中文版 | English
Title

The role of tumor-associated macrophages and soluble mediators in pulmonary metastatic melanoma

Author
Corresponding AuthorZhang,Jianglin; Chen,Shanze
Publication Years
2022-09-05
DOI
Source Title
ISSN
1664-3224
EISSN
1664-3224
Volume13
Abstract
Skin malignant melanoma is a highly aggressive skin tumor, which is also a major cause of skin cancer-related mortality. It can spread from a relatively small primary tumor and metastasize to multiple locations, including lymph nodes, lungs, liver, bone, and brain. What’s more metastatic melanoma is the main cause of its high mortality. Among all organs, the lung is one of the most common distant metastatic sites of melanoma, and the mortality rate of melanoma lung metastasis is also very high. Elucidating the mechanisms involved in the pulmonary metastasis of cutaneous melanoma will not only help to provide possible explanations for its etiology and progression but may also help to provide potential new therapeutic targets for its treatment. Increasing evidence suggests that tumor-associated macrophages (TAMs) play an important regulatory role in the migration and metastasis of various malignant tumors. Tumor-targeted therapy, targeting tumor-associated macrophages is thus attracting attention, particularly for advanced tumors and metastatic tumors. However, the relevant role of tumor-associated macrophages in cutaneous melanoma lung metastasis is still unclear. This review will present an overview of the origin, classification, polarization, recruitment, regulation and targeting treatment of tumor-associated macrophages, as well as the soluble mediators involved in these processes and a summary of their possible role in lung metastasis from cutaneous malignant melanoma. This review particularly aims to provide insight into mechanisms and potential therapeutic targets to readers, interested in pulmonary metastasis melanoma.
Keywords
URL[Source Record]
Indexed By
Language
English
SUSTech Authorship
Corresponding
Funding Project
[82073018] ; [82073019] ; [JCYJ20210324114212035]
WOS Research Area
Immunology
WOS Subject
Immunology
WOS Accession No
WOS:000859174200001
Publisher
Scopus EID
2-s2.0-85138266363
Data Source
Scopus
Citation statistics
Cited Times [WOS]:1
Document TypeJournal Article
Identifierhttp://kc.sustech.edu.cn/handle/2SGJ60CL/402705
DepartmentShenzhen People's Hospital
Affiliation
1.The Department of Respiratory Diseases and Critic Care Unit,Shenzhen Institute of Respiratory Disease,Shenzhen Key Laboratory of Respiratory Disease,Shenzhen People’s Hospital (The Second Clinical Medical College),Jinan University,Guangdong,China
2.The First Affiliated Hospital,Southern University of Science and Technology,Shenzhen,China
3.Department of Dermatology,Xiangya Hospital of Central South University,Changsha,China
4.Department of Plastic Surgery,Xiangya Hospital,Central South University,Changsha,China
5.Institute of Lung Health and Immunity (LHI),Comprehensive Pneumology Center (CPC),Helmholtz Munich,German Center for Lung Research (DZL),Munich,Germany
6.Department of Dermatology,Shenzhen People’s Hospital,The Second Clinical Medical College,Jinan University,Guangdong,China
7.Candidate Branch of National Clinical Research Center for Skin Diseases,Shenzhen,China
First Author AffilicationShenzhen People's Hospital
Corresponding Author AffilicationShenzhen People's Hospital
Recommended Citation
GB/T 7714
Xiong,Kaifen,Qi,Min,Stoeger,Tobias,et al. The role of tumor-associated macrophages and soluble mediators in pulmonary metastatic melanoma[J]. Frontiers in Immunology,2022,13.
APA
Xiong,Kaifen,Qi,Min,Stoeger,Tobias,Zhang,Jianglin,&Chen,Shanze.(2022).The role of tumor-associated macrophages and soluble mediators in pulmonary metastatic melanoma.Frontiers in Immunology,13.
MLA
Xiong,Kaifen,et al."The role of tumor-associated macrophages and soluble mediators in pulmonary metastatic melanoma".Frontiers in Immunology 13(2022).
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