中文版 | English
Title

Ligand Development for Copper-Catalyzed Enantioconvergent Radical Cross-Coupling of Racemic Alkyl Halides

Author
Corresponding AuthorLiu, Xin-Yuan
Publication Years
2022-09-28
DOI
Source Title
ISSN
0002-7863
EISSN
1520-5126
Volume144Issue:38Pages:17319-17329
Abstract

The enantioconvergent cross-coupling of racemic alkyl halides represents a powerful tool for the synthesis of enantioenriched molecules. In this regard, the first-row transition metal catalysis provides a suitable mechanism for stereoconvergence by converting racemic alkyl halides to prochiral radical intermediates owing to their good single-electron transfer ability. In contrast to the noble development of chiral nickel catalyst, copper-catalyzed enantioconvergent radical cross-coupling of alkyl halides is less studied. Besides the enantiocontrol issue, the major challenge arises from the weak reducing capability of copper that slows the reaction initiation. Recently, significant efforts have been dedicated to basic research aimed at developing chiral ligands for copper-catalyzed enantioconvergent radical cross-coupling of racemic alkyl halides. This perspective will discuss the advances in this burgeoning area with particular emphasis on the strategic chiral anionic ligand design to tune the reducing capability of copper for the reaction initiation under thermal conditions from our research group.

URL[Source Record]
Indexed By
SCI ; EI
Language
English
Important Publications
NI Journal Papers
SUSTech Authorship
First ; Corresponding
Funding Project
National Key R&D Program of China[
WOS Research Area
Chemistry
WOS Subject
Chemistry, Multidisciplinary
WOS Accession No
WOS:000875120200001
Publisher
EI Accession Number
20223812756684
EI Keywords
Catalysis ; Catalysts ; Free Radical Reactions ; Ligands ; Metal Halides ; Stereochemistry ; Synthesis (Chemical)
ESI Classification Code
Copper:544.1 ; Chemistry:801 ; Physical Chemistry:801.4 ; Chemical Reactions:802.2 ; Chemical Agents And Basic Industrial Chemicals:803 ; Chemical Products Generally:804
Scopus EID
2-s2.0-85137933054
Data Source
Scopus
Publication Status
正式出版
Citation statistics
Cited Times [WOS]:26
Document TypeJournal Article
Identifierhttp://kc.sustech.edu.cn/handle/2SGJ60CL/402397
DepartmentDepartment of Chemistry
前沿与交叉科学研究院
深圳格拉布斯研究院
Affiliation
1.Shenzhen Grubbs Institute,Department of Chemistry,Guangdong Provincial Key Laboratory of Catalysis,Southern University of Science and Technology,Shenzhen,518055,China
2.Academy for Advanced Interdisciplinary Studies,Department of Chemistry,Southern University of Science and Technology,Shenzhen,518055,China
First Author AffilicationDepartment of Chemistry;  Shenzhen Grubbs Institute
Corresponding Author AffilicationDepartment of Chemistry;  Shenzhen Grubbs Institute
First Author's First AffilicationDepartment of Chemistry;  Shenzhen Grubbs Institute
Recommended Citation
GB/T 7714
Dong, Xiao-Yang,Li, Zhong-Liang,Gu, Qiang-Shuai,et al. Ligand Development for Copper-Catalyzed Enantioconvergent Radical Cross-Coupling of Racemic Alkyl Halides[J]. Journal of the American Chemical Society,2022,144(38):17319-17329.
APA
Dong, Xiao-Yang,Li, Zhong-Liang,Gu, Qiang-Shuai,&Liu, Xin-Yuan.(2022).Ligand Development for Copper-Catalyzed Enantioconvergent Radical Cross-Coupling of Racemic Alkyl Halides.Journal of the American Chemical Society,144(38),17319-17329.
MLA
Dong, Xiao-Yang,et al."Ligand Development for Copper-Catalyzed Enantioconvergent Radical Cross-Coupling of Racemic Alkyl Halides".Journal of the American Chemical Society 144.38(2022):17319-17329.
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