Title | Access to dialkylated allylic stereogenic centers by Ni-catalysed enantioselective hydrovinylation of unactivated alkenes |
Author | |
Corresponding Author | Shu, Wei |
Joint first author | Zhang, Jian-Xin; Yang, Peng-Fei |
Publication Years | 2022-09-01
|
DOI | |
Source Title | |
ISSN | 2041-6520
|
EISSN | 2041-6539
|
Abstract | Tertiary dialkylated allylic stereogenic centers are widespread substructures in bioactive molecules and natural products. However, enantioselective access to dialkyl substituted allylic motifs remains a long-term challenge. Herein, a straightforward protocol to build allylic dialkylated stereogenic centers enabled by nickel-catalysed regio- and enantioselective hydrovinylation of isolated unactivated alkenes facilitated by a weakly coordinating group with vinyl bromides was developed, affording dialkylated allylic species in good yields with excellent enantioselectivities. The reaction distinguishes distinct alkenes and works for both terminal and internal aliphatic alkenes. The reaction proceeds under mild conditions and tolerates a wide range of functional groups. |
URL | [Source Record] |
Indexed By | |
Language | English
|
Important Publications | NI Journal Papers
|
SUSTech Authorship | First
; 共同第一
; Corresponding
|
Funding Project | NSFC[
|
WOS Research Area | Chemistry
|
WOS Subject | Chemistry, Multidisciplinary
|
WOS Accession No | WOS:000855774600001
|
Publisher | |
Data Source | Web of Science
|
Publication Status | 正式出版
|
Citation statistics |
Cited Times [WOS]:1
|
Document Type | Journal Article |
Identifier | http://kc.sustech.edu.cn/handle/2SGJ60CL/402334 |
Department | Department of Chemistry 深圳格拉布斯研究院 |
Affiliation | Southern Univ Sci & Technol, Shenzhen Grubbs Inst, Dept Chem, Guangdong Prov Key Lab Catalysis, Shenzhen 518055, Guangdong, Peoples R China |
First Author Affilication | Department of Chemistry; Shenzhen Grubbs Institute |
Corresponding Author Affilication | Department of Chemistry; Shenzhen Grubbs Institute |
First Author's First Affilication | Department of Chemistry; Shenzhen Grubbs Institute |
Recommended Citation GB/T 7714 |
Zhang, Jian-Xin,Yang, Peng-Fei,Shu, Wei. Access to dialkylated allylic stereogenic centers by Ni-catalysed enantioselective hydrovinylation of unactivated alkenes[J]. Chemical Science,2022.
|
APA |
Zhang, Jian-Xin,Yang, Peng-Fei,&Shu, Wei.(2022).Access to dialkylated allylic stereogenic centers by Ni-catalysed enantioselective hydrovinylation of unactivated alkenes.Chemical Science.
|
MLA |
Zhang, Jian-Xin,et al."Access to dialkylated allylic stereogenic centers by Ni-catalysed enantioselective hydrovinylation of unactivated alkenes".Chemical Science (2022).
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File Name/Size | DocType | Version | Access | License | ||
CS-Zhang jianxin.pdf(997KB) | Restricted Access | -- |
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