| Title | 介质研磨法制备他达拉非纳米混悬液研究 |
| Alternative Title | Preparation of tadalafil nanosuspension by wet media milling
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| Author | |
| Publication Years | 2022
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| DOI | |
| Source Title | |
| ISSN | 1001-5213
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| Volume | 42Issue:11Pages:1121-1125,1137 |
| Abstract | 目的:采用介质研磨法制备他达拉非纳米混悬液,以提高他达拉非的溶出度和生物利用度.方法:以粒径、多分散指数(PDI)、Zeta电位和物理稳定性为评价指标,优化处方和工艺参数;采用扫描电镜(SEM)、X-射线粉末衍射法(XRPD)、差示扫描量热法(DSC)对样品进行表征,HPLC法测定他达拉非纳米混悬液体外溶出度,UPLC-MS/MS法检测大鼠中他达拉非的血药浓度.结果:他达拉非纳米混悬液最优处方为他达拉非质量分数2％、HPC1％和SDS0.1％;最优工艺为粒径0.1 mm氧化锆珠,转速3 000 r·min-1,研磨时间30 min.制备的他达拉非纳米混悬液PDI为0.173±0.013,Zeta电位为(-22.6±0.4)mV,纳米颗粒为棒状结晶,粒径为(218.2±1.3)nm,分布均匀,晶型稳定;体外溶出度10 min内达到99％,大鼠体内生物利用度为原料药的4.01倍,在室温条件下放置6个月稳定性良好.结论:介质研磨法制备他达拉非纳米混悬液方法简单,产品稳定性好,能显著提高他达拉非溶出度和生物利用度. |
| Keywords | |
| URL | [Source Record] |
| Language | Chinese
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| SUSTech Authorship | Others
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| Data Source | WanFang
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| WanFangID | zgyyyx202211007
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| Citation statistics |
Cited Times [WOS]:0
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| Document Type | Journal Article |
| Identifier | http://kc.sustech.edu.cn/handle/2SGJ60CL/401936 |
| Department | School of Medicine |
| Affiliation | 1.广州中医药大学第一临床医学院,广东广州510006 2.广州中医药大学中药学院,广东广州510006 3.南方科技大学医学院,广东深圳518055 |
| Recommended Citation GB/T 7714 |
戈富城,罗丹冬,章秀冰,等. 介质研磨法制备他达拉非纳米混悬液研究[J]. 中国医院药学杂志,2022,42(11):1121-1125,1137.
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| APA |
戈富城.,罗丹冬.,章秀冰.,黄雅婷.,陈婷婷.,...&丘振文.(2022).介质研磨法制备他达拉非纳米混悬液研究.中国医院药学杂志,42(11),1121-1125,1137.
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| MLA |
戈富城,et al."介质研磨法制备他达拉非纳米混悬液研究".中国医院药学杂志 42.11(2022):1121-1125,1137.
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