Title | Ligand Development for Copper-Catalyzed Enantioconvergent Radical Cross-Coupling of Racemic Alkyl Halides |
Author | |
Corresponding Author | Liu, Xin-Yuan |
Publication Years | 2022-09-28
|
DOI | |
Source Title | |
ISSN | 0002-7863
|
EISSN | 1520-5126
|
Volume | 144Issue:38Pages:17319-17329 |
Abstract | The enantioconvergent cross-coupling of racemic alkyl halides represents a powerful tool for the synthesis of enantioenriched molecules. In this regard, the first-row transition metal catalysis provides a suitable mechanism for stereoconvergence by converting racemic alkyl halides to prochiral radical intermediates owing to their good single-electron transfer ability. In contrast to the noble development of chiral nickel catalyst, copper-catalyzed enantioconvergent radical cross-coupling of alkyl halides is less studied. Besides the enantiocontrol issue, the major challenge arises from the weak reducing capability of copper that slows the reaction initiation. Recently, significant efforts have been dedicated to basic research aimed at developing chiral ligands for copper-catalyzed enantioconvergent radical cross-coupling of racemic alkyl halides. This perspective will discuss the advances in this burgeoning area with particular emphasis on the strategic chiral anionic ligand design to tune the reducing capability of copper for the reaction initiation under thermal conditions from our research group. |
URL | [Source Record] |
Indexed By | |
Language | English
|
Important Publications | NI Journal Papers
|
SUSTech Authorship | First
; Corresponding
|
Funding Project | National Key R&D Program of China[
|
WOS Research Area | Chemistry
|
WOS Subject | Chemistry, Multidisciplinary
|
WOS Accession No | WOS:000875120200001
|
Publisher | |
EI Accession Number | 20223812756684
|
EI Keywords | Catalysis
; Catalysts
; Free Radical Reactions
; Ligands
; Metal Halides
; Stereochemistry
; Synthesis (Chemical)
|
ESI Classification Code | Copper:544.1
; Chemistry:801
; Physical Chemistry:801.4
; Chemical Reactions:802.2
; Chemical Agents And Basic Industrial Chemicals:803
; Chemical Products Generally:804
|
Scopus EID | 2-s2.0-85137933054
|
Data Source | Scopus
|
Publication Status | 正式出版
|
Citation statistics |
Cited Times [WOS]:26
|
Document Type | Journal Article |
Identifier | http://kc.sustech.edu.cn/handle/2SGJ60CL/402397 |
Department | Department of Chemistry 前沿与交叉科学研究院 深圳格拉布斯研究院 |
Affiliation | 1.Shenzhen Grubbs Institute,Department of Chemistry,Guangdong Provincial Key Laboratory of Catalysis,Southern University of Science and Technology,Shenzhen,518055,China 2.Academy for Advanced Interdisciplinary Studies,Department of Chemistry,Southern University of Science and Technology,Shenzhen,518055,China |
First Author Affilication | Department of Chemistry; Shenzhen Grubbs Institute |
Corresponding Author Affilication | Department of Chemistry; Shenzhen Grubbs Institute |
First Author's First Affilication | Department of Chemistry; Shenzhen Grubbs Institute |
Recommended Citation GB/T 7714 |
Dong, Xiao-Yang,Li, Zhong-Liang,Gu, Qiang-Shuai,et al. Ligand Development for Copper-Catalyzed Enantioconvergent Radical Cross-Coupling of Racemic Alkyl Halides[J]. Journal of the American Chemical Society,2022,144(38):17319-17329.
|
APA |
Dong, Xiao-Yang,Li, Zhong-Liang,Gu, Qiang-Shuai,&Liu, Xin-Yuan.(2022).Ligand Development for Copper-Catalyzed Enantioconvergent Radical Cross-Coupling of Racemic Alkyl Halides.Journal of the American Chemical Society,144(38),17319-17329.
|
MLA |
Dong, Xiao-Yang,et al."Ligand Development for Copper-Catalyzed Enantioconvergent Radical Cross-Coupling of Racemic Alkyl Halides".Journal of the American Chemical Society 144.38(2022):17319-17329.
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