中文版 | English
Title

Accelerated spread of antibiotic resistance genes (ARGs) induced by non-antibiotic conditions: Roles and mechanisms

Author
Corresponding AuthorNi, Bing Jie
Publication Years
2022-10-01
DOI
Source Title
ISSN
0043-1354
EISSN
1879-2448
Volume224
Abstract

The global spread of antibiotic resistance genes (ARGs) has wreaked havoc with the treatment efficiency of antibiotics and, ultimately, anti-microbial chemotherapy, and has been conventionally attributed to the abuse and misuse of antibiotics. However, the ancient ARGs have alterative functions in bacterial physiology and thus they could be co-regulated by non-antibiotic conditions. Recent research has demonstrated that many non-antibiotic chemicals such as microplastics, metallic nanoparticles and non-antibiotic drugs, as well as some non-antibiotic conditions, can accelerate the dissemination of ARGs. These results suggested that the role of antibiotics might have been previously overestimated whereas the effects of non-antibiotic conditions were possibly ignored. Thus, in an attempt to fully understand the fate and behavior of ARGs in the eco-system, it is urgent to critically highlight the role and mechanisms of non-antibiotic chemicals and related environmental factors in the spread of ARGs. To this end, this timely review assessed the evolution of ARGs, especially its function alteration, summarized the non-antibiotic chemicals promoting the spread of ARGs, evaluated the non-antibiotic conditions related to ARG dissemination and analyzed the molecular mechanisms related to spread of ARGs induced by the non-antibiotic factors. Finally, this review then provided several critical perspectives for future research.

Keywords
URL[Source Record]
Indexed By
Language
English
Important Publications
NI Journal Papers
SUSTech Authorship
Others
Funding Project
Australian Research Council[DE220100530] ; Australian Research Council[DP220101139]
WOS Research Area
Engineering ; Environmental Sciences & Ecology ; Water Resources
WOS Subject
Engineering, Environmental ; Environmental Sciences ; Water Resources
WOS Accession No
WOS:000859403700009
Publisher
ESI Research Field
ENVIRONMENT/ECOLOGY
Scopus EID
2-s2.0-85138830175
Data Source
Scopus
Citation statistics
Cited Times [WOS]:17
Document TypeJournal Article
Identifierhttp://kc.sustech.edu.cn/handle/2SGJ60CL/402667
DepartmentCollege of Engineering
工学院_环境科学与工程学院
Affiliation
1.Centre for Technology in Water and Wastewater,School of Civil and Environmental Engineering,University of Technology Sydney,Sydney,2007,Australia
2.School of Environmental Science and Engineering,College of Engineering,Southern University of Science and Technology,Shenzhen,518055,China
Recommended Citation
GB/T 7714
Shi, Xingdong,Xia, Yu,Wei, Wei,et al. Accelerated spread of antibiotic resistance genes (ARGs) induced by non-antibiotic conditions: Roles and mechanisms[J]. WATER RESEARCH,2022,224.
APA
Shi, Xingdong,Xia, Yu,Wei, Wei,&Ni, Bing Jie.(2022).Accelerated spread of antibiotic resistance genes (ARGs) induced by non-antibiotic conditions: Roles and mechanisms.WATER RESEARCH,224.
MLA
Shi, Xingdong,et al."Accelerated spread of antibiotic resistance genes (ARGs) induced by non-antibiotic conditions: Roles and mechanisms".WATER RESEARCH 224(2022).
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