Case report: Significant relief of linezolid-induced peripheral neuropathy in a pre-XDR-TB case after acupuncture treatment

Mo，Yuping1; Zhu，Zhu2; Tan，Jie3; Liang，Zhilin3; Wu，Jiahui1; Chen，Xingcheng1; Hu，Ming1; Zhang，Peize3; Deng，Guofang3; Fu，Liang3

2022-09-08

10.3389/fneur.2022.985499

Frontiers in Neurology   Impact Factor & Quartile

1664-2295

1664-2295

The revised WHO guidelines on multidrug- or rifampicin-resistant tuberculosis (MDR/RR-TB) include linezolid in the core drug group. Common adverse events of prolonged linezolid use are bone marrow suppression and peripheral neuropathy (PN). Available measures against linezolid-induced PN (LIPN) often have insignificant effects, leading to linezolid discontinuation and a decline in the success rate of MDR/RR-TB treatment. Acupuncture treatment is a symptomatic treatment measure from traditional Chinese medicine (TCM) to relieve pain with overall very low evidence and has never been reported in LIPN. The pilot use of acupuncture in a pre-extensively drug-resistant (XDR)-TB (a more severe form of MDR/RR-TB) patient exhibited significant improvements in LIPN and thus maintained linezolid in the regimen for a longer period.

acupuncture adverse reactions linezolid multidrug-resistant tuberculosis peripheral neuropathy

SCI

English

First ; Corresponding

Neurosciences & Neurology

Clinical Neurology ; Neurosciences

WOS:000859624200001

FRONTIERS MEDIA SA

2-s2.0-85138497892

Scopus

1.Acupuncture and Physiotherapy Department,National Clinical Research Center for Infectious Disease,Shenzhen Third People's Hospital,Southern University of Science and Technology,Shenzhen,China
2.Breax Laboratory,PCAB Research Center of Breath and Metabolism,Beijing,China
3.Pulmonary Diseases Department Two,National Clinical Research Center for Infectious Disease,Shenzhen Third People's Hospital,Southern University of Science and Technology,Shenzhen,China

Mo，Yuping,Zhu，Zhu,Tan，Jie,et al. Case report: Significant relief of linezolid-induced peripheral neuropathy in a pre-XDR-TB case after acupuncture treatment[J]. Frontiers in Neurology,2022,13.

Mo，Yuping.,Zhu，Zhu.,Tan，Jie.,Liang，Zhilin.,Wu，Jiahui.,...&Fu，Liang.(2022).Case report: Significant relief of linezolid-induced peripheral neuropathy in a pre-XDR-TB case after acupuncture treatment.Frontiers in Neurology,13.

Mo，Yuping,et al."Case report: Significant relief of linezolid-induced peripheral neuropathy in a pre-XDR-TB case after acupuncture treatment".Frontiers in Neurology 13(2022).