Single-cell analysis of the adaptive immune response to SARS-CoV-2 infection and vaccination

Qi，Furong1,2; Cao，Yingyin1; Zhang，Shuye3; Zhang，Zheng1,2,4

2022-09-02

10.3389/fimmu.2022.964976

Frontiers in Immunology   Impact Factor & Quartile

1664-3224

1664-3224

Amid the ongoing Coronavirus Disease 2019 (COVID-19) pandemic, vaccination and early therapeutic interventions are the most effective means to combat and control the severity of the disease. Host immune responses to SARS-CoV-2 and its variants, particularly adaptive immune responses, should be fully understood to develop improved strategies to implement these measures. Single-cell multi-omic technologies, including flow cytometry, single-cell transcriptomics, and single-cell T-cell receptor (TCR) and B-cell receptor (BCR) profiling, offer a better solution to examine the protective or pathological immune responses and molecular mechanisms associated with SARS-CoV-2 infection, thus providing crucial support for the development of vaccines and therapeutics for COVID-19. Recent reviews have revealed the overall immune landscape of natural SARS-CoV-2 infection, and this review will focus on adaptive immune responses (including T cells and B cells) to SARS-CoV-2 revealed by single-cell multi-omics technologies. In addition, we explore how the single-cell analyses disclose the critical components of immune protection and pathogenesis during SARS-CoV-2 infection through the comparison between the adaptive immune responses induced by natural infection and by vaccination.

adaptive immune response antibody production infection SARS-CoV-2 vaccine

SCI

English

First ; Corresponding

National Science Fund for Distinguished Young Scholars[82025022] ; Shenzhen Science and Technology Program[ZDSYS20210623091810030] ; Shenzhen Bay Funding["2020B1111340074","2020B1111340075"] ; Central Charity Fund of Chinese Academy of Medical Science[2020-PT310-009]

Immunology

Immunology

WOS:000883617600001

FRONTIERS MEDIA SA

2-s2.0-85138204549

Scopus

1.Institute for Hepatology,National Clinical Research Center for Infectious Disease,Shenzhen Third People’s Hospital,The Second Affiliated Hospital,School of Medicine,Southern University of Science and Technology,Shenzhen,China
2.Shenzhen Key Laboratory of Single-Cell Omics Reasearch and Application,Shenzhen,China
3.Clinical Center for BioTherapy and Institutes of Biomedical Sciences,Zhongshan Hospital,Fudan University,Shanghai,China
4.Shenzhen Research Center for Communicable Disease Diagnosis and Treatment of Chinese Academy of Medical Science,Shenzhen,China

Qi，Furong,Cao，Yingyin,Zhang，Shuye,et al. Single-cell analysis of the adaptive immune response to SARS-CoV-2 infection and vaccination[J]. Frontiers in Immunology,2022,13.

Qi，Furong,Cao，Yingyin,Zhang，Shuye,&Zhang，Zheng.(2022).Single-cell analysis of the adaptive immune response to SARS-CoV-2 infection and vaccination.Frontiers in Immunology,13.

Qi，Furong,et al."Single-cell analysis of the adaptive immune response to SARS-CoV-2 infection and vaccination".Frontiers in Immunology 13(2022).