Title | Berberine attenuates diabetic atherosclerosis via enhancing the interplay between KLF16 and PPARa in ApoE(-/-) mice |
Author | |
Corresponding Author | Yang, Shu; Ma, Chuanrui |
Publication Years | 2022-10-08
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DOI | |
Source Title | |
ISSN | 0006-291X
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EISSN | 1090-2104
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Volume | 624 |
Abstract | Cardiovascular disease caused by atherosclerosis is a leading cause of morbidity and mortality worldwide. Diabetes is a major independent risk factor for the development of atherosclerotic cardiovascular diseases. Diabetic atherosclerosis is characterized by hyperglycemia, hyperinsulinemia, and dyslipidemia. These multiple pathological factors can induce oxidative stress, inflammation, and vascular dysfunction, which can initiate and accelerate atherogenesis. Therefore, the strategy to control the development of diabetic atherosclerosis is beneficial to the patients. Berberine is one of the most promising natural products that feature significant beneficial properties on lipid and glucose metabolism, indicating the potential to improve diabetic atherosclerosis. However, the effect and underlying mechanism against diabetic atherosclerosis remain unclear. In this study, HFD and STZ were used to induce diabetic atherosclerosis in apoE(-/-) mice, which was followed by berberine administration. Subsequently, the degree of atherosclerotic plaque, plaque stability, and lipid and glucose metabolism were determined. In addition, the underlying mechanism was revealed by in vitro and in vivo experiments. We observed that berberine improved the dysfunction of lipid and glucose metabolism, and inhibited vascular inflammation, which reduced atherogenesis and plaque vulnerability. Mechanistically, berberine stimulated KLF16 and PPARa expression in vivo and in vitro, and activation of PPARa by berberine was through enhancing KLF16 expression and nuclear translocation. Collectively, berberine can attenuate diabetic atherosclerosis via enhancing the interplay between KLF16 and PPARa, suggesting that KLF16 is a new target of berberine and enhancing KLF16 by berberine is an efficient strategy for alleviating diabetic atherosclerosis. (C) 2022 Elsevier Inc. All rights reserved. |
Keywords | |
URL | [Source Record] |
Indexed By | |
Language | English
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SUSTech Authorship | Corresponding
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Funding Project | research project of the Tianjin education commission[2019KJ044]
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WOS Research Area | Biochemistry & Molecular Biology
; Biophysics
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WOS Subject | Biochemistry & Molecular Biology
; Biophysics
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WOS Accession No | WOS:000852817200010
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Publisher | |
ESI Research Field | BIOLOGY & BIOCHEMISTRY
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Data Source | Web of Science
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Citation statistics |
Cited Times [WOS]:3
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Document Type | Journal Article |
Identifier | http://kc.sustech.edu.cn/handle/2SGJ60CL/402372 |
Department | Shenzhen People's Hospital |
Affiliation | 1.Tianjin Univ Tradit Chinese Med, Teaching Hosp 1, Tianjin, Peoples R China 2.Natl Clin Res Ctr Chinese Med Acupuncture & Moxib, Taipei, Taiwan 3.Southern Univ Sci & Technol, Shenzhen Peoples Hosp, Jinan Univ, Affiliated Hosp 1,Dept Geriatr,Clin Med Coll 2, Shenzhen 518020, Guangdong, Peoples R China 4.Guangdong Med Univ, Affiliated Hosp, Guangzhou, Guangdong, Peoples R China |
Corresponding Author Affilication | Shenzhen People's Hospital |
Recommended Citation GB/T 7714 |
Man, Bin,Hu, Cuilin,Yang, Guangyan,et al. Berberine attenuates diabetic atherosclerosis via enhancing the interplay between KLF16 and PPARa in ApoE(-/-) mice[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2022,624.
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APA |
Man, Bin,Hu, Cuilin,Yang, Guangyan,Xiang, Jiaqing,Yang, Shu,&Ma, Chuanrui.(2022).Berberine attenuates diabetic atherosclerosis via enhancing the interplay between KLF16 and PPARa in ApoE(-/-) mice.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,624.
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MLA |
Man, Bin,et al."Berberine attenuates diabetic atherosclerosis via enhancing the interplay between KLF16 and PPARa in ApoE(-/-) mice".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 624(2022).
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