中文版 | English
Title

Phosphorylation of Ser82 on IRF3 acts as negative-feedback regulation of IRF3-dependent innate immunity

Author
Corresponding AuthorLiu, Xueyan; Li, Shun
Publication Years
2022-09-01
DOI
Source Title
ISSN
1357-2725
EISSN
1878-5875
Volume150
Abstract
Interferon Regulatory Factor 3 (IRF3) is essential for the production of type I interferon (IFN) during virus infection; however, the mechanism underlying its regulation remains to be elucidated. Here we have identified a novel negative regulatory phosphorylation site on IRF3. In this study, we discovered that Ser82 phosphorylation on IRF3 abrogates virus-induced IFN-8 activation. Furthermore, our results clarified the mechanism in which Ser82 phosphorylation on IRF3 retains the function of dimerization and nuclear import, but abolishes the promoter binding ability of IRF3. In addition, Ser82 phosphorylation on IRF3 serves as a negative feedback mechanism for the type I IFN response. These findings elucidate a previously unknown mechanism for negatively regulating IRF3 to finely tune type I IFN response.
Keywords
URL[Source Record]
Indexed By
Language
English
SUSTech Authorship
Corresponding
Funding Project
Shenzhen Key Laboratory of Prevention and Treatment of Severe Infections[ZDSYS20200811142804014] ; Shenzhen Key Medical Discipline Construction Fund[SZXK045]
WOS Research Area
Biochemistry & Molecular Biology ; Cell Biology
WOS Subject
Biochemistry & Molecular Biology ; Cell Biology
WOS Accession No
WOS:000854908300003
Publisher
Data Source
Web of Science
Citation statistics
Cited Times [WOS]:1
Document TypeJournal Article
Identifierhttp://kc.sustech.edu.cn/handle/2SGJ60CL/402346
DepartmentShenzhen People's Hospital
Affiliation
1.Wuhan Univ Technol, Coll Life Sci, Wuhan, Hubei, Peoples R China
2.Jinan Univ, Dept Crit Care Med, Shenzhen Peoples Hosp, Affiliated Hosp 1,Southern Univ Sci & Technol,Clin, Shenzhen, Peoples R China
3.Sun Yat sen Univ, Affiliated Hosp 1, Inst Precis Med, Sch Med, Guangzhou, Guangdong, Peoples R China
4.Chinese Acad Sci, CAS Key Lab Quantitat Engn Biol, Shenzhen Inst Synthet Biol, Shenzhen Inst Adv Technol, Shenzhen 518055, Peoples R China
Corresponding Author AffilicationShenzhen People's Hospital
Recommended Citation
GB/T 7714
Cheng, Qi,Yuan, Lijia,Guo, Junhui,et al. Phosphorylation of Ser82 on IRF3 acts as negative-feedback regulation of IRF3-dependent innate immunity[J]. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY,2022,150.
APA
Cheng, Qi,Yuan, Lijia,Guo, Junhui,Guo, Deyin,Liu, Xueyan,&Li, Shun.(2022).Phosphorylation of Ser82 on IRF3 acts as negative-feedback regulation of IRF3-dependent innate immunity.INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY,150.
MLA
Cheng, Qi,et al."Phosphorylation of Ser82 on IRF3 acts as negative-feedback regulation of IRF3-dependent innate immunity".INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY 150(2022).
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