [Figure not available: see fulltext.].
Keywords
URL[Source Record]
Indexed By
SCI ; EI
Language
English
SUSTech Authorship
Others
WOS Accession No
WOS:000543638700004
EI Accession Number
20202608872507
EI Keywords
Diseases ; Carbon nanotubes ; Tumors ; Magnetic resonance ; Diagnosis ; Organic acids
ESI Classification Code
Biological Materials and Tissue Engineering:461.2 ; Medicine and Pharmacology:461.6 ; Magnetism: Basic Concepts and Phenomena:701.2 ; Nanotechnology:761 ; Organic Compounds:804.1 ; Inorganic Compounds:804.2 ; Crystalline Solids:933.1
Scopus EID
2-s2.0-85087062164
Data Source
Scopus
Citation statistics
Cited Times [WOS]:13
Document TypeJournal Article
Identifierhttp://kc.sustech.edu.cn/handle/2SGJ60CL/401714
DepartmentDepartment of Materials Science and Engineering
Affiliation
1.Department of Radiology,Shanghai General Hospital,School of Medicine,Shanghai Jiaotong University,Shanghai,200080,China
2.State Key Laboratory for Modification of Chemical Fibers and Polymer Materials,College of Materials Science and Engineering,Donghua University,Shanghai,201620,China
3.ARC Centre of Excellence in Convergent Bio-Nano Science and Technology,Monash Institute of Pharmaceutical Sciences,Monash University,Parkville,381 Royal Parade,3052,Australia
4.Department of Radiology,The First Affiliated Hospital of Soochow University,Suzhou,215006,China
5.Department of Gastroenterology,Nanjing Drum Tower Hospital,Affiliated Hospital of Nanjing University Medical School,Nanjing,210029,China
6.Department of Materials Science and Engineering,Southern University of Science and Technology,Shenzhen,518055,China
Recommended Citation
GB/T 7714
Lu,Hongwei,Xu,Yongjing,Qiao,Ruirui,et al. A novel clustered SPIO nanoplatform with enhanced magnetic resonance T2 relaxation rate for micro-tumor detection and photothermal synergistic therapy[J]. Nano Research,2020,13(8):2216-2225.
APA
Lu,Hongwei.,Xu,Yongjing.,Qiao,Ruirui.,Lu,Ziwei.,Wang,Pin.,...&Wang,Zhongling.(2020).A novel clustered SPIO nanoplatform with enhanced magnetic resonance T2 relaxation rate for micro-tumor detection and photothermal synergistic therapy.Nano Research,13(8),2216-2225.
MLA
Lu,Hongwei,et al."A novel clustered SPIO nanoplatform with enhanced magnetic resonance T2 relaxation rate for micro-tumor detection and photothermal synergistic therapy".Nano Research 13.8(2020):2216-2225.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Export to Excel
Export to Csv
Altmetrics Score
Google Scholar
Similar articles in Google Scholar
[Lu,Hongwei]'s Articles
[Xu,Yongjing]'s Articles
[Qiao,Ruirui]'s Articles
Baidu Scholar
Similar articles in Baidu Scholar
[Lu,Hongwei]'s Articles
[Xu,Yongjing]'s Articles
[Qiao,Ruirui]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Lu,Hongwei]'s Articles
[Xu,Yongjing]'s Articles
[Qiao,Ruirui]'s Articles
Terms of Use
No data!
Social Bookmark/Share
No comment.

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.