中文版 | English
Title

血清sICAM1、TNFR1、miRNA155检测对早期1型糖尿病肾病诊断的价值研究

Alternative Title
The Value of Serum sICAM1,TNFR1 and miRNA155 Detection in the Diagnosis of Early Type 1 Diabetic Nephropathy
Author
Publication Years
2022
DOI
Source Title
ISSN
2095-4646
Volume36Issue:3Pages:236-240
Abstract
目的 探讨血清可溶性细胞间黏附因子1(sICAM1)、肿瘤坏死因子受体1(TNFR1)、微小RNA(miR-NA)-155在1型糖尿病肾病早期诊断中的价值.方法 选取我院收治的1型糖尿病(T1DM)患者101例,根据尿白蛋白排泄率(UAER)分为糖尿病(DM)组和早期糖尿病肾病(DKD)组,采用Logistic回归分析DKD的可能影响因素;建立受试者工作特征曲线(ROC),计算曲线下面积(AUC),分析血清sICAM1、TNFR1、miRNA155对早期DKD的诊断价值.结果 101例T1DM患者发生DKD 37例,发生率为36.63%.早期DKD组血肌酐(Scr)、血尿素氮(BUN)、超敏C反应蛋白(hs-CRP)、sICAM1、TNFR1、miRNA155高于DM组,估算肾小球滤过率(eGFR)低于 DM 组(P<0.05).Logistic 结果显示,hsCRP(OR =2.140,P = 0.023)、eGFR(OR = 0.425,P =0.009)、sICAM1(OR =4.187,P= 0.001)、TNFR1(OR =4.697,P<0.001)、miRNA155(OR = 3.832,P<0.001)均是发生DKD的影响因素.ROC结果显示,血清sICAM1、TNFR1、miRNA155单独及联合诊断早期DKD的AUC 分别为 0.762、0.749、0.756、0.835.结论 DKD 患者血清 sICAM1、TNFR1、miRNA155 水平高于单纯 DM 患者,三者联合检测对早期DKD具有较高诊断价值.
Keywords
URL[Source Record]
Language
Chinese
SUSTech Authorship
Others
Funding Project
深圳市南山区技术研发 ; 创意设计项目
Data Source
WanFang
WanFangID
xnyxyxb202203014
Citation statistics
Cited Times [WOS]:0
Document TypeJournal Article
Identifierhttp://kc.sustech.edu.cn/handle/2SGJ60CL/401894
DepartmentSouthern University of Science and Technology Hospital
Affiliation
南方科技大学医院重症医学科,广东深圳518000
Recommended Citation
GB/T 7714
熊敏,潘勇军,苗新宇. 血清sICAM1、TNFR1、miRNA155检测对早期1型糖尿病肾病诊断的价值研究[J]. 湖北科技学院学报(医学版),2022,36(3):236-240.
APA
熊敏,潘勇军,&苗新宇.(2022).血清sICAM1、TNFR1、miRNA155检测对早期1型糖尿病肾病诊断的价值研究.湖北科技学院学报(医学版),36(3),236-240.
MLA
熊敏,et al."血清sICAM1、TNFR1、miRNA155检测对早期1型糖尿病肾病诊断的价值研究".湖北科技学院学报(医学版) 36.3(2022):236-240.
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