| Title | Nonviral Delivery of CRISPR/Cas Systems in mRNA Format |
| Author | |
| Corresponding Author | Li, Bin |
| Publication Years | 2022-09-01
|
| DOI | |
| Source Title | |
| ISSN | 2699-9307
|
| Abstract | The clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated (Cas) genome editing system provides a powerful toolbox for genetic engineering. However, safe and efficient in vivo delivery of all CRISPR components into the nuclei of target organs remains challenging toward CRISPR/Cas clinical translation. With the rapid development of nanotechnology, the nonviral CRISPR/Cas mRNA delivery systems are emerging as one of the most clinically advanced platforms. CRISPR/Cas mRNA formulated in lipid nanoparticles is currently under clinical trials for treating hereditary transthyretin amyloidosis. Nonviral delivery of CRISPR/Cas systems in mRNA format not only minimizes immunogenicity and carcinogenicity, but also enables transient genome editing, thereby reducing potential off-target effects. The recent advances in the nonviral CRISPR/Cas mRNA delivery systems should facilitate CRISPR technologies toward clinical applications. |
| Keywords | |
| URL | [Source Record] |
| Indexed By | |
| Language | English
|
| SUSTech Authorship | First
; Corresponding
|
| Funding Project | National Natural Science Foundation of China[82072053]
; Shenzhen Science and Technology Program[RCYX20200714114539061]
; Shenzhen Fundamental Research Foundation[JCYJ20190806150018265]
|
| WOS Research Area | Engineering
; Science & Technology - Other Topics
; Materials Science
|
| WOS Subject | Engineering, Biomedical
; Nanoscience & Nanotechnology
; Materials Science, Biomaterials
|
| WOS Accession No | WOS:000853917400001
|
| Publisher | |
| Data Source | Web of Science
|
| Citation statistics |
Cited Times [WOS]:5
|
| Document Type | Journal Article |
| Identifier | http://kc.sustech.edu.cn/handle/2SGJ60CL/402361 |
| Department | Shenzhen People's Hospital 南方科技大学医学院 |
| Affiliation | 1.Jinan Univ, Dept Infect Dis, Shenzhen Peoples Hosp, Affiliated Hosp 1,Southern Univ Sci & Technol, Shenzhen 518020, Peoples R China 2.Southern Univ Sci & Technol, Sch Med, Shenzhen 518055, Peoples R China |
| First Author Affilication | Shenzhen People's Hospital |
| Corresponding Author Affilication | Shenzhen People's Hospital; School of Medicine |
| First Author's First Affilication | Shenzhen People's Hospital |
| Recommended Citation GB/T 7714 |
Liu, Zhen,Li, Zhenghua,Li, Bin. Nonviral Delivery of CRISPR/Cas Systems in mRNA Format[J]. ADVANCED NANOBIOMED RESEARCH,2022.
|
| APA |
Liu, Zhen,Li, Zhenghua,&Li, Bin.(2022).Nonviral Delivery of CRISPR/Cas Systems in mRNA Format.ADVANCED NANOBIOMED RESEARCH.
|
| MLA |
Liu, Zhen,et al."Nonviral Delivery of CRISPR/Cas Systems in mRNA Format".ADVANCED NANOBIOMED RESEARCH (2022).
|
| Files in This Item: | There are no files associated with this item. | |||||
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