中文版 | English
Title

介质研磨法制备他达拉非纳米混悬液研究

Alternative Title
Preparation of tadalafil nanosuspension by wet media milling
Author
Publication Years
2022
DOI
Source Title
ISSN
1001-5213
Volume42Issue:11Pages:1121-1125,1137
Abstract
目的:采用介质研磨法制备他达拉非纳米混悬液,以提高他达拉非的溶出度和生物利用度.方法:以粒径、多分散指数(PDI)、Zeta电位和物理稳定性为评价指标,优化处方和工艺参数;采用扫描电镜(SEM)、X-射线粉末衍射法(XRPD)、差示扫描量热法(DSC)对样品进行表征,HPLC法测定他达拉非纳米混悬液体外溶出度,UPLC-MS/MS法检测大鼠中他达拉非的血药浓度.结果:他达拉非纳米混悬液最优处方为他达拉非质量分数2%、HPC1%和SDS0.1%;最优工艺为粒径0.1 mm氧化锆珠,转速3 000 r·min-1,研磨时间30 min.制备的他达拉非纳米混悬液PDI为0.173±0.013,Zeta电位为(-22.6±0.4)mV,纳米颗粒为棒状结晶,粒径为(218.2±1.3)nm,分布均匀,晶型稳定;体外溶出度10 min内达到99%,大鼠体内生物利用度为原料药的4.01倍,在室温条件下放置6个月稳定性良好.结论:介质研磨法制备他达拉非纳米混悬液方法简单,产品稳定性好,能显著提高他达拉非溶出度和生物利用度.
Keywords
URL[Source Record]
Language
Chinese
SUSTech Authorship
Others
Data Source
WanFang
WanFangID
zgyyyx202211007
Citation statistics
Cited Times [WOS]:0
Document TypeJournal Article
Identifierhttp://kc.sustech.edu.cn/handle/2SGJ60CL/401936
DepartmentSchool of Medicine
Affiliation
1.广州中医药大学第一临床医学院,广东广州510006
2.广州中医药大学中药学院,广东广州510006
3.南方科技大学医学院,广东深圳518055
Recommended Citation
GB/T 7714
戈富城,罗丹冬,章秀冰,等. 介质研磨法制备他达拉非纳米混悬液研究[J]. 中国医院药学杂志,2022,42(11):1121-1125,1137.
APA
戈富城.,罗丹冬.,章秀冰.,黄雅婷.,陈婷婷.,...&丘振文.(2022).介质研磨法制备他达拉非纳米混悬液研究.中国医院药学杂志,42(11),1121-1125,1137.
MLA
戈富城,et al."介质研磨法制备他达拉非纳米混悬液研究".中国医院药学杂志 42.11(2022):1121-1125,1137.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Export to Excel
Export to Csv
Altmetrics Score
Google Scholar
Similar articles in Google Scholar
[戈富城]'s Articles
[罗丹冬]'s Articles
[章秀冰]'s Articles
Baidu Scholar
Similar articles in Baidu Scholar
[戈富城]'s Articles
[罗丹冬]'s Articles
[章秀冰]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[戈富城]'s Articles
[罗丹冬]'s Articles
[章秀冰]'s Articles
Terms of Use
No data!
Social Bookmark/Share
No comment.

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.