Photothermal Nanozymatic Nanoparticles Induce Ferroptosis and Apoptosis through Tumor Microenvironment Manipulation for Cancer Therapy

Yuan, Haitao1,2; Xia, Peng1,3; Sun, Xin4; Ma, Jingbo1; Xu, Xiaolong2; Fu, Chunjin1; Zhou, Hongchao1; Guan, Yudong1; Li, Zhifen5; Zhao, Shanshan1; Wang, Huifang2; Dai, Lingyun1; Xu, Chengchao1; Dong, Shaohong4; Geng, Qingshan1; Li, Zhijie1; Wang, Jigang1,6,7

2022-09-01

10.1002/smll.202202161

Small   Impact Factor & Quartile

1613-6810

1613-6829

It is highly desirable to design a single modality that can simultaneously trigger apoptosis and ferroptosis to efficiently eliminate tumor progression. Herein, a nanosystem based on the intrinsic properties of tumor microenvironment (TME) is designed to achieve tumor control through the simultaneous induction of ferroptosis and apoptosis. CuCP molecules are encapsulated in a liposome-based nanosystem to assemble into biocompatible and stable CuCP nanoparticles (CuCP Lipo NPs). This nanosystem intrinsically possesses nanozymatic activity and photothermal characteristics due to the property of Cu atoms and the structure of CuCP Lipo NPs. It is demonstrated that the synergistic strategy increases the intracellular lipid-reactive oxides species, induces the occurrence of ferroptosis and apoptosis, and completely eradicates the tumors in vivo. Proteomics analysis further discloses the key involved proteins (including Tp53, HMOX1, Ptgs2, Tfrc, Slc11a2, Mgst2, Sod1, and several GST family members) and pathways (including apoptosis, ferroptosis, and ROS synthesis). Conclusively, this work develops a strategy based on one nanosystem to synergistically induce ferroptosis and apoptosis in vivo for tumor suppression, which holds great potential in the clinical translation for tumor therapy.

catalytic therapy ferroptosis nanozymes photothermal therapy

SCI

English

First ; Corresponding

National Key Research and Development Program of China[2020YFA0908000] ; Innovation Team and Talents Cultivation Program of the National Administration of Traditional Chinese Medicine[ZYYCXTD-C-202002] ; Basic and Applied Basic Research Foundation of Guang Dong Province[2021A1515012164] ; International Science and Technology Cooperation for Shenzhen Technology Innovation Plan[GJHZ20200731095411034] ; CACMS Innovation Fund["CI2021A05101","CI2021A05104"]

Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics

Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter

WOS:000853968300001

WILEY-V C H VERLAG GMBH

Web of Science

1.Jinan Univ, Southern Univ Sci & Technol, Affiliated Hosp 1, Clin Med Coll 2,Shenzhen Peoples Hosp,Dept Geriat, Shenzhen 518020, Guangdong, Peoples R China
2.Jinan Univ, Integrated Chinese & Western Med Postdoctoral Res, Guangzhou 510632, Peoples R China
3.Wuhan Univ, Zhongnan Hosp, Dept Hepatobiliary & Pancreat Surg, Wuhan 430062, Hubei, Peoples R China
4.Jinan Univ, Southern Univ Sci & Technol, Affiliated Hosp 1, Clin Med Coll 2,Shenzhen Peoples Hosp,Dept Cardio, Shenzhen 518020, Guangdong, Peoples R China
5.Shanxi Datong Univ, Sch Chem & Chem Engn, Xing Yun St, Datong 037009, Shanxi, Peoples R China
6.China Acad Chinese Med Sci, Artemisinin Res Ctr, Beijing 100700, Peoples R China
7.China Acad Chinese Med Sci, Inst Chinese Mat Med, Beijing 100700, Peoples R China

Yuan, Haitao,Xia, Peng,Sun, Xin,et al. Photothermal Nanozymatic Nanoparticles Induce Ferroptosis and Apoptosis through Tumor Microenvironment Manipulation for Cancer Therapy[J]. Small,2022.

Yuan, Haitao.,Xia, Peng.,Sun, Xin.,Ma, Jingbo.,Xu, Xiaolong.,...&Wang, Jigang.(2022).Photothermal Nanozymatic Nanoparticles Induce Ferroptosis and Apoptosis through Tumor Microenvironment Manipulation for Cancer Therapy.Small.

Yuan, Haitao,et al."Photothermal Nanozymatic Nanoparticles Induce Ferroptosis and Apoptosis through Tumor Microenvironment Manipulation for Cancer Therapy".Small (2022).