中文版 | English
Title

Berberine attenuates diabetic atherosclerosis via enhancing the interplay between KLF16 and PPARa in ApoE(-/-) mice

Author
Corresponding AuthorYang, Shu; Ma, Chuanrui
Publication Years
2022-10-08
DOI
Source Title
ISSN
0006-291X
EISSN
1090-2104
Volume624
Abstract
Cardiovascular disease caused by atherosclerosis is a leading cause of morbidity and mortality worldwide. Diabetes is a major independent risk factor for the development of atherosclerotic cardiovascular diseases. Diabetic atherosclerosis is characterized by hyperglycemia, hyperinsulinemia, and dyslipidemia. These multiple pathological factors can induce oxidative stress, inflammation, and vascular dysfunction, which can initiate and accelerate atherogenesis. Therefore, the strategy to control the development of diabetic atherosclerosis is beneficial to the patients. Berberine is one of the most promising natural products that feature significant beneficial properties on lipid and glucose metabolism, indicating the potential to improve diabetic atherosclerosis. However, the effect and underlying mechanism against diabetic atherosclerosis remain unclear. In this study, HFD and STZ were used to induce diabetic atherosclerosis in apoE(-/-) mice, which was followed by berberine administration. Subsequently, the degree of atherosclerotic plaque, plaque stability, and lipid and glucose metabolism were determined. In addition, the underlying mechanism was revealed by in vitro and in vivo experiments. We observed that berberine improved the dysfunction of lipid and glucose metabolism, and inhibited vascular inflammation, which reduced atherogenesis and plaque vulnerability. Mechanistically, berberine stimulated KLF16 and PPARa expression in vivo and in vitro, and activation of PPARa by berberine was through enhancing KLF16 expression and nuclear translocation. Collectively, berberine can attenuate diabetic atherosclerosis via enhancing the interplay between KLF16 and PPARa, suggesting that KLF16 is a new target of berberine and enhancing KLF16 by berberine is an efficient strategy for alleviating diabetic atherosclerosis. (C) 2022 Elsevier Inc. All rights reserved.
Keywords
URL[Source Record]
Indexed By
Language
English
SUSTech Authorship
Corresponding
Funding Project
research project of the Tianjin education commission[2019KJ044]
WOS Research Area
Biochemistry & Molecular Biology ; Biophysics
WOS Subject
Biochemistry & Molecular Biology ; Biophysics
WOS Accession No
WOS:000852817200010
Publisher
ESI Research Field
BIOLOGY & BIOCHEMISTRY
Data Source
Web of Science
Citation statistics
Cited Times [WOS]:4
Document TypeJournal Article
Identifierhttp://kc.sustech.edu.cn/handle/2SGJ60CL/402372
DepartmentShenzhen People's Hospital
Affiliation
1.Tianjin Univ Tradit Chinese Med, Teaching Hosp 1, Tianjin, Peoples R China
2.Natl Clin Res Ctr Chinese Med Acupuncture & Moxib, Taipei, Taiwan
3.Southern Univ Sci & Technol, Shenzhen Peoples Hosp, Jinan Univ, Affiliated Hosp 1,Dept Geriatr,Clin Med Coll 2, Shenzhen 518020, Guangdong, Peoples R China
4.Guangdong Med Univ, Affiliated Hosp, Guangzhou, Guangdong, Peoples R China
Corresponding Author AffilicationShenzhen People's Hospital
Recommended Citation
GB/T 7714
Man, Bin,Hu, Cuilin,Yang, Guangyan,et al. Berberine attenuates diabetic atherosclerosis via enhancing the interplay between KLF16 and PPARa in ApoE(-/-) mice[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2022,624.
APA
Man, Bin,Hu, Cuilin,Yang, Guangyan,Xiang, Jiaqing,Yang, Shu,&Ma, Chuanrui.(2022).Berberine attenuates diabetic atherosclerosis via enhancing the interplay between KLF16 and PPARa in ApoE(-/-) mice.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,624.
MLA
Man, Bin,et al."Berberine attenuates diabetic atherosclerosis via enhancing the interplay between KLF16 and PPARa in ApoE(-/-) mice".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 624(2022).
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