中文版 | English
Title

Nonviral Delivery of CRISPR/Cas Systems in mRNA Format

Author
Corresponding AuthorLi, Bin
Publication Years
2022-09-01
DOI
Source Title
ISSN
2699-9307
Abstract
The clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated (Cas) genome editing system provides a powerful toolbox for genetic engineering. However, safe and efficient in vivo delivery of all CRISPR components into the nuclei of target organs remains challenging toward CRISPR/Cas clinical translation. With the rapid development of nanotechnology, the nonviral CRISPR/Cas mRNA delivery systems are emerging as one of the most clinically advanced platforms. CRISPR/Cas mRNA formulated in lipid nanoparticles is currently under clinical trials for treating hereditary transthyretin amyloidosis. Nonviral delivery of CRISPR/Cas systems in mRNA format not only minimizes immunogenicity and carcinogenicity, but also enables transient genome editing, thereby reducing potential off-target effects. The recent advances in the nonviral CRISPR/Cas mRNA delivery systems should facilitate CRISPR technologies toward clinical applications.
Keywords
URL[Source Record]
Indexed By
Language
English
SUSTech Authorship
First ; Corresponding
Funding Project
National Natural Science Foundation of China[82072053] ; Shenzhen Science and Technology Program[RCYX20200714114539061] ; Shenzhen Fundamental Research Foundation[JCYJ20190806150018265]
WOS Research Area
Engineering ; Science & Technology - Other Topics ; Materials Science
WOS Subject
Engineering, Biomedical ; Nanoscience & Nanotechnology ; Materials Science, Biomaterials
WOS Accession No
WOS:000853917400001
Publisher
Data Source
Web of Science
Citation statistics
Cited Times [WOS]:3
Document TypeJournal Article
Identifierhttp://kc.sustech.edu.cn/handle/2SGJ60CL/402361
DepartmentShenzhen People's Hospital
南方科技大学医学院
Affiliation
1.Jinan Univ, Dept Infect Dis, Shenzhen Peoples Hosp, Affiliated Hosp 1,Southern Univ Sci & Technol, Shenzhen 518020, Peoples R China
2.Southern Univ Sci & Technol, Sch Med, Shenzhen 518055, Peoples R China
First Author AffilicationShenzhen People's Hospital
Corresponding Author AffilicationShenzhen People's Hospital;  School of Medicine
First Author's First AffilicationShenzhen People's Hospital
Recommended Citation
GB/T 7714
Liu, Zhen,Li, Zhenghua,Li, Bin. Nonviral Delivery of CRISPR/Cas Systems in mRNA Format[J]. ADVANCED NANOBIOMED RESEARCH,2022.
APA
Liu, Zhen,Li, Zhenghua,&Li, Bin.(2022).Nonviral Delivery of CRISPR/Cas Systems in mRNA Format.ADVANCED NANOBIOMED RESEARCH.
MLA
Liu, Zhen,et al."Nonviral Delivery of CRISPR/Cas Systems in mRNA Format".ADVANCED NANOBIOMED RESEARCH (2022).
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