中文版 | English
Title

Current understanding of osteoarthritis pathogenesis and relevant new approaches

Author
Corresponding AuthorChen, Di
Publication Years
2022-09-20
DOI
Source Title
ISSN
2095-4700
EISSN
2095-6231
Volume10Issue:1
Abstract

Osteoarthritis (OA) is the most common degenerative joint disease that causes painful swelling and permanent damage to the joints in the body. The molecular mechanisms of OA are currently unknown. OA is a heterogeneous disease that affects the entire joint, and multiple tissues are altered during OA development. To better understand the pathological mechanisms of OA, new approaches, methods, and techniques need to be used to understand OA pathogenesis. In this review, we first focus on the epigenetic regulation of OA, with a particular focus on DNA methylation, histone modification, and microRNA regulation, followed by a summary of several key mediators in OA-associated pain. We then introduce several innovative techniques that have been and will continue to be used in the fields of OA and OA-associated pain, such as CRISPR, scRNA sequencing, and lineage tracing. Next, we discuss the timely updates concerning cell death regulation in OA pathology, including pyroptosis, ferroptosis, and autophagy, as well as their individual roles in OA and potential molecular targets in treating OA. Finally, our review highlights new directions on the role of the synovial lymphatic system in OA. An improved understanding of OA pathogenesis will aid in the development of more specific and effective therapeutic interventions for OA.

URL[Source Record]
Indexed By
Language
English
Important Publications
ESI Hot Papers
SUSTech Authorship
Others
Funding Project
National Natural Science Foundation of China (NSFC)[
WOS Research Area
Cell Biology
WOS Subject
Cell & Tissue Engineering
WOS Accession No
WOS:000855783400001
Publisher
Data Source
Web of Science
Citation statistics
Cited Times [WOS]:18
Document TypeJournal Article
Identifierhttp://kc.sustech.edu.cn/handle/2SGJ60CL/402325
DepartmentSchool of Medicine
南方科技大学医学院_生物化学系
Affiliation
1.Chinese Acad Sci, Res Ctr Comp Aided Drug Discovery, Shenzhen Inst Adv Technol, Shenzhen 518005, Peoples R China
2.Chinese Acad Sci, Fac Pharmaceut Sci, Shenzhen Inst Adv Technol, Shenzhen 518055, Peoples R China
3.Washington Univ, Sch Med, Dept Orthoped Surg, St Louis, MO 63110 USA
4.Southern Univ Sci & Technol, Sch Med, Shenzhen 518055, Peoples R China
5.Army Med Univ, Daping Hosp, Dept Wound Repair & Rehabil, State Key Lab Trauma Burns & Combined Injury, Chongqing 400042, Peoples R China
6.Chinese Acad Sci, Res Ctr Human Tissues & Organs Degenerat, Shenzhen Inst Adv Technol, Shenzhen 518055, Peoples R China
7.Univ Rochester, Ctr Musculoskeletal Res, Dept Pathol & Lab Med, Med Ctr, Rochester, NY 14642 USA
Recommended Citation
GB/T 7714
Tong, Liping,Yu, Huan,Huang, Xingyun,et al. Current understanding of osteoarthritis pathogenesis and relevant new approaches[J]. Bone Research,2022,10(1).
APA
Tong, Liping.,Yu, Huan.,Huang, Xingyun.,Shen, Jie.,Xiao, Guozhi.,...&Chen, Di.(2022).Current understanding of osteoarthritis pathogenesis and relevant new approaches.Bone Research,10(1).
MLA
Tong, Liping,et al."Current understanding of osteoarthritis pathogenesis and relevant new approaches".Bone Research 10.1(2022).
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