Association of Lifestyle With Incidence of Heart Failure According to Metabolic and Genetic Risk Status: A Population-Based Prospective Study

Zhu，Zhengbao1; Li，Fu Rong2,3,4; Jia，Yiming1; Li，Yang5; Guo，Daoxia1,6; Chen，Jingsi7; Tian，Haili8; Yang，Jing7,9; Yang，Huan Huan10; Chen，Li Hua11; Zhang，Kaixin1; Yang，Pinni1; Sun，Lulu1; Shi，Mengyao1; Zhang，Yonghong1; Qin，Li Qiang7; Chen，Guo Chong7

2022-09-01

10.1161/CIRCHEARTFAILURE.122.009592

Circulation. Heart failure   Impact Factor & Quartile

1941-3289

1941-3297

BACKGROUND: Whether lifestyle factors are similarly associated with risk of heart failure (HF) for individuals with different metabolic or genetic risk status remains unclear. METHODS: We included 464 483 participants from UK Biobank who were free of major cardiovascular disease or HF during baseline recruitment. Healthy lifestyle factors included avoidance of smoking, no obesity, regular physical activity, and healthy diet. Lifestyle was categorized as favorable (3 or 4 healthy lifestyle factors), intermediate (2 healthy lifestyle factors), and unfavorable (0 or 1 healthy lifestyle factor) lifestyles. Metabolic status was defined by the presence of hypertension, high total cholesterol, or diabetes at baseline. A weighted genetic risk score was created based on 12 single-nucleotide polymorphisms associated with HF. RESULTS: Compared with favorable lifestyle, the multivariable-adjusted hazard ratios of HF were 1.79 (95% CI, 1.68-1.90) and 2.90 (95% CI, 2.70-3.11) for intermediate lifestyle and unfavorable lifestyle, respectively (Ptrend <0.0001). This association was largely consistent regardless of the presence of any single metabolic risk factor or the number of metabolic risk factors (Pinteraction ≥0.21). The association was also similar across different genetic risk categories (Pinteraction=0.92). In a joint analysis, the hazard ratio of HF was 4.05 (95% CI, 3.43-4.77) comparing participants who had both higher genetic risk and an unfavorable lifestyle with those having lower genetic risk and a favorable lifestyle. CONCLUSIONS: Combined lifestyle was associated with incident HF regardless of metabolic or genetic risk status, supporting the recommendation of healthy lifestyles for HF prevention across the entire population.

cardiovascular diseases healthy lifestyle heart failure prospective studies

SCI

English

Others

National Natural Science Foundation of China[82103917] ; Natural Science Research Project of Jiangsu Provincial[21KJB330006]

Cardiovascular System & Cardiology

Cardiac & Cardiovascular Systems

WOS:000917783500001

LIPPINCOTT WILLIAMS & WILKINS

2-s2.0-85138460697

Scopus

1.Department of Epidemiology (Z.Z.,K.Z.,L.S.,Suzhou Medical College of Soochow University,P.Y,China
2.Shenzhen Key Laboratory of Cardiovascular Health and Precision Medicine (F.-R.L.),Southern University of Science and Technology,China
3.School of Public Health and Emergency Management (F.-R.L.),Southern University of Science and Technology,China
4.Department of Epidemiology,School of Public Health,Southern Medical University,China (F.-R.L.),Guangzhou,China
5.Department of Epidemiology and Population Health,Albert Einstein College of Medicine,Bronx,United States
6.School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases and School of Nursing (D.G.),Suzhou Medical College of Soochow University,China
7.Department of Nutrition and Food Hygiene (J.C.,Suzhou Medical College of Soochow University,China
8.School of Kinesiology,Shanghai University of Sport,China (H.T.),China
9.Department of Clinical Nutrition,First Affiliated Hospital of Soochow University,China (J.Y.),Suzhou,China
10.Vanke School of Public Health,Tsinghua University,China (H.-H.Y.),China
11.Department of Nutrition and Food Hygiene,School of Public Health,Nantong University,China (L.-H.C.),China

Zhu，Zhengbao,Li，Fu Rong,Jia，Yiming,et al. Association of Lifestyle With Incidence of Heart Failure According to Metabolic and Genetic Risk Status: A Population-Based Prospective Study[J]. Circulation. Heart failure,2022,15(9).

Zhu，Zhengbao.,Li，Fu Rong.,Jia，Yiming.,Li，Yang.,Guo，Daoxia.,...&Chen，Guo Chong.(2022).Association of Lifestyle With Incidence of Heart Failure According to Metabolic and Genetic Risk Status: A Population-Based Prospective Study.Circulation. Heart failure,15(9).

Zhu，Zhengbao,et al."Association of Lifestyle With Incidence of Heart Failure According to Metabolic and Genetic Risk Status: A Population-Based Prospective Study".Circulation. Heart failure 15.9(2022).