中文版 | English
Title

Photothermal Nanozymatic Nanoparticles Induce Ferroptosis and Apoptosis through Tumor Microenvironment Manipulation for Cancer Therapy

Author
Corresponding AuthorDong, Shaohong; Geng, Qingshan; Li, Zhijie; Wang, Jigang
Publication Years
2022-09-01
DOI
Source Title
ISSN
1613-6810
EISSN
1613-6829
Abstract
It is highly desirable to design a single modality that can simultaneously trigger apoptosis and ferroptosis to efficiently eliminate tumor progression. Herein, a nanosystem based on the intrinsic properties of tumor microenvironment (TME) is designed to achieve tumor control through the simultaneous induction of ferroptosis and apoptosis. CuCP molecules are encapsulated in a liposome-based nanosystem to assemble into biocompatible and stable CuCP nanoparticles (CuCP Lipo NPs). This nanosystem intrinsically possesses nanozymatic activity and photothermal characteristics due to the property of Cu atoms and the structure of CuCP Lipo NPs. It is demonstrated that the synergistic strategy increases the intracellular lipid-reactive oxides species, induces the occurrence of ferroptosis and apoptosis, and completely eradicates the tumors in vivo. Proteomics analysis further discloses the key involved proteins (including Tp53, HMOX1, Ptgs2, Tfrc, Slc11a2, Mgst2, Sod1, and several GST family members) and pathways (including apoptosis, ferroptosis, and ROS synthesis). Conclusively, this work develops a strategy based on one nanosystem to synergistically induce ferroptosis and apoptosis in vivo for tumor suppression, which holds great potential in the clinical translation for tumor therapy.
Keywords
URL[Source Record]
Indexed By
Language
English
SUSTech Authorship
First ; Corresponding
Funding Project
National Key Research and Development Program of China[2020YFA0908000] ; Innovation Team and Talents Cultivation Program of the National Administration of Traditional Chinese Medicine[ZYYCXTD-C-202002] ; Basic and Applied Basic Research Foundation of Guang Dong Province[2021A1515012164] ; International Science and Technology Cooperation for Shenzhen Technology Innovation Plan[GJHZ20200731095411034] ; CACMS Innovation Fund["CI2021A05101","CI2021A05104"]
WOS Research Area
Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS Subject
Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
WOS Accession No
WOS:000853968300001
Publisher
Data Source
Web of Science
Citation statistics
Cited Times [WOS]:0
Document TypeJournal Article
Identifierhttp://kc.sustech.edu.cn/handle/2SGJ60CL/402330
DepartmentShenzhen People's Hospital
Affiliation
1.Jinan Univ, Southern Univ Sci & Technol, Affiliated Hosp 1, Clin Med Coll 2,Shenzhen Peoples Hosp,Dept Geriat, Shenzhen 518020, Guangdong, Peoples R China
2.Jinan Univ, Integrated Chinese & Western Med Postdoctoral Res, Guangzhou 510632, Peoples R China
3.Wuhan Univ, Zhongnan Hosp, Dept Hepatobiliary & Pancreat Surg, Wuhan 430062, Hubei, Peoples R China
4.Jinan Univ, Southern Univ Sci & Technol, Affiliated Hosp 1, Clin Med Coll 2,Shenzhen Peoples Hosp,Dept Cardio, Shenzhen 518020, Guangdong, Peoples R China
5.Shanxi Datong Univ, Sch Chem & Chem Engn, Xing Yun St, Datong 037009, Shanxi, Peoples R China
6.China Acad Chinese Med Sci, Artemisinin Res Ctr, Beijing 100700, Peoples R China
7.China Acad Chinese Med Sci, Inst Chinese Mat Med, Beijing 100700, Peoples R China
First Author AffilicationShenzhen People's Hospital
Corresponding Author AffilicationShenzhen People's Hospital
First Author's First AffilicationShenzhen People's Hospital
Recommended Citation
GB/T 7714
Yuan, Haitao,Xia, Peng,Sun, Xin,et al. Photothermal Nanozymatic Nanoparticles Induce Ferroptosis and Apoptosis through Tumor Microenvironment Manipulation for Cancer Therapy[J]. Small,2022.
APA
Yuan, Haitao.,Xia, Peng.,Sun, Xin.,Ma, Jingbo.,Xu, Xiaolong.,...&Wang, Jigang.(2022).Photothermal Nanozymatic Nanoparticles Induce Ferroptosis and Apoptosis through Tumor Microenvironment Manipulation for Cancer Therapy.Small.
MLA
Yuan, Haitao,et al."Photothermal Nanozymatic Nanoparticles Induce Ferroptosis and Apoptosis through Tumor Microenvironment Manipulation for Cancer Therapy".Small (2022).
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Export to Excel
Export to Csv
Altmetrics Score
Google Scholar
Similar articles in Google Scholar
[Yuan, Haitao]'s Articles
[Xia, Peng]'s Articles
[Sun, Xin]'s Articles
Baidu Scholar
Similar articles in Baidu Scholar
[Yuan, Haitao]'s Articles
[Xia, Peng]'s Articles
[Sun, Xin]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Yuan, Haitao]'s Articles
[Xia, Peng]'s Articles
[Sun, Xin]'s Articles
Terms of Use
No data!
Social Bookmark/Share
No comment.

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.