中文版 | English
Title

Outcomes after lung transplantation among Chinese patients with connective tissue disease-associated interstitial lung disease and pulmonary hypertension: a retrospective cohort study

Author
Publication Years
2022-09-01
DOI
Source Title
ISSN
0392-856X
Volume40Issue:9Pages:1666-1673
Abstract
OBJECTIVES: The present study aimed to compare the post-lung transplant survival and complications of connective tissue disease (CTD)-related interstitial lung disease (ILD) and/or pulmonary arterial hypertension with idiopathic pulmonary fibrosis (IPF). METHODS: The clinical data of patients with CTD-ILD or IPF who received lung transplantation between 2015 and 2020 were retrospectively reviewed. Cumulative survival rates after transplantation were estimated using the Kaplan-Meier method. RESULTS: The study included 31 patients with confirmed CTD-ILD and 98 with IPF. Patients with CTD-ILD were significantly younger (53.2 ± 13.7 vs. 62.3 ± 7.2 years, p=0.001) and more likely female (61.3% vs. 7.1%, p<0.001) than patients with IPF. No significant difference was noticed in the 1-year and 5-year survival rates between CTD-ILD and IPF patients (1-year, 73.2% vs 71.4%, p=0.76; 5-year, 69.1% vs. 39.5%, p=0.21). The incidence of primary graft dysfunction was significantly higher in CTD-ILD patients (90.3% vs. 70.4%, p=0.03), while there was no significant difference in primary graft dysfunction-related mortality (6.5% vs. 6.1%, p=0.95) between the two groups. CONCLUSIONS: There was no significant difference in post-lung transplant survival and complications between CTD-ILD and IPF.
URL[Source Record]
Language
English
SUSTech Authorship
Others
ESI Research Field
CLINICAL MEDICINE
Scopus EID
2-s2.0-85138457662
Data Source
Scopus
Citation statistics
Cited Times [WOS]:0
Document TypeJournal Article
Identifierhttp://kc.sustech.edu.cn/handle/2SGJ60CL/402723
DepartmentShenzhen People's Hospital
Affiliation
1.First Affiliated Hospital of Guangzhou Medical University,State Key Laboratory of Respiratory Disease,National Clinical Research Center for Respiratory Disease,Guangzhou Institute of Respiratory Health,Guangzhou,China
2.Southern University of Science and Technology,Second Clinical Medical College of Jinan University,Shenzhen People's Hospital,Shenzhen Institute of Respiratory Diseases,Shenzhen,China
3.First Affiliated Hospital of Guangzhou Medical University,State Key Laboratory of Respiratory Disease,National Clinical Research Center for Respiratory Disease,Guangzhou Institute of Respiratory Health,Guangzhou,China
Recommended Citation
GB/T 7714
Ju,Chunrong,Lian,Qiaoyan,Chen,Ao,et al. Outcomes after lung transplantation among Chinese patients with connective tissue disease-associated interstitial lung disease and pulmonary hypertension: a retrospective cohort study[J]. CLINICAL AND EXPERIMENTAL RHEUMATOLOGY,2022,40(9):1666-1673.
APA
Ju,Chunrong.,Lian,Qiaoyan.,Chen,Ao.,Xu,Xin.,Zhang,Jianheng.,...&He,Jianxing.(2022).Outcomes after lung transplantation among Chinese patients with connective tissue disease-associated interstitial lung disease and pulmonary hypertension: a retrospective cohort study.CLINICAL AND EXPERIMENTAL RHEUMATOLOGY,40(9),1666-1673.
MLA
Ju,Chunrong,et al."Outcomes after lung transplantation among Chinese patients with connective tissue disease-associated interstitial lung disease and pulmonary hypertension: a retrospective cohort study".CLINICAL AND EXPERIMENTAL RHEUMATOLOGY 40.9(2022):1666-1673.
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