A novel clustered SPIO nanoplatform with enhanced magnetic resonance T2 relaxation rate for micro-tumor detection and photothermal synergistic therapy
|Corresponding Author||Zou，Liming; Wang，Zhongling|
Construction of micro tumor sensitive theranostic nanoagents that can increase the accuracy of imaging diagnosis and boost the therapeutic efficacy has been demonstrated for a promising approach for diagnosis and treatment of cancer. Herein, we reported a novel super-paramagnetic iron oxide (SPIO) based nanoplatform that possess significantly enhanced magnetic resonance property and photothermal effect for tumor theranostic purpose. This polyethylene glycol with four phenylboronic acid (PEG-B4)/CNTs@porphyrin (ph)/SPIO (BCPS) nanoplatform was simply prepared via integrated SPIO, ph, and a novel dendrimer with PEG liner and four PBA groups (PEG-B4) on the surface of carbon nanotubes (CNTs). Subsequently, a significant T2 relaxation rate enhanced can be achieved by the reduced accessibility of water to SPIO clustering. Moreover, the synergetic enhanced photothermal from BCPS nanoplatform contributed to better photothermal effect for cancer therapy. Furthermore, the targeting ability to sialic acid overexpressed tumor was further introduced from phenylboronic acid from PEG-B4. We showed that BCPS nanoplatform could not only selectively identify solid tumors and detect micro-sized metastatic tumor (1 mm) in the liver, but also effectively ablate tumors in a xenograft model, thereby achieving a complete cure rate of 100% at low laser dose. Our results highlight the potential of BCPS nanoplatform for accurate micro-tumor diagnosis and effective tumor therapy. [Figure not available: see fulltext.].
|WOS Accession No|
|EI Accession Number|
Diseases ; Carbon nanotubes ; Tumors ; Magnetic resonance ; Diagnosis ; Organic acids
|ESI Classification Code|
Biological Materials and Tissue Engineering:461.2 ; Medicine and Pharmacology:461.6 ; Magnetism: Basic Concepts and Phenomena:701.2 ; Nanotechnology:761 ; Organic Compounds:804.1 ; Inorganic Compounds:804.2 ; Crystalline Solids:933.1
Cited Times [WOS]:13
|Document Type||Journal Article|
|Department||Department of Materials Science and Engineering|
1.Department of Radiology,Shanghai General Hospital,School of Medicine,Shanghai Jiaotong University,Shanghai,200080,China
2.State Key Laboratory for Modification of Chemical Fibers and Polymer Materials,College of Materials Science and Engineering,Donghua University,Shanghai,201620,China
3.ARC Centre of Excellence in Convergent Bio-Nano Science and Technology,Monash Institute of Pharmaceutical Sciences,Monash University,Parkville,381 Royal Parade,3052,Australia
4.Department of Radiology,The First Affiliated Hospital of Soochow University,Suzhou,215006,China
5.Department of Gastroenterology,Nanjing Drum Tower Hospital,Affiliated Hospital of Nanjing University Medical School,Nanjing,210029,China
6.Department of Materials Science and Engineering,Southern University of Science and Technology,Shenzhen,518055,China
Lu，Hongwei,Xu，Yongjing,Qiao，Ruirui,et al. A novel clustered SPIO nanoplatform with enhanced magnetic resonance T2 relaxation rate for micro-tumor detection and photothermal synergistic therapy[J]. Nano Research,2020,13(8):2216-2225.
Lu，Hongwei.,Xu，Yongjing.,Qiao，Ruirui.,Lu，Ziwei.,Wang，Pin.,...&Wang，Zhongling.(2020).A novel clustered SPIO nanoplatform with enhanced magnetic resonance T2 relaxation rate for micro-tumor detection and photothermal synergistic therapy.Nano Research,13(8),2216-2225.
Lu，Hongwei,et al."A novel clustered SPIO nanoplatform with enhanced magnetic resonance T2 relaxation rate for micro-tumor detection and photothermal synergistic therapy".Nano Research 13.8(2020):2216-2225.
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